Results 1 to 10 of about 176,855 (199)
Hermaphroditism in a Sprague-Dawley Rat [PDF]
Veterinary Pathology, 2007 A spontaneous case of unilateral true hermaphroditism was observed during the routine necropsy of a 9–week-old presumed female Sprague-Dawley rat on a repeat-dose toxicity study. There were no drug-related effects observed. True hermaphroditism is rare in rats, and despite the large numbers of rats examined annually, few cases are reported in the ...
R. W. Diters +4 more
openaire +3 more sources
Urolithiasis in the Sprague-Dawley rat [PDF]
Laboratory Animals, 1979 A 7 year collection of calculi from short- and long-term studies with Sprague-Dawley rats showed that although the incidence of rats with urolithiasis was small (0·5%), the variety of sizes and composition of the calculi could be of general interest.
openaire +3 more sources
Hematoxicity of amodiaquine in sprague-dawley rats
Toxicology International, 2012 The use of amodiaquine (AQ) and its associated toxic effect has been a major public health concern since cases of life-threatening agranulocytosis and hepatic toxicity were reported during its prophylactic use. The objective of this study was to evaluate the hematological safety profile of AQ therapy.Sprague-Dawley rats were randomly distributed into ...
RE Akhigbe +3 more
openaire +3 more sources
Keishibukuryogan is not carcinogenic in Sprague-Dawley rats
Journal of Toxicologic Pathology, 2016 Keishibukuryogan is a traditional Japanese medicine widely administered to patients with menopausal symptoms. Because humans use it on a long-term basis, we believed that a carcinogenicity study was warranted. We orally administered keishibukuryogan (TJ-25) extract powder to 6-week-old Sprague-Dawley rats [Crl:CD(SD)], which were divided into four ...
Masanao Kanitani +3 more
openaire +4 more sources
Ovarian Neoplasia in the Sprague-Dawley Rat [PDF]
Environmental Health Perspectives, 1987 Macroscopic and microscopic characteristics of 210 spontaneous ovarian tumors from 7748 Sprague-Dawley rats are described. The tumors were classified as tubular adenoma, anaplastic adenocarcinoma, papillary cystadenoma, papillary cystadenocarcinoma, mesothelioma, sertoliform tubular adenoma, Sertoli's cell tumor, granulosa cell tumor, thecal cell tumor,
openaire +3 more sources
Spontaneous Odontoameloblastoma in a Female Sprague Dawley Rat [PDF]
Journal of Veterinary Diagnostic Investigation, 2010 The present report describes a spontaneously developing, highly infiltrative, and expansile neoplasm in the mandible of a 9-month-old female Sprague Dawley rat. The lesion consisted of abundant odontogenic epithelium with induction of osteodentin in the adjacent mesenchyme and was classified therefore as an odontoameloblastoma.
Eric R. Burrough +2 more
openaire +3 more sources
Systemic candidiasis in Sprague-Dawley rats [PDF]
Medical Mycology, 1996 A reproducible model of a generalized Candida albicans infection was established in rats to allow a precise evaluation of the efficacy of antifungal compounds. In contrast to the intravenous C. albicans model in mice, which serves as a primary model for in vivo efficacy studies of antimycotic compounds, the infectious process in Sprague-Dawley rats is ...
openaire +3 more sources
Spontaneous Iron Overload in Sprague-Dawley Rats [PDF]
Toxicologic Pathology, 1997 In a review of the toxicological studies performed in our laboratory during the period 1986-1995, we occasionally observed significant iron overloading in the liver. Liver tissue was examined by light and electron microscopy, and the results were analyzed by sex and age (7, 9, 11, 19, 31, 59, and 111 wk).
Nigel Roome, Régis Masson
openaire +3 more sources
Splenic Hemangiosarcoma in a Young Sprague-Dawley Rat
Journal of Toxicologic Pathology, 2012 The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle- to oval-shaped cells that showed invasive growth without ...
Satoru Kajikawa +6 more
openaire +3 more sources
Cutaneous Hybrid Cyst in a Sprague-Dawley Rat
Journal of Toxicologic Pathology, 2012 This report describes a spontaneous hybrid cyst in a Sprague-Dawley (SD) rat. A 52-week-old, male SD rat had a cutaneous cyst on the left mystacial pad. Histologically, the cyst wall showed infundibular differentiation with keratohyalin granules in the granular layer and matrical differentiation comprising basaloid epithelial cells with trichohyalin ...
Mariko Shirota +7 more
openaire +4 more sources