Results 201 to 210 of about 207,124 (265)

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Dexmedetomidine attenuates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease in rats by regulating the autophagic pathway. [PDF]

Sci Rep
Ezzat SM, Sharawy MH, Suddek GM.
europepmc   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Tail clamping induces anxiety-like behaviors and visceral hypersensitivity in rat models of non-erosive reflux disease. [PDF]

World J Psychiatry
Lv M, Liu X, Huang KY, Wang YX, Wang Z, Han LL, Che H, Lv L, Wang FY.   +8 more
europepmc   +1 more source

Chlorfenapyr Induces Hepatotoxicity Associated With Oxidative Stress and Mitochondrial Dysfunction Involving Keap1/Nrf2 Signaling

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao, Jia Li, Cheng Li, Hua He, Lipu Deng   +4 more
wiley   +1 more source

Measuring nephron number in the healthy and diabetic rat kidney in vivo using MRI without contrast agents. [PDF]

Am J Physiol Renal Physiol
Baldelomar EJ, Charlton JR, Keilhoz S, Kohn B, Wilson LD, Xiong LI, Garfinkel A, Bennett KM.   +7 more
europepmc   +1 more source

A parametric electrophysiological–transcriptomic map of MscL‐G22S sonogenetic neuromodulation in the rat hippocampus: Toward precision ultrasound neuromodulation

Journal of Intelligent Medicine, EarlyView.
Using a factorial sweep of ultrasound fundamental and pulse repetition frequencies, we built a parametric electrophysiological–transcriptomic map of MscL‐G22S‐mediated hippocampal neuromodulation, providing reference data for precision, parameter‐aware ultrasound neuromodulation.
Xin Li, Bozhan Wang, Chenguang Zheng, Yutao Tian   +3 more
wiley   +1 more source

Metabolism and Excretion of Synthetic Extended Viperin Pathway Deoxydidehydronucleosides in the Sprague-Dawley Rat. [PDF]

J Proteome Res
Sala S, Nitschke P, Castillo AM, Bernal A, Masuda R, Wood JM, Buckler JN, Grove TL, Almo SC, Harris LD, Holmes E, Wist J, Wilson ID, Nicholson JK.   +13 more
europepmc   +1 more source

Peri‐implant disease pathogenesis animal models: Consensus report of Workgroup 1 of the IADR Implantology Research Group Best Evidence Consensus Symposium on Peri‐Implant Disease and Its Treatment

Journal of Periodontology, EarlyView.
Abstract Background The pathogenesis and etiology of peri‐implantitis demand a deeper understanding to lead to successful treatment modalities. Animal models of peri‐implantitis pathogenesis offer unique insights but their translational impact requires consideration of implant biomaterials science.
Georgios Kotsakis, Leonardo Mancini, Panos Afouxenides, Andrea Roccuzzo, IADR IRG Peri‐implantitis Best Evidence Consensus Working Group 1, Tara Aghaloo, Georgios Belibasakis, Nagihan Bostanci, Li Dehua, Nikolaos Donos, Alpdogan Kantarci, Alireza Moshaverinia, Flavia Pirih, Mia Rakic, Frank Schwarz, Sukirth Ganesan   +15 more
wiley   +1 more source

Biochemical, Molecular and Behavioral Changes Induced by High-fat and High-sugar Diets: A Systematic Review of Non-clinical Studies. [PDF]

Mol Neurobiol
Bach C, Souza JV, Oliveira CS, Mello RG, Maria-Ferreira D.   +4 more
europepmc   +1 more source