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Endocardial Schwannomas in the Wistar Rat
Journal of Veterinary Medicine Series A, 2005SummaryEndocardial neoplasms were observed in 13 Wistar rats, 15–30 months old, from a 30‐month inhalation study. Eight of the rats were dissected at 30 months and the other five between 15 and 29 months. Histologically, the lesions in the heart were diagnosed as endocardial schwannomas.
A, Teredesai, T, Wöhrmann
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Genotoxicity of nimesulide in Wistar rats
Drug and Chemical Toxicology, 2013It is mandatory for all new drugs to be tested for their potential genotoxicity in addition to general toxicity testing. Some old drugs have not been tested adequately for their genotoxic effects because these were in use before the local regulations were enforced. According to the material safety database, the toxicological effect of nimesulide is not
Debojyoti, Borkotoky +3 more
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Spontaneous Immunoglomerulonephritis in Wistar Rats
Pathology - Research and Practice, 1980A strain of rats bred at the Nuclear Study Center of Mol (C.E.N.) develops a nephropathy characterized by granular deposition of immunoglobulin and complement in the renal glomeruli and tubules. We have attempted to specify the complement activation pathways (classical or alternate) in this disease by looking for their initial components (C1q, C3 and ...
A, Fridman-Manduzio +2 more
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METABOLISM OF MYOSMINE IN WISTAR RATS
Drug Metabolism and Disposition, 2005The alkaloid myosmine is present not only in tobacco products but also in various foods. Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine. Due to its widespread occurrence, investigations on the metabolism and activation of myosmine are needed for risk ...
Wolfgang, Zwickenpflug +2 more
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MODELING AND SYNTHESIS OF THE WISTAR RAT ELECTROCARDIOGRAM
Journal of Biological Systems, 2023In this work, we present a synthesizer of electrocardiographic signals of the experimental model of the Wistar rat. Firstly, we modeled the P, R, and S waves using Gaussian functions, while for the T-wave, we used a Gumbel function. We validated the proposed model using a Wistar rat electrocardiogram database, which contains 41 animals with 62,907 ...
Caracciolo, Santiago Federico +2 more
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A supernumerary forelimb in a Wistar rat
Laboratory Animals, 1987A fifth limb, quite independent of the others, was found in a pup born in our colony of Wistar rats. The malformation is described.
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The fate of oxalic acid in the Wistar rat
Xenobiotica, 19811. An established procedure for determining oxalate in human urine has been modified for rat urine. The daily excretion of oxalate by the male Wistar rat is 570-650 microgram. 2. Oxalate excretion in rat urine following i.p. administration of [14C]oxalic acid (1-70 mg/kg) has been studied. The rate and degree of excretion are dose-dependent. 3.
A R, Jones, P, Gadiel, D, Stevenson
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Resistance to mineralocorticoids in Wistar-Furth rats
American Journal of Physiology-Heart and Circulatory Physiology, 1997Wistar-Furth rats (WF) do not develop hypertension when treated with salt and mineralocorticoids and therefore may be useful for investigating the mechanisms of mineralocorticoid action and hypertension. In the present studies, we determined vascular and renal responses of WF to mineralocorticoids. Control Wistar rats (W) developed deoxycorticosterone
M E, Ullian +5 more
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Acetaminophen nephrotoxicity in male Wistar rats
Archives of Toxicology, 1992Acute acetaminophen (APAP) nephrotoxicity was studied in male Wistar rats 1 h after different APAP single doses (200, 500 and 1000 mg/kg body wt, i.p.). Significant impairments in glomerular filtration rate (GFR) and clearance of p-aminohippuric acid (ClPAH) were observed in a dose-dependent way, although tubular parameters measured, water and ...
L, Trumper, G, Girardi, M M, Elías
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Induced palatal candidosis in the Wistar rat
Archives of Oral Biology, 1981Palatal candidosis was induced by inoculating Candida albicans 3091 (serotype A) under an acrylic appliance. After 1 week, the palatal epithelium showed acute inflammatory cell infiltration and surface colonization by blastospores. Two weeks after inoculation, the inflammation had increased, micro-abscesses were observed and fungal hyphae penetrated ...
B S, Shakir, M V, Martin, C J, Smith
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