Results 51 to 60 of about 333,799 (287)

Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery

Advanced Healthcare Materials, EarlyView.
This study proposes a novel formulation of decanoate in an ionic liquid inspired drug delivery system. The formulation demonstrates ideal physicochemical and material properties for oral peptide delivery. Findings indicate that choline decanoate (1:2 molar ratio) forms a viscoelastic gel that enables high oral bioavailability of insulin in rats ...
Konstantinos Raptis, Joanne Heade, Cristiana Cunha, Marco van de Weert, Lasse Saaby, Stine Rønholt, Hanne Mørck Nielsen   +6 more
wiley   +1 more source

POTENTIAL OF JAMBLANG (Syzygium cumini L.) LEAF EXTRACT ON BODY WEIGHT OF WISTAR RATS METABOLIC SYNDROME MODEL

Jurnal Riset Kesehatan, 2021
Jamblang (Syzygium cumini L.) leaves contain several phytochemical compounds. These phytochemicals are thought to have roles as antihyperglycemic, antihyperlipidemic, and antioxidant agents.
Ida Nurwati, Risya Cilmiaty AR, Danus Hermawan, Betty Saptiwi, Dyah Ratna Budiani, Jarot Subandono, Martini Martini, Muthmainah Muthmainah, Sarsono Sarsono, Selfi Handayani   +9 more
doaj   +1 more source

Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze [PDF]

, 2012
The role of the histamine H3 receptor (H3R) in anxiety is controversial, due to limitations in drug selectivity and limited validity of behavioral tests used in previous studies. In the present report, we describe two experiments.
Abuhamdah, Rushdie M., Chazot, Paul L., Ennaceur, Abdelkader, Lethbridge, Natasha L., van Rensburg, Ruan   +4 more
core   +1 more source

Automated Transcranial Photobiomodulation in Healthy Rats: Effects on Working Memory and Brain Markers

Advanced Therapeutics, EarlyView.
Transcranial photobiomodulation (PBM) enhances spatial working memory in healthy rats under both continuous and alternating stimulation protocols. At the neural level, PBM modulates cytochrome c oxidase activity, increases prefrontal and hippocampal synaptic markers, and induces region‐specific c‐Fos expression. These effects suggest improved cognitive
Candela Zorzo, Lucía Rodríguez‐Fernández, Emily Gabriela Castillo‐Escalona, Juan A. Martínez, Laura Mañas, Natalia Arias, Jorge L. Arias   +6 more
wiley   +1 more source

Dilated cardiomyopathy in a wistar rat.

Journal of Toxicologic Pathology, 1995
A 57-week-old male Wistar rat died one week before the end of a toxicity study. Necropsy revealed subcutaneous edema, hydrothorax, dilatation of all cardiac chambers, and congestion in several organs. Light and electron microscopic examinations revealed myocardial hypertrophy, degeneration, fibrosis, and disruption of myofibrils and variable sized ...
Yoshimasa Okazaki, Osamu Katsuta, Junko Matsumoto, Minoru Tsuchitani   +3 more
openaire   +3 more sources

Non‐Invasive Diagnosis of Chronic Myocardial Infarction via Composite In‐Silico‐Human Data Learning

Advanced Science, EarlyView.
This study presents a non‐invasive machine learning model to identify infarct regions in the left ventricle using cardiac strain data. By combining rodent‐based simulated data with limited human data, the model achieves high accuracy in predicting infarct size and location without the need for gadolinium contrast agents, offering a promising ...
Rana Raza Mehdi, Nikhil Kadivar, Tanmay Mukherjee, Emilio A. Mendiola, Akila Bersali, Dipan J. Shah, George Karniadakis, Reza Avazmohammadi   +7 more
wiley   +1 more source

Clinico-pathology, diagnosis and management of Cysticercus fasciolaris and Hymenolepis diminuta co-infection in wistar rats [PDF]

Veterinary World, 2015
Aim: The present study was undertaken to study the pathology and control of sudden unexplained mortality in wistar rats. Materials and Methods: This study was conducted in a colony of 25 male wistar rats where there was mortality of nine rats.
Y. Damodar Singh , Rahul Singh Arya
doaj   +1 more source

Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex. [PDF]

, 2017
Background/aimsWistar rat dams exposed to limited nesting stress (LNS) from post-natal days (PND) 2 to 10 display erratic maternal behavior, and their pups show delayed maturation of the hypothalamic-pituitary-adrenal axis and impaired epithelial barrier
Biraud, Mandy, Jacobs, Jonathan P, Larauche, Muriel, Mayer, Emeran, Million, Mulugeta, Moussaoui, Nabila, Taché, Yvette   +6 more
core   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Histologic Effects of Carbonated Drinks on Rat Kidney

Journal of Rawalpindi Medical College, 2015
Background: To study the histologic effects of carbonated drinks on rat kidneys Methods: In this experimental animal study histological changes on rat kidney caused by chronic consumption of carbonated drinks were observed.
Ayesha Fahim
doaj