Results 21 to 30 of about 900 (95)

Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study

Viruses, 2021
Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the ...
Manabu Igarashi, Takatsugu Hirokawa, Yoshihiro Takadate, Ayato Takada   +3 more
doaj   +1 more source

Authentication of the R06E Fruit Bat Cell Line

Viruses, 2012
Fruit bats and insectivorous bats are believed to provide a natural reservoir for a wide variety of infectious diseases. Several lines of evidence, including the successful isolation of infectious viruses, indicate that Marburg virus and Ravn virus have ...
Ingo Jordan, Volker Sandig, Vincent J. Munster   +2 more
doaj   +1 more source

Serological Detection of Ebola Virus Exposures in Native Non-human Primates of Southern Nigeria

Journal of Epidemiology and Global Health, 2018
Ebola viruses (family: Filoviridae) are the cause of Ebola virus disease (EVD), a highly fatal illness characterised by haemorrhagic fever syndrome in both humans and non-human primates (NHPs).
B.N. Ogunro, B.O. Olugasa, E.J. Verschoor, A.O. Olarinmoye, I. Theyse, H. Niphuis   +5 more
doaj   +1 more source

Non-Ebola Filoviruses: Potential Threats to Global Health Security

Viruses
Filoviruses are negative-sense single-stranded RNA viruses often associated with severe and highly lethal hemorrhagic fever in humans and nonhuman primates, with case fatality rates as high as 90%.
Yannick Munyeku-Bazitama, Francois Edidi-Atani, Ayato Takada   +2 more
doaj   +1 more source

Homologous and heterologous protection of nonhuman primates by Ebola and Sudan virus-like particles.

PLoS ONE, 2015
Filoviruses cause hemorrhagic fever resulting in significant morbidity and mortality in humans. Several vaccine platforms that include multiple virus-vectored approaches and virus-like particles (VLPs) have shown efficacy in nonhuman primates.
Kelly L Warfield, John M Dye, Jay B Wells, Robert C Unfer, Frederick W Holtsberg, Sergey Shulenin, Hong Vu, Dana L Swenson, Sina Bavari, M Javad Aman   +9 more
doaj   +1 more source

Clinical, Histopathologic, and Immunohistochemical Characterization of Experimental Marburg Virus Infection in A Natural Reservoir Host, the Egyptian Rousette Bat (Rousettus aegyptiacus)

Viruses, 2019
Egyptian rousette bats (Rousettus aegyptiacus) are natural reservoir hosts of Marburg virus (MARV), and Ravn virus (RAVV; collectively called marburgviruses) and have been linked to human cases of Marburg virus disease (MVD). We investigated the clinical
Megan E.B. Jones, Brian R. Amman, Tara K. Sealy, Luke S. Uebelhoer, Amy J. Schuh, Timothy Flietstra, Brian H. Bird, JoAnn D. Coleman-McCray, Sherif R. Zaki, Stuart T. Nichol, Jonathan S. Towner   +10 more
doaj   +1 more source

Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification

Nature Communications
Filoviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Yi-Zong Lee, Yi-Nan Zhang, Maddy L. Newby, Garrett Ward, Keegan Braz Gomes, Sarah Auclair, Connor DesRoberts, Joel D. Allen, Andrew B. Ward, Robyn L. Stanfield, Linling He, Max Crispin, Ian A. Wilson, Jiang Zhu   +13 more
doaj   +1 more source

Cohorts of immature Pteropus bats show interannual variation in Hendra virus serology

Journal of Animal Ecology, Volume 95, Issue 3, Page 521-537, March 2026.
Pteropus bat with offspring, photo taken by Manuel Ruiz‐Aravena. Abstract Understanding the drivers of seasonal disease outbreaks remains a fundamental challenge in disease ecology. Periodic outbreaks can be driven by several seasonally varying factors, including pulses of susceptible individuals through births, changes in host behaviour and social ...
Daniel E. Crowley, Caylee A. Falvo, Chris K. Grant, Benny Borremans, Tamika J. Lunn, Manuel Ruiz‐Aravena, Evelyn Benson, Clifton D. McKee, Daniel J. Becker, Devin N. Jones, Trenton Bushmaker, Y. Tina Yu, Michelle Michie, Adrienne S. Dale, Lianying Yan, Spencer L. Sterling, Christopher C. Broder, Laura B. Goodman, Rasa Petraityte‐Burneikiene, Eric D. Laing, Ina L. Smith, Vincent J. Munster, Agnieszka Rynda‐Apple, Alison J. Peel, Raina Plowright   +24 more
wiley   +1 more source

Metabolic Functions and Mechanisms of Selenium, Selenocysteine, and GPX4 Mediated Immune Regulation Through Autophagy in Solid Tumors

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This paper focuses on selenium, selenocysteine, and GPX4, elaborating on their metabolic functions and mechanisms in mediating immune regulation through autophagy in solid tumors. It explores the characteristics of selenium metabolism in tumors and the roles of related enzymes, providing new directions for cancer treatment.
Liang Yang, Yu Jiang, Haoyue Wu, Jinnan Sun, Xinyue Huang, Jingfeng Hong, Bin Zheng, Jinmiao Zhu   +7 more
wiley   +1 more source

Development of a model for marburgvirus based on severe-combined immunodeficiency mice

Virology Journal, 2007
The filoviruses, Ebola (EBOV) and Marburg (MARV), cause a lethal hemorrhagic fever. Human isolates of MARV are not lethal to immmunocompetent adult mice and, to date, there are no reports of a mouse-adapted MARV model. Previously, a uniformly lethal EBOV-
Kalina Warren V, VanTongeren Sean, Reed Daniel K, Bradfute Steven B, Alves Derron A, Warfield Kelly L, Olinger Gene G, Bavari Sina   +7 more
doaj   +1 more source