Results 41 to 50 of about 765,254 (255)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Rice Husk Hydrolytic Lignin Transformation in Carbonization Process

Molecules, 2019
Lignin processing products have an extensive using range. Because products properties depend on lignin precursor quality it was interesting to study lignin isolated from rice husk being a large tonnage waste of rice production and its structural ...
Svetlana Yefremova, Abdurassul Zharmenov, Yurij Sukharnikov, Lara Bunchuk, Askhat Kablanbekov, Kuanish Anarbekov, Tetiana Kulik, Alina Nikolaichuk, Borys Palianytsia   +8 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effect of B4C particle size on the mechanical properties of B4C reinforced aluminum matrix layered composite

Science and Engineering of Composite Materials, 2019
Reinforcement particle size is very important for the performance of metal ceramic composites. This work studied the influence of B4C particle size on the mechanical properties of Al matrix layered composites.
Xu Guangye, Yu Yingshui, Zhang Yubo, Li Tingju, Wang Tongmin   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Development of a lytic Ralstonia phage cocktail and evaluation of its control efficacy against tobacco bacterial wilt

Frontiers in Plant Science
IntroductionBacterial wilt (BW) caused by Ralstonia pseudosolanacearum is a devastating soil-borne disease. Bacteriophages are important biocontrol resources that rapidly and specifically lyse host bacteria, showing good application potential in ...
Haoxin He, Ke Yi, Lei Yang, Yongfeng Jing, Lifu Kang, Zhihao Gao, Dong Xiang, Ge Tan, Yunsheng Wang, Qian Liu, Lin Xie, Shiya Jiang, Tianbo Liu, Wu Chen   +13 more
doaj   +1 more source

Study on Occurrence Status Characteristics of Trace Elements in Imported Indonesia Coals of Shanghai Port Using Inductively Coupled Plasma-Mass Spectrometry and Atomic Fluorescence Spectrometry

Yankuang ceshi, 2015
Indonesia is the largest coal importer of China. In this paper, the concentrations of 12 elements in 31 imported Indonesia coal samples were determined using inductively coupled plasma mass spectrometry (ICP-MS), atomic fluorescence spectrometry (AFS ...
LIU Shu, SHEN Jie, ZHOU Hai-min, ZHU Xiu-fen, ZHU Zhi-xiu, LI Chen, LAN Chao   +6 more
doaj   +1 more source

Based on metabolomics, the optimum wind speed process parameters of flue-cured tobacco in heat pump bulk curing barn were explored

Scientific Reports, 2023
To explore the influence of wind speed on the quality of tobacco in this study, we employed a heat pump-powered intensive curing barn and a three-stage curing process.
Cheng Lin Sun, Hui Lin Zhang, Dong Bo Zhou, Zhi Jun Cheng, You Xie, Zhong Wen Rang, Lin Jian Dai   +6 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Influence of casting speed on fabricating Al-1%Mn and Al-10%Si alloy clad slab

Science and Engineering of Composite Materials, 2017
In this paper, the effect of casting speed on fabricating Al-1%Mn and Al-10%Si alloy clad slab was investigated. Before the trials with the semi-continuous casting process were conducted, a series of simulation with the engineering software FLUENT was ...
Yu Yingshui, Jie Jinchuan, Sun Jianbo, Li Tingju   +3 more
doaj   +1 more source