Results 91 to 100 of about 2,511,664 (300)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Fabricating subscale components for application to full-scale parts [PDF]

, 1970
Equipment requirements and fabrication methods required for manufacture of large cylindrical boron/epoxy shroud are based on subscale component production methods.

core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Study of the dependence of component composition - degree of wastewater purification by adsorbents based on plant raw materials to control the content of priority pollutants in water bodies [PDF]

BIO Web of Conferences
In conditions of intensive development of industrial and agricultural production, measures aimed at protecting the hydrosphere from harmful substances are becoming increasingly important every year.
Myrzalieva S.K., Bagasharov Zh.T., Akilbekova Sh.K., Serikbaev P.C., Isagaliev Kh.G.   +4 more
doaj   +1 more source

Reusable silica surface-insulation material [PDF]

, 1973
Material was specifically developed for manufacture of insulating tiles, but it can be molded into other shapes as required. Basic raw materials are high-purity silica fiber, fumed-silica powder, and reagent-grade starch.
Goldstein, H. E., Leiser, D., Smith, M.
core   +1 more source

Traceability System Model for Quality Gelatin Raw Material of Cattle Hides [PDF]

, 2010
Several criteria must be accomplished within the provision of quality products in terms of the types of materials, the processing methods and effort to get it.
Md Ahsan (3777259), Md Bhuiyan (3777262), Md Hossain (3777274), Md Islam (257385), Md Rahim (3777268), Md Rahman (3449075), Md Saleh-e-In (3777265), Nasim Sultana (3777277), Sudhangshu Kumar Roy (3777271)   +8 more
core   +5 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Analysis of biopharma raw materials by electrophoresis microchips with contactless conductivity detection [PDF]

, 2009
Detailed information concerning the composition of the raw materials employed in the production of biologics is important for the efficient control and optimization of bioprocesses.
Benito-Lopez, Fernando, Diamond, Dermot, Garcia-Cordero, Jose L., Ricco, Antonio J., Vázquez, Mercedes   +4 more
core  

Raw materials price rise easing off [PDF]

, 2008
Due to the slow-down in the worldwide increase in business activity, the growth of demand for raw materials is expected to decelerate.
Kolbe, Heinz
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source