Results 71 to 80 of about 6,463,591 (296)

Treatment of flue gas and coal to reduce air pollution-overview [PDF]

Podzemni Radovi
This paper presents the procedures that can be used to reduce air pollution that originates from the burning of fossil fuels. Research has shown that burning coal is the largest source of emissions of greenhouse gases such as carbon dioxide, sulfur ...
Mihajlović Slavica R., Đorđević Nataša G., Matijašević Srđan D., Kašić Vladan D.   +3 more
doaj   +1 more source

The valorization impact and methods for treatment of non ferrous secondary raw materials [PDF]

Tehnika, 2017
Production of non ferrous metals from secondary raw materials is far less costly than its production from primary raw materials, due to lower energy consumption.
Sokić Miroslav, Marković Branislav, Matković Vladislav, Gulišija Zvonko, Manojlović Vaso, Štrbac Nada   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Raw materials engineering: challenges, technologies and strategies for sustainable resource management

Mineral raw materials constitute the basis for the development of nearly every branch of the manufacturing industry, while the availability of domestic mineral resources is a key factor ensuring the stable and secure development of the national economy ...
Patyk, Michał, Skrzypkowski, Krzysztof, Saramak, Daniel   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Comprehensive characterization of natural bentonite clay: Implications for enhanced performance in ceramics manufacturing [PDF]

Science of Sintering
Potential industrial applications of bentonite from a regional deposit were investigated. The material was investigated beyond state-of-the-art to optimize its quality for use in ceramic sector. Representative bentonite samples (B1, B2, B3) were analyzed.
Radulović Dragan, Marković Marija, Stojanović Jovica, Terzić Anja, Ivošević Branislav, Živanović Vladimir, Božović Darko   +6 more
doaj   +1 more source

Critical variability exists in the digestible value of raw materials fed to black tiger shrimp, Penaeus monodon: The characterisation and digestibility assessment of a series of research and commercial raw materials [PDF]

, 2018
The digestibility of a suite of raw materials was determined when fed to black tiger shrimp (Penaeus monodon) in a series of three experiments. A total of 29 commercial and research raw materials were evaluated using the diet replacement digestibility ...
Glencross, Brett, Brett Glencross, Arnold, Stuart, Nick Wade, Blyth, David, Wade, Nick, Stuart Arnold, David Blyth   +7 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source