Results 51 to 60 of about 8,657 (176)

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Cold Weather Recreational Activities and Raynaud’s Phenomenon

, 2020
Outdoor recreational activities can help people maintain their physical and mental health. Participation in recreational activities has a greater benefit to socialize and meet other people which individuals would normally not have contact within their ...
Mirbod, Seyed Mohammad, 19649
core  

Raynaud’s phenomenon — the clinical picture, treatment and diagnostics

, 2017
Raynaud’s phenomenon is the triphasic phenomenon which consists of sudden paling of distal parts of the body with the following cyanosis and occurance of erythema in the third stage. This phenomenon is a result of peripheral microcirculation disorder and
Lagun, Zuzanna, Marek Roszkiewicz, Elzbieta Szymanska, Aleksandra Malewska, Zuzanna Lagun, Malewska, Aleksandra, Roszkiewicz, Marek, Szymanska, Elzbieta, Wieczorek, Marta, Marta Wieczorek, Walecka, Irena, Irena Walecka   +11 more
core   +1 more source

Mediators in cardiovascular disease: association with Raynaud’s phenomenon [PDF]

, 2021
Raynaud’s phenomenon (RP), often the first presenting sign of SSc-related vasculopathy,is a frequently occurring disorder, and most studies in the general population reporteda prevalence rate of 3%–5%.
Eman Abdulle, Amel; id_orcid, Eman Abdulle, Amel   +1 more
core   +1 more source

Long Noncoding RNA H19 Mediates STAT3‐Dependent Activation of Keratinocytes and Fibroblasts in Systemic Sclerosis Skin

Arthritis &Rheumatology, EarlyView.
Objective Dermal systemic sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with long noncoding RNA (lncRNA) H19 highlighted as the most up‐regulated RNA in their cargo compared with healthy controls (HCs). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz, Christopher W. Wasson, Rebecca L. Ross, Francesco Del Galdo   +3 more
wiley   +1 more source

Long-term effects of cyclic therapy with iloprost in systemic sclerosis

Reumatismo, 2011
Objective: To assess the long-term effects of cyclic infusion of iloprost, a derivative of prostacyclin, on Raynaud’s phenomenon- related symptoms and ischemic ulcers in patients with Systemic Sclerosis (SSc).
A. Grottolo, A. Frigè, E. Danieli, M. Rossi, M. Scarsi, A. Zambruni, P. Airò   +6 more
doaj   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, Accepted Article.
Background Type I interferonopathies are heterogeneous diseases driven by dysregulated IFN‐I signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. Objective To characterize the clinical, immunological, genetic, molecular profiles of patients with suspected enhanced IFN‐I signaling, and assess ...
Ismail Yaz, Seza Ozen, Hacer N. Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet E. Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet O. Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

A case of Raynaud's phenomenon of toes induced by whole‐body warm stimulation

Journal of General and Family Medicine, 2022
Raynaud's phenomenon, induced by cold stimulation and emotional stress, is also induced by whole‐body warm stimulation. A 74‐year‐old man was referred to our department because of nocturnal toe pain from 2 years prior and immediate color change of the ...
Takashi Akimoto, Tadashi Kobayashi, Hiroki Maita, Hiroshi Osawa, Hiroyuki Kato   +4 more
doaj   +1 more source

Nail Disorders in Systemic Conditions

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail findings in children can be indicative of an underlying systemic disease. Many of these findings are seen in multiple entities and are not specific to one disease. The importance of specifically examining for these nail changes cannot be overstated.
Jane Sanders Bellet
wiley   +1 more source