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The natural history of progressive myoclonus ataxia
Neurobiology of DiseaseProgressive myoclonus ataxia (PMA) is a rare clinical syndrome characterized by the presence of progressive myoclonus and ataxia, and can be accompanied by mild cognitive impairment and infrequent epileptic seizures.
Sterre van der Veen +6 more
doaj +1 more source
Emotion Recognition in Patients with Low-Grade Glioma before and after Surgery
Brain Sciences, 2022 Research on patients with low-grade gliomas (LGGs) showed neurocognitive impairments in various domains. However, social cognition has barely been investigated.
Anne M. Buunk +6 more
doaj +1 more source
Regulation of RB Transcription In Vivo by RB Family Members [PDF]
Molecular and Cellular Biology, 2010 In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivated by mutation in the RB gene or functionally inhibited by abnormal activation of cyclin-dependent kinase activity. While variations in RB levels may also provide an important means of controlling RB function in both normal and cancer cells, little is known about the ...
Deborah L, Burkhart +7 more
openaire +2 more sources
Absolute Absorption and Dispersion in a Thermal Rb Vapour at High Densities and High Magnetic Fields. [PDF]
, 2013 This thesis presents a comparative study of the measured and calculated absolute absorption and dispersion properties of the Rb D lines through a dense thermal vapour in the absence and presence of an applied magnetic field.
WELLER, LEE
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
DiagnosticsBackground: In prenatal genetic diagnostics, the detection of single-gene defects relies on chorionic villus sampling (CVS) and amniocentesis, which carry a miscarriage risk of 0.2–0.3%. To mitigate this risk, fetal trophoblasts have been isolated from a
Eddy N. de Boer +10 more
doaj +1 more source
Feshbach spectroscopy of an ultracold Rb-Cs mixture [PDF]
, 2012 This thesis reports the observation of interspecies Feshbach resonances in an ultracold mixture of Rb and Cs atoms. A versatile combined magnetic and optical potential has been designed and constructed which is capable of bringing both $^{87}\rm{Rb}$ and
Jenkin, Daniel Lester +2 more
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer
Clinical and Developmental Immunology, 2010 The prognosis of epithelial ovarian cancer (EOC), the primary cause of death from gynaecological malignancies, has only modestly improved over the last decades.
Renee Vermeij +9 more
doaj +1 more source