Results 31 to 40 of about 389,945 (292)
Genes & Development, 2013 The retinoblastoma tumor suppressor RB is well known for its capacity to restrict cell cycle progression at the G1/S transition of the cell cycle by controlling the transcription of cell cycle genes. In this issue of Genes & Development, Hilgendorf and colleagues (pp.
Laura D, Attardi, Julien, Sage
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TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21(Cip1) or Rb status [PDF]
, 2008 Melville Trust for the Care and Cure of Cancer to SP and SS.Background: TGF beta has pleiotropic effects that range from regulation of proliferation and apoptosis to morphological changes and epithelial-mesenchymal transition (EMT).
Sharon Sheahan +14 more
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Revisiting perfect fluid dark matter: Observational constraints from our galaxy
Physics Letters B, 2016 We revisit certain features of an assumed spherically symmetric perfect fluid dark matter halo in the light of the observed data of our galaxy, the Milky Way (MW). The idea is to apply the Faber–Visser approach of combined observations of rotation curves
Alexander A. Potapov +2 more
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Transport of Rb and Sr to the ear in mature, excised shoots of wheat: Effects of temperature and stem length on Rb removal from the xylem [PDF]
, 1991 Wheat (Triticum aestivum L. cv. `Arina') shoots grown in the field were excised post-anthesis and incubated in the laboratory for 72 h standing in 2 mM RbCl + 2 mM SrCl2. Strontium is a phloem-immobile, xylem-mobile element and indicates the distribution
Kuppelwieser, H, Feller, Urs
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Indian Journal of Pathology and MicrobiologyObjective: To investigate the molecular characteristics of Rb/E2F in mixed adeno-neuroendocrine carcinoma (MANEC). Materials and Methods: The clinicopathological features of MANEC were analyzed.
Feng Ling, Zhihui Yang
doaj +1 more source
Super solutions of the model RB
Frontiers of Computer Science, 2022 The concept of super solution is a special type of generalized solutions with certain degree of robustness and stability. In this paper we consider the $(1,1)$-super solutions of the model RB. Using the first moment method, we establish a "threshold" such that as the constraint density crosses this value, the expected number of $(1,1)$-super solutions ...
Guangyan Zhou, Wei Xu
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Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest [PDF]
, 2007 Background TGFβ is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Dunbar, Donald R +14 more
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Survey response in colorectal surgery. A systematic review
Surgery in Practice and Science, 2022 Background: Survey research is widely used for developing value-based management strategies in colorectal surgery. However, declining response rates threaten the validity of results.
Vincent M. Meyer +5 more
doaj +1 more source
Loss of Rb Cooperates with Ras to Drive Oncogenic Growth in Mammalian Cells [PDF]
, 2012 Background The p53, Rb, and Ras/PI3K pathways are implicated in the development of the majority of human cancers. A number of studies have established that these pathways cooperate at the level of the cell cycle leading to loss of normal proliferative ...
Sara Ribeiro +4 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source