Results 11 to 20 of about 9,748 (50)

FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements[S]

Journal of Lipid Research, 2019
The bile acid-activated nuclear receptor, FXR (NR1H4), has been implicated in the control of lipid and energy metabolism, but its role in fat tissue, where it is moderately expressed, is not understood.
Tim van Zutphen, Johanna H.M. Stroeve, Jiufang Yang, Vincent W. Bloks, Angelika Jurdzinski, Han Roelofsen, Nicolette C.A. Huijkman, Theo H. van Dijk, Roel J. Vonk, Jan van Deursen, Bart Staels, Albert K. Groen, Folkert Kuipers   +12 more
doaj   +1 more source

Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air–Liquid Interface Cultured Human Primary Bronchial Epithelial Cells

Viruses, 2021
The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has an enormous impact on human health and economy.
Bram M. ter Ellen, Nilima Dinesh Kumar, Ellen M. Bouma, Berit Troost, Denise P.I. van de Pol, Heidi H. van der Ende-Metselaar, Leonie Apperloo, Djoke van Gosliga, Maarten van den Berge, Martijn C. Nawijn, Peter H.J. van der Voort, Jill Moser, Izabela A. Rodenhuis-Zybert, Jolanda M. Smit   +13 more
doaj   +1 more source

Release of High-Mobility Group Box-1 after a Raynaud’s Attack Leads to Fibroblast Activation and Interferon-γ Induced Protein-10 Production: Role in Systemic Sclerosis Pathogenesis

Antioxidants, 2023
Raynaud’s Phenomenon (RP) leading to repetitive ischemia and reperfusion (IR) stress, is the first recognizable sign of systemic sclerosis (SSc) leading to increased oxidative stress.
Yehya Al-Adwi, Isabella M. Atzeni, Berber Doornbos-van der Meer, Amaal Eman Abdulle, Anniek M. van Roon, Alja Stel, Harry van Goor, Andries J. Smit, Johanna Westra, Douwe J. Mulder   +9 more
doaj   +1 more source

Serum levels of bone turnover markers including calculation of Z-scores: Data from a Dutch healthy reference cohort

Bone Reports, 2023
Introduction: Bone turnover markers (BTM) are biochemical compounds reflecting different stages of bone metabolism. Their levels change with age and differ between males and females.
Mark Siderius, Suzanne Arends, Anneke Muller Kobold, Lucie Wagenmakers, Karin Koerts, Anneke Spoorenberg, Eveline van der Veer   +6 more
doaj   +1 more source

Development and Characterisation of Antibody-Based Optical Imaging Probes for Inflammatory Bowel Disease

Pharmaceuticals, 2021
Monoclonal antibodies are an important addition to the medicinal treatment paradigm for IBD patients. While effective, these agents show a high degree of primary and secondary non-response, and methods to predict response are highly desired.
Matthijs David Linssen, Wouter Tjerk Rudolph Hooghiemstra, Annelies Jorritsma-Smit, Derk Pieter Allersma, Gerard Dijkstra, Wouter Bastiaan Nagengast   +5 more
doaj   +1 more source

Gifted and Average-Ability Children’s Potential for Solving Analogy Items

Journal of Intelligence, 2019
Analogical reasoning is assumed to play a large role in learning and problem solving in everyday and school settings. It was examined whether a newly developed dynamic test of analogical reasoning would be sufficiently difficult for identifying young ...
Bart Vogelaar, Sophie W. Sweijen, Wilma C. M. Resing   +2 more
doaj   +1 more source

Image Quality and Interpretation of [¹⁸F]-FES-PET: Is There any Effect of Food Intake?

Diagnostics, 2020
Background: High physiological 16α-[18F]-fluoro-17β-estradiol ([18F]-FES) uptake in the abdomen is a limitation of this positron emission tomography (PET) tracer.
Jorianne Boers, Katerina Giatagana, Carolina P. Schröder, Geke A.P. Hospers, Erik F.J. de Vries, Andor W.J.M. Glaudemans   +5 more
doaj   +1 more source

Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma

Neoplasia: An International Journal for Oncology Research, 2016
SET domain-containing 2 (SETD2) is responsible for the trimethylation of histone H3 lysine36 (H3K36me3) and is one of the genes most frequently mutated in clear cell renal cell carcinoma (ccRCC).
Jun Li, Joost Kluiver, Jan Osinga, Helga Westers, Maaike B van Werkhoven, Marc A. Seelen, Rolf H. Sijmons, Anke van den Berg, Klaas Kok   +8 more
doaj   +1 more source

On the hoop conjecture in Einstein gravity coupled to nonlinear electrodynamics

Physics Letters B, 2020
The famous hoop conjecture by Thorne has been claimed to be violated in curved spacetimes coupled to linear electrodynamics. Hod [1] has recently refuted this claim by clarifying the status and validity of the conjecture appropriately interpreting the ...
K.K. Nandi, R.N. Izmailov, G.M. Garipova, R.R. Volotskova, A.A. Potapov   +4 more
doaj   +1 more source

Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies

Diagnostics, 2021
The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV).
Gijs D. van Praagh, Pieter H. Nienhuis, Daniel M. de Jong, Melanie Reijrink, Kornelis S. M. van der Geest, Elisabeth Brouwer, Andor W. J. M. Glaudemans, Bhanu Sinha, Antoon T. M. Willemsen, Riemer H. J. A. Slart   +9 more
doaj   +1 more source