Results 81 to 90 of about 389,945 (292)

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph   +5 more
wiley   +1 more source

Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study

open access: yesArthritis Care &Research, EarlyView.
Objective Social determinants of health (SDOH) contribute to juvenile idiopathic arthritis (JIA) disparities, but most studies have assessed SDOH independently rather than cumulatively across individual, family, and neighborhood levels. Using a socioecological framework, we investigated the relationship among cumulative social disadvantage ...
William Daniel Soulsby   +448 more
wiley   +1 more source

Factors influencing the development and implementation of a prehabilitation program for kidney transplant candidates: A mixed-methods contextual analysis

open access: yesInternational Journal of Nursing Studies Advances
Background: Kidney transplantation is the preferred treatment for kidney failure. However, kidney transplant candidates often experience a decline in health while awaiting transplantation due to disease progression, comorbidities, and negatives effects ...
Avril J. Haanstra   +8 more
doaj   +1 more source

Generation of Rb-iPSCs from transgenic Rb-NSCs.

open access: yes, 2014
(A) Experimental outline for generating Rb-iPSCs from Rb-NSCs. (B) The morphology of NSCs changed to multi-layer compacted clones after 11 days of induction using human transcription factors Oct4, Klf4, Sox2 and c-Myc.
Quanjun Zhang (652763)   +9 more
core   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

open access: yesArthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel   +6 more
wiley   +1 more source

Abnormal hemostatic function one year after orthotopic liver transplantation can be fully attributed to endothelial cell activation [v2; ref status: indexed, http://f1000r.es/40n]

open access: yesF1000Research, 2014
Background: The long-term risk of thrombotic and vascular complications is elevated in liver transplant recipients compared to the general population.
Freeha Arshad   +5 more
doaj   +1 more source

Neighborhood Socioeconomic Status and Short‐Term Functional Outcomes in Systemic Lupus Erythematosus

open access: yesArthritis Care &Research, EarlyView.
Objective Individuals with systemic lupus erythematosus (SLE) can accumulate functional status (FS) impairment. We evaluated the association between neighborhood socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI), and FS in a national SLE sample.
Baljeet Rai   +7 more
wiley   +1 more source

The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival

open access: yes, 2005
Although the retinoblastoma susceptibility gene RB1 is inactivated in a wide variety of human cancers, the retinoblastoma protein (Rb) has been shown to be overexpressed in colon cancers, which is linked to the anti-apoptotic function of the protein ...
Arhel, NJ   +14 more
core  

Validation of Patient‐Reported Outcomes Measurement Information System (PROMIS) Pediatric Measures for Children With Chronic Nonbacterial Osteomyelitis

open access: yesArthritis Care &Research, EarlyView.
Objective To assess the validity of the Patient‐Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in patients with chronic nonbacterial osteomyelitis (CNO). Methods Within the longitudinal patient registry of CNO, English‐speaking patients aged 8 years and older self‐reported PROMIS Pediatric measures of fatigue, pain ...
Mary M. Eckert   +43 more
wiley   +1 more source

The cholinergic system is involved in cervical dystonia – An [18F]FEOBV PET study

open access: yesNeurobiology of Disease
Background: Cervical dystonia (CD) is a movement disorder characterized by involuntary muscle contractions that result in abnormal head postures and movements.
S.A.J.E.A. Lagerweij   +8 more
doaj   +1 more source

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