Lamotrigine Withdrawal may Worsen RBD Symptoms
Rapid eye movement (REM) behavior disorder (RBD) is a rapid eye movement parasomnia, which in its symptomatic type could be induced by the introduction or the discontinuation of several drugs and substances. No references for antiepileptic drugs and especially for lamotrigine are known regarding pharmacologically induced RBD.We report a case of a 68 ...
Economou NT +5 more
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Получение и характеристика гомодимерной формы RBD S-белка SARS-CoV-2, обладающей повышенной авидностью к специфическим антителам [PDF]
Monitoring of the proportion of immune individuals and the effectiveness of vaccination in a population involves evaluation of several important parameters, including the level of virus-neutralising antibodies.
Е. И. Рябова +15 more
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Fragment Molecular Orbital Based Interaction Analyses on Complexes Between RBD Variants and ACE2 [PDF]
The spike protein plays an important role in the infection of SARS-CoV-2 to human cells, and the binding affinity of receptor binding domain (RBD) to angiotensin-converting enzyme 2 (ACE2) is of special interest.
Shun, Kitahara +5 more
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Covalent Bonding Aptamer with Enhanced SARS-CoV-2 RBD-ACE2 Blocking and Pseudovirus Neutralization Activities [PDF]
SARS-CoV-2 uses its spike protein receptor-binding domain (RBD) to interact with the angiotensin-converting enzyme 2 (ACE2) receptor on host cells. Inhibitors of the RBD-ACE2 interaction are therefore promising drug candidates in treating COVID-19. Here,
Yu, Xiang, Zichen, Qin, Yiying, Zhu
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Correlations of the neutralizing antibody (NAb) with anti-RBD-Ab and anti-NC-Ab.
(A) Correlation between the NAb and the anti-receptor-binding domain antibody (anti-RBD-Ab). The cutoff for anti-RBD-Ab, Log10 (0.8) = ‒0.0969, is not shown in the graph. Spearman’s rank correlation coefficient: 2M: rho = 0.739; 6M: rho = 0.707; 12M: rho
Tomomi Maeno (13531596) +9 more
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RBD-Ig neutralizes in-vitro infection regardless of SARS-CoV-2 titers.
(A) Staining of 293T-Parental cells and 293T-ACE2 cells with the mAb anti-ACE2 01 we generated. (B) Staining of 293T-Parental cells and 293T-ACE2 cells with RBD-Ig.
Orit Berhani (11136072) +15 more
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An Engineered HR1-Stem Helix-HR2 Trimeric Platform for Developing Broad-Spectrum Coronavirus Vaccines. [PDF]
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Sun X +18 more
europepmc +2 more sources
Diversity of Alpha-RBD library.
Distribution of number of mutations per RBD. Following transformation with plasmid containing whole Alpha spike with the RBD library, 50 colonies, were picked, mini prepped and Sanger sequenced across the RBD, the number of mutations in each RBD is shown
Paul Kellam (6413) +4 more
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Structural comparison of Y453F RBD/mink ACE2 and WT RBD/human ACE2 complexes.
(A)The overall structure is shown as ribbons. The Y453F-RBD is shown in cyan and mink ACE2 in green. The WT-RBD and human ACE2 are shown in magenta and orange, respectively. (B) Interaction residues around position 34 of human and mink ACE2.
Rong Zhang (44942) +14 more
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Equivalent expressions and performance analysis of SLNR precoding schemes: a generalisation to multi-antenna receivers [PDF]
In this letter, equivalent expressions of transmit precoding solutions based on the maximum signal-to-leakage-plus-noise ratio (SLNR) are derived for multiuser MIMO systems with multi-antenna receivers.
Armour, Simon M D +2 more
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