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Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies
Acta Pharmaceutica Sinica B, 2023 Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs.
Yingying Hou +5 more
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Vaccines, 2023 Previous studies have shown that the herpes zoster subunit vaccine Shingrix™ performs well in clinical trials. However, the key ingredient in its adjuvant, QS21, is extracted from rare plants in South America, so vaccine production is limited.
Kangyang Lin +5 more
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Poultry Science: Outbreaks of hepatitis-hydropericardium syndrome (HHS) caused by fowl adenovirus serotype 4 (FAdV-4) have resulted in huge economic losses to the poultry industry in China since 2015.
Shuaifeng Liu +6 more
doaj +3 more sources
VaccinesBackground: Currently, the recombinant subunit vaccine and live attenuated vaccine in the prevention of herpes zoster are approved for marketing in China.
Jiaqi Wang +5 more
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Evaluating passive immunity in piglets from sows vaccinated with a PEDV S protein subunit vaccine
Frontiers in Cellular and Infection MicrobiologyPorcine epidemic diarrhea virus (PEDV) is a highly contagious virus that causes severe diarrhea and high mortality in neonatal piglets. Current control measures, such as inactivated and live-attenuated vaccines, have limitations in providing complete ...
Jiajia Liu +13 more
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Efficacy Evaluation of an E2 Subunit Vaccine Against Highly Virulent Classical Swine Fever Virus Strain [PDF]
VaccinesBackground/Objectives: Classical swine fever (CSF) is listed by the World Organisation for Animal Health as a highly devastating and contagious pig disease, causing severe economic losses to the swine industry.
Yu-Chieh Chen +5 more
doaj +2 more sources
Fusion membrane proteins derived subunit vaccine candidates effectively protect against Mycoplasma bovis challenge in mice [PDF]
BMC Veterinary ResearchMycoplasma bovis (M. bovis) is the causative agent of bovine mycoplasmosis, a disease that can lead to respiratory issues, otitis media, mastitis, and arthritis in cattle and causes huge economic losses to the cattle breeding industry.
Yong Xuan Wang +8 more
doaj +2 more sources
LDH as an adjuvant makes Brucella outer-membrane vesicles and outer-membrane vesicle-associated proteins highly protective in mice [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Existing Brucella vaccines are attenuated and can cause vaccine-associated brucellosis; and these safety concerns have affected their application.
Xiaoyu Deng +8 more
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A QS21+ CpG-Adjuvanted Rabies Virus G Subunit Vaccine Elicits Superior Humoral and Moderate Cellular Immunity [PDF]
VaccinesBackground: Rabies remains a fatal zoonotic disease caused by rabies virus (RABV), posing substantial global health challenges. Current vaccine production faces challenges in manufacturing efficiency and cost-effectiveness. The RABV glycoprotein (RABV-G)
Han Cao +7 more
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Subunit vaccines for Acinetobacter baumannii
Frontiers in Immunology, 2023 Acinetobacter baumannii is a gram-negative bacterium and a crucial opportunistic pathogen in hospitals. A. baumannii infection has become a challenging problem in clinical practice due to the increasing number of multidrug-resistant strains and their prevalence worldwide. Vaccines are effective tools to prevent and control A. baumannii infection.
Ning Yang +6 more
openaire +3 more sources