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Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies

Acta Pharmaceutica Sinica B, 2023
Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs.
Yingying Hou, Min Chen, Yuan Bian, Xi Zheng, Rongsheng Tong, Xun Sun   +5 more
doaj   +4 more sources

A novel subunit vaccine based on Fiber1/2 knob domain provides full protection against fowl adenovirus serotype 4 and induces stronger immune responses than a Fiber2 subunit vaccine

Poultry Science
: Outbreaks of hepatitis-hydropericardium syndrome (HHS) caused by fowl adenovirus serotype 4 (FAdV-4) have resulted in huge economic losses to the poultry industry in China since 2015.
Shuaifeng Liu, Xiaofeng Dong, Baishi Lei, Wuchao Zhang, Xiangqin Wang, Wanzhe Yuan, Kuan Zhao   +6 more
doaj   +4 more sources

Cost-Effectiveness Analysis of Herpes Zoster Vaccination in a Chinese Population: Recombinant Subunit Vaccine versus Live Attenuated Vaccine

Vaccines
Background: Currently, the recombinant subunit vaccine and live attenuated vaccine in the prevention of herpes zoster are approved for marketing in China.
Jiaqi Wang, Pengfei Jin, Hui Jin, Qiang Wang, Fengcai Zhu, Jingxin Li   +5 more
doaj   +4 more sources

A single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus

npj Vaccines, 2021
Nipah and Hendra viruses are highly pathogenic bat-borne paramyxoviruses recently included in the WHO Blueprint priority diseases list. A fully registered horse anti-Hendra virus subunit vaccine has been in use in Australia since 2012.
Thomas W. Geisbert, Kathryn Bobb, Viktoriya Borisevich, Joan B. Geisbert, Krystle N. Agans, Robert W. Cross, Abhishek N. Prasad, Karla A. Fenton, Hao Yu, Timothy R. Fouts, Christopher C. Broder, Antony S. Dimitrov   +11 more
doaj   +2 more sources

Advances in Oral Subunit Vaccine Design [PDF]

Vaccines, 2020
Many pathogens invade the host at the intestinal surface. To protect against these enteropathogens, the induction of intestinal secretory IgA (SIgA) responses is paramount.
Hans Van der Weken, E. Cox, B. Devriendt
semanticscholar   +5 more sources

Novel Immunoinformatics Approaches to Design Multi-epitope Subunit Vaccine for Malaria by Investigating Anopheles Salivary Protein

Scientific Reports, 2018
Malaria fever has been pervasive for quite a while in tropical developing regions causing high morbidity and mortality. The causal organism is a protozoan parasite of genus Plasmodium which spreads to the human host by the bite of hitherto infected ...
Rajan Kumar Pandey, Tarun Kumar Bhatt, Vijay Kumar Prajapati   +2 more
doaj   +2 more sources

Recombinant subunit vaccine against Mycoplasma gallisepticum disease confers cross-protection against multiple pathogenic strains [PDF]

Infection and Immunity
Mycoplasma gallisepticum (MG) is an avian respiratory pathogen of global concern, responsible for hundreds of millions of dollars in estimated economic damage each year.
Jeremy M. Miller, Rosemary G. Ozyck, Arlind B. Mara, Esmeralda F. Hernandez, Jessica B. Malek, Edan R. Tulman, Steven M. Szczepanek, Steven J. Geary   +7 more
doaj   +2 more sources

Development and immunogenicity of a novel subunit vaccine candidate against avian metapneumovirus [PDF]

Frontiers in Veterinary Science
ObjectivesaMPV subtype B remains one of the major respiratory pathogens affecting commercial poultry worldwide despite the widespread implementation of vaccination programs.
Urzhan Omarbekova, Aspen Abutalip, Yergali Moldakhanov, Madina Alexyuk, Assylbek Mussoyev, Indira Mussayeva, Andrey Bogoyavlenskiy, Pavel Alexyuk   +7 more
doaj   +2 more sources

Evaluating passive immunity in piglets from sows vaccinated with a PEDV S protein subunit vaccine

Frontiers in Cellular and Infection Microbiology
Porcine epidemic diarrhea virus (PEDV) is a highly contagious virus that causes severe diarrhea and high mortality in neonatal piglets. Current control measures, such as inactivated and live-attenuated vaccines, have limitations in providing complete ...
Jiajia Liu, Jiajia Liu, Guangli Hu, Shengjin Liu, Guangcai Ren, Liguo Gao, Liguo Gao, Zhiqing Zhao, Rui Geng, Dingli Wang, Xiao Shen, Feng Chen, Hanqin Shen, Hanqin Shen   +13 more
doaj   +3 more sources

LDH as an adjuvant makes Brucella outer-membrane vesicles and outer-membrane vesicle-associated proteins highly protective in mice [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Existing Brucella vaccines are attenuated and can cause vaccine-associated brucellosis; and these safety concerns have affected their application.
Xiaoyu Deng, Jinke He, Jinfeng Xu, Yueli Wang, Jihai Yi, Huan Zhang, Yong Wang, Zhen Wang, Chuangfu Chen   +8 more
doaj   +1 more source