Results 11 to 20 of about 1,747,151 (350)

Polymers for subunit vaccine delivery

European Polymer Journal, 2019
Mimicking the size and structural features of a pathogen is critical in developing immunity through subunit vaccines; it has been shown that this can be successfully achieved by nano-sized delivery systems and carriers.
Reshma J. Nevagi, M. Skwarczynski, I. Toth   +2 more
semanticscholar   +2 more sources

Immunogenicity of DNA, mRNA and Subunit Vaccines Against Beak and Feather Disease Virus

Vaccines
Background/Objectives: Beak and feather disease virus (BFDV) is the causative agent of psittacine beak and feather disease (PBFD), affecting psittacine birds. There is currently no commercial vaccine or treatment for this disease.
Buyani Ndlovu, Albertha R. van Zyl, Dirk Verwoerd, Edward P. Rybicki, Inga I. Hitzeroth   +4 more
doaj   +2 more sources

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age-Related Declines in Humoral and Cellular Immunity Relative to Shingrix. [PDF]

Adv Sci (Weinh)
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Song YE, Yan J, Ou BS, Saouaf OM, Eckman N, Appel EA.   +5 more
europepmc   +2 more sources

Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials

Lancet. Infectious Diseases (Print), 2021
Background Although several COVID-19 vaccines have been developed so far, they will not be sufficient to meet the global demand. Development of a wider range of vaccines, with different mechanisms of action, could help control the spread of SARS-CoV-2 ...
Shilong Yang, Yan Li, L. Dai, Jian-feng Wang, P. He, Chang-Gui Li, Xin Fang, Chenfei Wang, Xiang-Na Zhao, E. Huang, Chang-Wei Wu, Z. Zhong, Fengze Wang, Xiaomin Duan, Siyu Tian, Li-Li Wu, Yan Liu, Yi Luo, Zhihai Chen, Fangjun Li, Junhua Li, Xian Yu, H. Ren, Li-Hong Liu, S. Meng, Jinghua Yan, Zhongyu Hu, Li-dong Gao, G. Gao   +28 more
semanticscholar   +1 more source

Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern

Cell Research, 2021
Dear Editor, As of October, 2021, SARS-CoV-2 has infected more than 230 million people; promoting roll-out vaccinations could help build herd immunity for the pandemic.
Jingwen Ai, Haocheng Zhang, Qiran Zhang, Yi Zhang, Ke Lin, Zhangfan Fu, Jieyu Song, Yuanhan Zhao, Mingxiang Fan, Hongyu Wang, C. Qiu, Yang Zhou, Wenhong Zhang   +12 more
semanticscholar   +1 more source

A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin

Nature Communications, 2021
Given the encouraging clinical results of both candidate subunit vaccines and revaccination with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for combining BCG and subunit vaccination for increased efficacy.
J. Woodworth, Helena Strand Clemmensen, Hannah Battey, K. Dijkman, T. Lindenstrøm, R. S. Laureano, R. Taplitz, J. Morgan, C. Aagaard, I. Rosenkrands, C. L. Lindestam Arlehamn, P. Andersen, R. Mortensen   +12 more
semanticscholar   +1 more source

Comparison of the Immune Effects of an mRNA Vaccine and a Subunit Vaccine against Herpes Zoster Administered by Different Injection Methods

Vaccines, 2023
Previous studies have shown that the herpes zoster subunit vaccine Shingrix™ performs well in clinical trials. However, the key ingredient in its adjuvant, QS21, is extracted from rare plants in South America, so vaccine production is limited.
Kangyang Lin, Han Cao, Ning Luan, Yunfei Wang, Jingping Hu, Cunbao Liu   +5 more
doaj   +1 more source

A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

Science Translational Medicine, 2021
A SARS-CoV-2 spike protein subunit vaccine induced humoral and cellular immune responses that protected hamsters against infection and prevented transmission.
Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hua-long Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingwen Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, M. Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yu Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Q. Zheng, Shaowei Li, Yixin Chen, T. Cheng, Jun Zhang, Tianying Zhang, Huachen Zhu, Qinjian Zhao, Q. Yuan, Y. Guan, N. Xia   +35 more
semanticscholar   +1 more source

Hydrogel‐Based Slow Release of a Receptor‐Binding Domain Subunit Vaccine Elicits Neutralizing Antibody Responses Against SARS‐CoV‐2

Advances in Materials, 2021
The development of effective vaccines that can be rapidly manufactured and distributed worldwide is necessary to mitigate the devastating health and economic impacts of pandemics like COVID‐19.
Emily C. Gale, Abigail E. Powell, Gillie A. Roth, Emily L. Meany, Jerry Yan, Ben S. Ou, Abigail K. Grosskopf, J. Adamska, Vittoria C. T. M. Picece, Andrea I. d’Aquino, B. Pulendran, Peter S. Kim, E. Appel   +12 more
semanticscholar   +1 more source

Design of a multi-epitope protein as a subunit vaccine against lumpy skin disease using an immunoinformatics approach

Scientific Reports, 2022
Lumpy skin disease (LSD) is a transboundary viral disease of cattle that causes substantial economic loss globally. There is no specific treatment and subunit vaccine for this disease to date.
P. Kar, Prasanna Babu Araveti, Akshay Kuriakose, A. Srivastava   +3 more
semanticscholar   +1 more source