Results 31 to 40 of about 1,747,151 (350)
Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [PDF]
, 2014 BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Said, Khadija +67 more
core +1 more source
PLoS ONE, 2012 Recent studies have demonstrated the effectiveness of vaccine delivery to the skin by vaccine-coated microneedles; however there is little information on the effects of adjuvants using this approach for vaccination.
William C Weldon +8 more
doaj +1 more source
npj Vaccines, 2022 Protein or peptide-based subunit vaccines have generated excitement and renewed interest in combating human cancer or COVID-19 outbreak. One major concern for subunit vaccine application is the weak immune responses induced by protein or peptides ...
Ning Yang +6 more
doaj +1 more source
A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein
Cell Research, 2022 The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of the current vaccines and antibody therapeutics.
W. Pang +25 more
semanticscholar +1 more source
Carbohydrate Immune Adjuvants in Subunit Vaccines [PDF]
Pharmaceutics, 2020 Modern subunit vaccines are composed of antigens and a delivery system and/or adjuvant (immune stimulator) that triggers the desired immune responses. Adjuvants mimic pathogen-associated molecular patterns (PAMPs) that are typically associated with infections.
Sahra Bashiri +3 more
openaire +6 more sources
PLoS ONE, 2023 Subunit vaccines feature critical advantages over other vaccine platforms such as stability, price, and minimal adverse effects. To maximize immunological protection of subunit vaccines, adjuvants are considered as main components that are formulated ...
Sedthawut Laotee +15 more
doaj +1 more source
Future Path Toward TB Vaccine Development: Boosting BCG or Re-educating by a New Subunit Vaccine
Frontiers in Immunology, 2018 Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb), kills 5,000 people per day globally. Rapid development and spread of various multi drug-resistant strains of Mtb emphasize that an effective vaccine is still the most ...
Nancy Gupta +5 more
doaj +1 more source
Avoiding rash decisions about zoster vaccination: insights from cost-effectiveness evidence
BMC Medicine, 2018 de Boer and colleagues present a cost-effectiveness analysis based in the Netherlands of two vaccines available for the prevention of herpes zoster. Zostavax® was the first vaccine available for the prevention of herpes zoster in older adults.
Chester B. Good +2 more
doaj +1 more source
Raising Expectations For Subunit Vaccine [PDF]
The Journal of Infectious Diseases, 2014 Multidose regimens are recommended for all prophylactic subunit vaccines. Recent findings from clinical trials of an human papillomavirus virus-like particle vaccine suggest that it may be possible to develop effective single-dose subunit vaccines.
John T, Schiller, Douglas R, Lowy
openaire +2 more sources
S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
Nature Communications, 2020 SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells.
Joshua G. Liang +24 more
semanticscholar +1 more source