Results 31 to 40 of about 83,566 (244)

Experimental study of brucella vaccines in mice and guinea pigs, with special references to serological diagnosis of workers in field of vaccine production [PDF]

Benha Veterinary Medical Journal, 2015
In this study, groups of 150 brucella free white Swiss mice, were inoculated with different oilyadjuvanated brucella melitensis subunit vaccines alone or both and then were challenged with Br.melitensis virulent strain for the evaluation of the immune ...
Manal Mohamed, El-Ayouby M., Nashwa Khalifa, Lobna Salem, El-Olemy E.   +4 more
doaj   +1 more source

The Mink Circovirus Capsid Subunit Expressed by Recombinant Baculovirus Protects Minks against Refractory Diarrhea in Field

Viruses, 2021
Mink refractory diarrhea is a seasonal disease that occurs in many mink farms in China. Mink circovirus (MiCV) has been recognized as the causative agent of the disease.
Lidong Wang, Yanyan Zhang, Teng Chen, Lijuan Mi, Xuefei Sun, Xintao Zhou, Faming Miao, Shoufeng Zhang, Ye Liu, Rongliang Hu   +9 more
doaj   +1 more source

Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice

iScience, 2022
Summary: Efficient delivery of subunit vaccines to dendritic cells (DCs) is necessary to improve vaccine efficacy, because the vaccine antigen alone cannot induce sufficient protective immunity.
Teppei Matsuda, Kazuki Misato, Shigeyuki Tamiya, Yasuhiro Akeda, Ikuhiko Nakase, Etsushi Kuroda, Shokichi Takahama, Motohiro Nonaka, Takuya Yamamoto, Michiko N. Fukuda, Yasuo Yoshioka   +10 more
doaj   +1 more source

A molecular signature of lung-resident CD8+ T cells elicited by subunit vaccination

Scientific Reports, 2022
Natural infection as well as vaccination with live or attenuated viruses elicit tissue resident, CD8+ memory T cell (Trm) response. Trm cells so elicited act quickly upon reencounter with the priming agent to protect the host.
Naveenchandra Suryadevara, Amrendra Kumar, Xiang Ye, Meredith Rogers, John V. Williams, John T. Wilson, John Karijolich, Sebastian Joyce   +7 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Light‐Activated Isolation of High‐Quality Mitochondria for Therapeutic Transplantation

Angewandte Chemie, EarlyView.
The Light‐Activated Mitochondrial Isolation (LAMI) platform enables the selective and non‐destructive isolation of high‐purity, metabolically active mitochondria. By integrating modular, ligand‐programmable magnetic probes with photo‐cleavable release, LAMI overcomes long‐standing limitations of conventional isolation methods and provides a robust ...
Hui Liu, Yuxin Jiao, Ting Zhang, Haiwei Wang, Yufei Xue, Jiayu Ding, Yang Ding, Meiling Wang, Weisen Zhang, Hua Bai, Bo Peng, Nicolas H. Voelcker, Lin Li   +12 more
wiley   +2 more sources

Novel Immunoinformatics Approaches to Design Multi-epitope Subunit Vaccine for Malaria by Investigating Anopheles Salivary Protein

Scientific Reports, 2018
Malaria fever has been pervasive for quite a while in tropical developing regions causing high morbidity and mortality. The causal organism is a protozoan parasite of genus Plasmodium which spreads to the human host by the bite of hitherto infected ...
Rajan Kumar Pandey, Tarun Kumar Bhatt, Vijay Kumar Prajapati   +2 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Evaluation of Seasonal Inactivated Influenza Vaccines Prophylactic Efficacy

Эпидемиология и вакцинопрофилактика, 2022
Relevance. Seasonal flu vaccination is still the most effective way to protect against flu viruses and help to reduce the burden of flu illnesses. Another possible benefit is the impact of yearly vaccines on severity of breakthrough infection.
K. V. Zhdanov, K. Kasyanenko, O. V. Mal'cev, N. I. L'vov, D. A. Lioznov, I. I. Lapikov, K. S. Ivanov   +6 more
doaj   +1 more source