Results 1 to 10 of about 5,149,379 (301)

Reduced binding activity of vaccine serum to omicron receptor-binding domain

Frontiers in Immunology, 2022
Coronavirus disease 2019 (COVID-19) vaccination regimens contribute to limiting the spread of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2).
Mingzhi Li, Shiqi Weng, Quansheng Wang, Zibing Yang, Xiaoling Wang, Xiaoling Wang, Yanjun Yin, Qiuxiang Zhou, Lirong Zhang, Feifei Tao, Yihan Li, Mengle Jia, Lingdi Yang, Xiu Xin, Hanguang Li, Lumei Kang, Lumei Kang, Yu Wang, Ting Wang, Sha Li, Lingbao Kong   +20 more
doaj   +3 more sources

An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain

Cell Reports, 2020
Summary: IGHV3-53-encoded neutralizing antibodies are commonly elicited during SARS-CoV-2 infection and target the receptor-binding domain (RBD) of the spike (S) protein.
Nicholas C. Wu, Meng Yuan, Hejun Liu, Chang-Chun D. Lee, Xueyong Zhu, Sandhya Bangaru, Jonathan L. Torres, Tom G. Caniels, Philip J.M. Brouwer, Marit J. van Gils, Rogier W. Sanders, Andrew B. Ward, Ian A. Wilson   +12 more
doaj   +3 more sources

The Occluded Epitope Residing in Spike Receptor-Binding Motif Is Essential for Cross-Neutralization of SARS-CoV-2 Delta Variant

Current Issues in Molecular Biology, 2022
Concerns over vaccine efficacy after the emergence of the SARS-CoV-2 Delta variant prompted revisiting the vaccine design concepts. Monoclonal antibodies (mAbs) have been developed to identify the neutralizing epitopes on spike protein.
Weeraya Thongkum, Kanyarat Thongheang, Chatchai Tayapiwatana   +2 more
doaj   +1 more source

Identification of potential inhibitors of omicron variant of SARS-Cov-2 RBD based virtual screening, MD simulation, and DFT

Frontiers in Chemistry, 2022
Emergence of the SARS-CoV-2 Omicron variant of concern (VOC; B.1.1.529) resulted in a new peak of the COVID-19 pandemic, which called for development of effective therapeutics against the Omicron VOC.
Xudong Lü, Cuiyue Feng, Ruijie Lü, Xiyu Wei, Shuai Fan, Maocai Yan, Xiandui Zhu, Zhifei Zhang, Zhaoyong Yang   +8 more
doaj   +1 more source

Aromatic Residues on the Side Surface of Cry4Ba-Domain II of Bacillus thuringiensis subsp. israelensis Function in Binding to Their Counterpart Residues on the Aedes aegypti Alkaline Phosphatase Receptor

Toxins, 2023
Receptor binding is a prerequisite process to exert the mosquitocidal activity of the Cry4Ba toxin of Bacillus thuringiensis subsp. israelensis.
Anon Thammasittirong, Sutticha Na-Ranong Thammasittirong   +1 more
doaj   +1 more source

Epigallocatechin gallate (EGCG) attenuates severe acute respiratory coronavirus disease 2 (SARS-CoV-2) infection by blocking the interaction of SARS-CoV-2 spike protein receptor-binding domain to human angiotensin-converting enzyme 2.

PLoS ONE, 2022
The outbreak of the coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 triggered a global pandemic where control is needed through therapeutic and preventive interventions. This study aims to identify natural compounds
Tomokazu Ohishi, Takayuki Hishiki, Mirza S Baig, Sajjan Rajpoot, Uzma Saqib, Tomohiko Takasaki, Yukihiko Hara   +6 more
doaj   +3 more sources

Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors

Membranes, 2021
Kainate receptors are members of the ionotropic glutamate receptor family. They form cation-specific transmembrane channels upon binding glutamate that desensitize in the continued presence of agonists.
Cuauhtemoc U. Gonzalez, Elisa Carrillo, Vladimir Berka, Vasanthi Jayaraman   +3 more
doaj   +1 more source

Cry4Ba toxin of Bacillus thuringiensis subsp. israelensis uses both domains II and III to bind to its receptor—Aedes aegypti alkaline phosphatase

Heliyon, 2023
Receptor binding is one of the crucial steps to exhibit the insecticidal activity of Cry toxins. In addition, binding to receptors is a determining step for the specificity of toxins.
Anon Thammasittirong, Sutticha Na Ranong Thammasittirong   +1 more
doaj   +1 more source

Ex Vivo Immune Responsiveness to SARS-CoV-2 Omicron BA.5.1 Following Vaccination with Unmodified mRNA-Vaccine

Vaccines, 2023
(1) Background: The high incidence of SARS-CoV-2 infection in vaccinated persons underscores the importance of individualized re-vaccination. PanIg antibodies that act against the S1/-receptor binding domain quantified in serum by a routine diagnostic ...
Anna Sabrina Kuechler, Eva Heger, Maike Wirtz, Sandra Weinhold, Markus Uhrberg, Fritz Boege, Karin Schulze-Bosse   +6 more
doaj   +1 more source

OBTAINING AND CHARACTERIZATION OF RECOMBINANT FLUORESCENT DERIVATIVES OF SOLUBLE HUMAN HB-EGF [PDF]

Biotechnologia Acta, 2014
Heparin-binding EGF-like growth factor (HB-EGF) belongs to the epidermal growth factor receptor family and is synthesized as a transmembrane precursor proHB-EGF.
N. V. Korotkevich, A. Ju. Labyntsev, D. V. Kolibo, S. V. Komisarenko   +3 more
doaj   +1 more source