Results 31 to 40 of about 5,149,379 (301)

Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. [PDF]

, 2013
The tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine playing a key role in tissue regeneration and remodeling.
Jens Niewoehner, Monika Baehner, Kohnert, Ulrich, Schraeml, Michael, Ulrich Kohnert, Alfred Lammens, Katja Lammens, Lammens, Katja, Karl-Peter Hopfner, Leopold von Proff, Lammens, Alfred, Hopfner, Karl-Peter, Niewoehner, Jens, Michael Schraeml, Baehner, Monika, Proff, Leopold von, von Proff, Leopold (author), Hopfner Karl-Peter, Schraeml, Michael (author), Hopfner, Karl-Peter (author), Lammens, Katja (author), Schraeml Michael, Lammens Katja, Baehner Monika, Kohnert Ulrich, Lammens, Alfred (author), Niewoehner Jens, Baehner, Monika (author), Niewoehner, Jens (author), Kohnert, Ulrich (author), von Proff Leopold, Lammens Alfred   +31 more
core   +2 more sources

Application of the human estrogen receptor within a synthetic transcription factor in Trichoderma reesei

Fungal Biology and Biotechnology, 2020
Background Synthetic gene expression systems offer a possibility for controllable and targeted induction of the expression of genes of interest, which is a fundamental technique necessary for basic research and industrial applications. The human estrogen
Christian Derntl, Robert Mach, Astrid Mach-Aigner   +2 more
doaj   +1 more source

High resolution crystal structures of the receptor-binding domain of Clostridium botulinum neurotoxin serotypes A and FA [PDF]

PeerJ, 2018
The binding specificity of botulinum neurotoxins (BoNTs) is primarily a consequence of their ability to bind to multiple receptors at the same time. BoNTs consist of three distinct domains, a metalloprotease light chain (LC), a translocation domain (HN ...
Jonathan R. Davies, Gavin S. Hackett, Sai Man Liu, K. Ravi Acharya   +3 more
doaj   +2 more sources

Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses

Virology, 2011
Although H5N1 influenza viruses have been responsible for hundreds of human infections, these avian influenza viruses have not fully adapted to the human host. The lack of sustained transmission in humans may be due, in part, to their avian-like receptor preference. Here, we have introduced receptor binding domain mutations within the hemagglutinin (HA)
Maines, Taronna R., Chen, Li-Mei, Van Hoeven, Neal, Tumpey, Terrence M., Blixt, Ola, Belser, Jessica A., Gustin, Kortney M., Pearce, Melissa B., Pappas, Claudia, Stevens, James, Cox, Nancy J., Paulson, James C., Raman, Rahul, Sasisekharan, Ram, Katz, Jacqueline M., Donis, Ruben O.   +15 more
openaire   +4 more sources

Defining the Structure and Receptor Binding Domain of the Leaderless Bacteriocin LsbB [PDF]

Journal of Biological Chemistry, 2014
LsbB is a class II leaderless lactococcal bacteriocin of 30 amino acids. In the present work, the structure and function relationship of LsbB was assessed. Structure determination by NMR spectroscopy showed that LsbB has an N-terminal α-helix, whereas the C-terminal of the molecule remains unstructured.
Ovchinnikov, Kirill V., Kristiansen, Per E., Uzelac, Gordana, Topisirović, Ljubiša, Kojić, Milan, Nissen-Meyer, Jon, Nes, Ingolf F., Diep, Dzung B.   +7 more
openaire   +3 more sources

Loop B is a major structural component of the 5-HT3 receptor [PDF]

, 2008
The 5-HT3 receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence of six peptide loops (A-F).
Thompson, Andrew J., M. Lochner, Lummis, S. C. R., Lummis, S.C.R., S. C. R. Lummis, A. J. Thompson, Lochner, Martin, Thompson, Andrew James   +7 more
core   +2 more sources

Identification of a Receptor-Binding Domain of Bordetella Dermonecrotic Toxin [PDF]

Infection and Immunity, 2002
ABSTRACT Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibers and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin which is composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain.
Takeshi, Matsuzawa, Takashige, Kashimoto, Jun, Katahira, Yasuhiko, Horiguchi   +3 more
openaire   +2 more sources

Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

Nature Communications, 2020
Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding domain (RBD) proteins, the authors identify a number of single domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the ...
Xiaojing Chi, Xiuying Liu, Conghui Wang, Xinhui Zhang, Xiang Li, Jianhua Hou, Lili Ren, Qi Jin, Jianwei Wang, Wei Yang   +9 more
doaj   +1 more source

A Pathway Model to Understand the Evolution of Spike Protein Binding to ACE2 in SARS-CoV-2 Variants

Biomolecules, 2022
After the SARS-CoV-2 Wuhan variant that gave rise to the pandemic, other variants named Delta, Omicron, and Omicron-2 sequentially became prevalent, with mutations spread around the viral genome, including on the spike (S) protein; in order to understand
Ludovico Pipitò, Christopher A. Reynolds, Juan Carlos Mobarec, Owen Vickery, Giuseppe Deganutti   +4 more
doaj   +1 more source

The Receptor-Binding Domain in the VP1u Region of Parvovirus B19

Viruses, 2016
Parvovirus B19 (B19V) is known as the human pathogen causing the mild childhood disease erythema infectiosum. B19V shows an extraordinary narrow tissue tropism for erythroid progenitor cells in the bone marrow, which is determined by a highly restricted uptake. We have previously shown that the specific internalization is mediated by the interaction of
Leisi, Gian Remo, Di Tommaso, Chiarina, Kempf, Christoph, Ros Bascunana, Carlos   +3 more
openaire   +4 more sources