Results 41 to 50 of about 5,149,379 (301)

Heterologous sarbecovirus receptor binding domains as scaffolds for SARS-CoV-2 receptor binding motif presentation

, 2023
Abstract Structure-guided rational immunogen design can generate optimized immunogens that elicit a desired humoral response. Design strategies often center upon targeting conserved sites on viral glycoproteins that will ultimately confer potent neutralization.
Blake M. Hauser, Maya Sangesland, Evan C. Lam, Kerri J. St. Denis, Maegan L. Sheehan, Mya L. Vu, Agnes H. Cheng, Alejandro B. Balazs, Daniel Lingwood, Aaron G. Schmidt   +9 more
openaire   +2 more sources

Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]

, 2013
Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core   +1 more source

Unconventional structure and mechanisms for membrane interaction and translocation of the NF-κB-targeting toxin AIP56

Nature Communications, 2023
Bacterial AB toxins are secreted key virulence factors that are internalized by target cells through receptor-mediated endocytosis, translocating their enzymatic domain to the cytosol from endosomes (short-trip) or the endoplasmic reticulum (long-trip ...
Johnny Lisboa, Cassilda Pereira, Rute D. Pinto, Inês S. Rodrigues, Liliana M. G. Pereira, Bruno Pinheiro, Pedro Oliveira, Pedro José Barbosa Pereira, Jorge E. Azevedo, Dominique Durand, Roland Benz, Ana do Vale, Nuno M. S. dos Santos   +12 more
doaj   +1 more source

Calcium induces a conformational change in the ligand binding domain of the low density lipoprotein receptor

Journal of Lipid Research, 1998
We previously have shown that LDL-R354, a truncated low density lipoprotein (LDL) receptor, is a calcium binding protein. LDL-R354 is composed of the ligand binding domain and repeat A of the EGF precursor homology domain of the full-length human LDL ...
Kimberly A. Dirlam-Schatz, Alan D. Attie
doaj   +1 more source

Omicron variant receptor-binding domain phylogenetics and molecular dynamics

Computers in Biology and Medicine, 2022
Investigamos las relaciones evolutivas, las mutaciones, los epítopos antigénicos y la dinámica estructural del dominio de unión al receptor (RBD) del SARS-CoV-2, Omicron y otras variantes evolucionadas recientemente. El RBD del SARS-CoV-2 y sus variantes Omicron, Alpha, Beta, Gamma, Delta y Mu se sometieron a una evaluación de la matriz de secuencia ...
Mahmoud Kandeel, Wael El‐Deeb
openaire   +3 more sources

Receptor-binding domain of murine leukemia virus envelope glycoproteins [PDF]

Journal of Virology, 1995
The surface glycoprotein (SU) of murine leukemia viruses (MuLVs) comprises two domains connected by a proline-rich hinge. The interaction of MuLV particles with subgroup-specific cell surface receptors depends primarily on two variable regions (VRA and VRB) located in the amino-terminal domain.
J L, Battini, O, Danos, J M, Heard
openaire   +2 more sources

Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.

PLoS ONE, 2014
The steroid hormone receptors regulate important physiological functions such as reproduction, metabolism, immunity, and electrolyte balance. Mutations within steroid receptors result in endocrine disorders and can often drive cancer formation and ...
William H Hudson, Christine Youn, Eric A Ortlund   +2 more
doaj   +1 more source

The Rat Asialoglycoprotein Receptor Binds the Amino-Terminal Domain of Thyroglobulin

Biochemical and Biophysical Research Communications, 2000
We have previously reported that the rat hepatic lectin-1 (RHL-1) subunit of rat asialoglycoprotein receptor (ASGPr), the endocytic receptor found on the basolateral surface of hepatocytes, was expressed in rat thyroid tissue and localized on the apical surface of polarized rat thyroid FRT cells.
MONTUORI, NUNZIA, Pacifico F., Mellone S, Liguoro D., Di Jeso B., FORMISANO, SILVESTRO, Gentile F., CONSIGLIO, EDUARDO   +7 more
openaire   +6 more sources

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

iScience, 2022
Summary: The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease.
Phillip Pymm, Samuel J. Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P. Cooney, Kathryn C. Davidson, Ebene R. Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L. Grimley, Damian F.J. Purcell, Stephen J. Kent, Adam K. Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W. Chung, Kanta Subbarao, Adam P. Uldrich, Wai-Hong Tham, Dale I. Godfrey, Nicholas A. Gherardin   +23 more
doaj   +1 more source

Inhibition of lipoprotein lipase by the receptor‐binding domain of apolipoprotein E

FEBS Letters, 1989
A synthetic peptide (residues 139–153) corresponding to the receptor‐binding domain of apolipoprotein E (ApoE) was tested for lipoprotein lipase (LPL) inhibitory properties. In systems using both natural and synthetic substrates, inhibition of LPL was observed.
McConathy, Walter.J., Wang, Chi-Sun
openaire   +2 more sources