Results 61 to 70 of about 5,149,379 (301)
Journal of Pharmacological Sciences, 2011 .: The purpose of this study is to identify transient receptor potential canonical (TRPC) channels responsible for receptor-operated Ca2+ entry (ROCE) triggered by activation of endothelin type A receptor (ETAR) and to clarify the importance of ...
Takahiro Horinouchi +6 more
doaj +1 more source
The Biologist’s Guide to the Glucocorticoid Receptor’s Structure
Cells, 2023 The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor.
Nick Deploey +4 more
doaj +1 more source
Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain
, 2003 The ligand-binding domains of AMPA receptor subunits carry two conserved N-glycosylation sites. In order to gain insight into the functional role of the corresponding N-glycans, we examined how the elimination of glycosylation at these sites (N407 and ...
Sarah K. Coleman +7 more
core +1 more source
Frontiers in Ecology and Evolution, 2021 It remains a mystery why estrogen hormone receptors (ERs), which are highly specific toward its endogenous hormones, are responsive to chemically distinct exogenous agents. Does it indicate that ERs are environmentally regulated?
Divya Lakshmanan Mangalath +2 more
doaj +1 more source
High-resolution crystal structure of human coronavirus HKU1 receptor binding domain bound to TMPRSS2 receptor [PDF]
hLifeWei Wang +7 more
doaj +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Engineered receptor binding domain immunogens elicit pan-sarbecovirus neutralizing antibodies outside the receptor binding motif [PDF]
, 2020 Abstract Effective countermeasures are needed against emerging coronaviruses of pandemic potential, similar to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Designing immunogens that elicit broadly neutralizing antibodies to conserved viral epitopes on the major surface glycoprotein, spike, such as the receptor binding ...
Blake M. Hauser +10 more
openaire +2 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248 [PDF]
, 2003 The transcription factor C/EBPa regulates early steps of normal granulocyte differentiation since mice with a disruption of the C/EBPa gene do not express detectable levels of the G-CSF receptor and produce no neutrophils.
Singh, Sheo Mohan
core +1 more source
Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor. [PDF]
PLoS ONE, 2017 γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, and disturbances in the GABAergic system have been implicated in numerous neurological and neuropsychiatric diseases.
Thibaud Freyd +5 more
doaj +1 more source