Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure [PDF]
, 2010 The mineralocorticoid receptor (MR) binds the steroid hormones aldosterone and cortisol and has an important physiological role in the control of salt homeostasis.
Fischer, Katharina +14 more
core +1 more source
Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction. [PDF]
, 2022 BACKGROUND Several new variants of SARS-CoV-2 have emerged since fall 2020 which have multiple mutations in the receptor-binding domain (RBD) of the spike protein.
Chang, Xinyue +13 more
core +2 more sources
Viruses, 2016 Porcine epidemic diarrhea virus (PEDV), a member of Alphacoronavirus, has caused huge economic losses for the global pork industry recently. The spike (S) protein mediates PEDV entry into host cells. Herein, we investigated the interactions between the S
Feng Deng +10 more
doaj +1 more source
Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain. [PDF]
PLoS ONE, 2014 Activation of the glucagon-like peptide-1 receptor (GLP-1R) in pancreatic β-cells potentiates insulin production and is a current therapeutic target for the treatment of type 2 diabetes mellitus (T2DM).
Graham M West +5 more
doaj +1 more source
Binding of alpha-ACTN4 to EGF receptor enables its rapid phosphorylation
Heliyon, 2021 Alpha-ACTN4, a member of alpha-actinin family is critical for cell motility through its regulated binding of actin filaments. We previously found that EGF exposure of cells triggers the tyrosyl-phosphorylation of ACTN4 in fibroblasts that dramatically ...
Hanshuang Shao, Alan Wells
doaj +1 more source
p160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain [PDF]
, 2008 Transcriptional activation involves the ordered recruitment of coactivators via direct interactions between distinct binding domains and recognition motifs.
Coudevylle, N. +12 more
core +1 more source
Characterization of the receptor-binding domain of tetanus toxin
Journal of Biological Chemistry, 1993 The carboxyl-terminal half of the heavy chain of tetanus toxin (Hc) contains the domain required for binding to purified gangliosides and neuronal cells. The structural requirements for the interaction of Hc with receptor were studied by generating mutants of Hc with deletions at either the carboxyl or amino terminus and characterizing their binding. A
J L, Halpern, A, Loftus
openaire +2 more sources
Aerolysin and pertussis toxin share a common receptor‐binding domain [PDF]
The EMBO Journal, 1997 We have discovered that the bacterial toxins aerolysin and pertussis toxin share a common domain. This is surprising because the two toxins affect cells in very different ways. The common domain, which we call the APT domain, consists of two three-stranded antiparallel beta-sheets that come together and wrap around a central pair of helices.
J, Rossjohn +5 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2023 Glycine receptor (GlyR) autoantibodies are associated with stiff-person syndrome and the life-threatening progressive encephalomyelitis with rigidity and myoclonus in children and adults.
Vera Rauschenberger +13 more
doaj +1 more source
Definition of the Interferon-α Receptor-binding Domain on the TYK2 Kinase [PDF]
Journal of Biological Chemistry, 1998 Interferons and cytokines modulate gene expression via a simple, direct signaling pathway containing receptors, JAK tyrosine kinases, and STAT transcription factors. The interferon-alpha pathway is a model for these cascades. Two receptors, IFNaR1 and IFNaR2, associate exclusively in a constitutive manner with two JAK proteins, TYK2 and JAK1 ...
H, Yan +4 more
openaire +2 more sources