Results 11 to 20 of about 5,149,379 (301)

Receptor-binding domain-associated serotypes of SARS-CoV-2 [PDF]

Emerging Microbes and Infections
Zezhong Liu, Lu Lu, Shibo Jiang
doaj   +4 more sources

Engineered Human Monoclonal scFv to Receptor Binding Domain of Ebolavirus [PDF]

Vaccines, 2021
(1) Background: Ebolavirus (EBOV) poses as a significant threat for human health by frequently causing epidemics of the highly contagious Ebola virus disease (EVD).
Jaslan Densumite, Siratcha Phanthong, Watee Seesuay, Nitat Sookrung, Urai Chaisri, Wanpen Chaicumpa   +5 more
doaj   +3 more sources

Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. [PDF]

PLoS ONE, 2012
Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Ana Tomasovic, Stephanie Traub, Ritva Tikkanen   +2 more
doaj   +3 more sources

Multistep receptor binding of the hepatitis B virus preS1 domain

Nature Communications
The preS1 domain present on hepatitis B and D virus particles is an intrinsically disordered peptide (IDP) essential for recognizing the host receptor, sodium taurocholate co-transporting polypeptide (NTCP).
Chisa Kobayashi, Toru Ekimoto, Koji Ooka, Junki Mifune, Kayo Matsuzawa, Lusheng Que, Yingfang Li, Atsuto Kusunoki, Takeshi Morita, Kaho Shionoya, Makoto Nagano, Kousho Wakae, Masanori Isogawa, Masamichi Muramatsu, Umeharu Ohto, Norimichi Nomura, Sam-Yong Park, Camille Sureau, Munehito Arai, Mitsunori Ikeguchi, Koichi Watashi   +20 more
doaj   +3 more sources

The antigenic anatomy of SARS-CoV-2 receptor binding domain [PDF]

Cell, 2020
Resumen Los anticuerpos son cruciales para la protección inmunitaria contra el SARS-CoV-2, con algunos en uso de emergencia como agentes terapéuticos. Aquí, identificamos 377 anticuerpos monoclonales humanos (mAb) que reconocen el pico del virus y nos centramos principalmente en 80 que se unen al dominio de unión al receptor (RBD).
Wanwisa Dejnirattisai, Daming Zhou, Helen M. Ginn, Helen M. E. Duyvesteyn, Piyada Supasa, William James, Yuguang Zhao, Thomas S. Walter, Alexander J. Mentzer, Chang Liu, Beibei Wang, Guido C. Paesen, Jose Luis Slon-Campos, César López‐Camacho, Natasha M. Kafai, Adam L. Bailey, Rita E. Chen, Baoling Ying, Craig Thompson, Jai S. Bolton, Alex Fyfe, Sunetra Gupta, Tiong Kit Tan, Javier Gilbert‐Jaramillo, William James, Michael L. Knight, Miles W. Carroll, Donal Skelly, Christina Dold, Yanchun Peng, Robert H. Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Paul Klenerman, Nigel Temperton, David R. Hall, Mark A. Williams, Neil G. Paterson, F.K.R. Bertram, C. Alistair Siebert, Daniel K. Clare, Andrew Howe, Julika Radecke, Yun Song, Alain Townsend, Kuan-Ying A. Huang, Elizabeth E. Fry, Juthathip Mongkolsapaya, Michael Diamond, Jingshan Ren, D.I. Stuart, Gavin Screaton   +52 more
openaire   +7 more sources

The binding and activation of the glucagon-like peptide-1 receptor by exendin-4 [PDF]

, 2010
Background and purpose Exendin-4 (EX4) has the same physiological properties as glucagon-like peptide-1 (7-36)amide (GLP-1). EX4 has 50% identity with GLP-1, with an extra nine amino acids at its C-terminus.
Nasr, Elsayed Mohammed Nasr
core   +4 more sources

Computer modelling of the receptor-binding domains of VEGF and PIGF [PDF]

Protein Engineering Design and Selection, 1997
Models of the platelet-derived growth factor (PDGF)-like domains of vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) were built based on their homology to PDGF. These domains contain most of the determinants for receptor binding.
T P, Walsh, G H, Grant
openaire   +2 more sources

Receptor Binding Domain Based HIV Vaccines

BioMed Research International, 2015
This paper analyzes the main trend of the development of acquired immunodeficiency syndrome (AIDS) vaccines in recent years. Designing an HIV-1 vaccine that provides robust protection from HIV-1 infection remains a challenge despite many years of effort.
Liu, Huan, Bi, Wenwen, Wang, Qian, Lu, Lu, Jiang, Shibo   +4 more
openaire   +3 more sources

Crystal structure of the receptor-binding domain of α2-macroglobulin [PDF]

Structure, 1998
The large plasma proteinase inhibitors of the alpha 2-macroglobulin superfamily inhibit proteinases by capturing them within a central cavity of the inhibitor molecule. After reaction with the proteinase, the alpha-macroglobulin-proteinase complex binds to the alpha-macroglobulin receptor, present in the liver and other tissues, and becomes endocytosed
Jenner, L, Husted, L, Thirup, S, Sottrup-Jensen, L, Nyborg, J   +4 more
openaire   +3 more sources

Bacillus thuringiensis Cry4Ba Insecticidal ToxinExploits Leu⁶¹⁵ in Its C-Terminal Domain to Interact with a Target Receptor—Aedes aegypti Membrane-Bound Alkaline Phosphatase

Toxins, 2021
In addition to the receptor-binding domain (DII), the C-terminal domain (DIII) of three-domain Cry insecticidal δ-endotoxins from Bacillus thuringiensis has been implicated in target insect specificity, yet its precise mechanistic role remains unclear ...
Anon Thammasittirong, Sutticha Na-Ranong Thammasittirong, Chompounoot Imtong, Sathapat Charoenjotivadhanakul, Somsri Sakdee, Hui-Chun Li, Siriporn Okonogi, Chanan Angsuthanasombat   +7 more
doaj   +1 more source