Results 201 to 210 of about 20,257 (224)

Relationship of NEFA concentrations to RBP4 and to RBP4/retinol in prepubertal children with and without obesity

Journal of Clinical Lipidology, 2019
The regulation of adipose tissue metabolism in early childhood obesity is not well understood. Insulin levels are higher and insulin resistance seems to be present in prepubertal children with obesity but, differing from their behavior in adults with obesity, non-esterified fatty acid (NEFA) concentrations are not increased.
Henar Ortega-Senovilla, Manuel de Oya, Carmen Garcés   +2 more
openaire   +2 more sources

Effect of RBP4 gene variants on circulating RBP4 concentration and Type 2 diabetes in a Chinese population

Diabetic Medicine, 2008
AbstractAims  Retinol binding protein 4 (RBP4) is a newly discovered adipokine, which plays a role in insulin resistance and obesity. The aim of this study was to determine the relationship between genetic variants of the RBP4 gene, circulating RBP4 concentrations and phenotypes related to glucose and lipid metabolism in the Chinese population.Methods  
C, Hu, W, Jia, R, Zhang, C, Wang, J, Lu, H, Wu, Q, Fang, X, Ma, K, Xiang   +8 more
openaire   +2 more sources

Serum RBP4 and CKD: Association with insulin resistance and lipids

Journal of Diabetes and its Complications, 2017
Serum RBP4 is new adipokine and it has been related to insulin resistance and diabetes risk in animal and clinical studies. However, there is controversy on this relationship among CKD patients. In this study, we evaluated the association of serum RBP4 with insulin resistance and cardiovascular risk factors in CKD.Baseline data from the PROGREDIR Study
Maria Alice M, Domingos, Márcia, Queiroz, Paulo Andrade, Lotufo, Isabela Judith, Benseñor, Silvia Maria de Oliveira, Titan   +4 more
openaire   +2 more sources

Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation

Endocrine, 2014
Retinol-binding protein 4 (RBP4) is a newly discovered adipocytokine related to insulin resistance (IR). Hyperinsulinemia and IR are the major risk factors for cardiovascular diseases (CVD). The role of RBP4 in CVD has not yet been determined. The present study was designed to analyze the correlation of RBP4 and CVD risk factors and to evaluate the ...
Fei, Li, Ke, Xia, Sayed Ali, Sheikh, Jinfang, Cheng, Chuanchang, Li, Tianlun, Yang   +5 more
openaire   +2 more sources

Identification of RBP4 from bighead carp (Hypophthalmichthys nobilis) / silver carp (Hypophthalmichthys molitrix) and effects of CpG ODN on RBP4 expression under A. hydrophila challenge

Fish & Shellfish Immunology, 2020
Retinol-binding protein 4 (RBP4) is known as a highly conserved adipokine for immune activation. Aeromonas hydrophila (A. hydrophila) is the most common zoonotic pathogen in aquaculture, which causes serious economic losses to aquaculture, especially to bighead carp (Hypophthalmichthys nobilis, H.
Jiaoqing, Li, Qin, Fan, Haiming, Cai, Jinbo, Deng, Feiping, Ming, Jiayi, Li, Min, Zeng, Miaopeng, Ma, Peijing, Zhao, Qianyi, Liang, Junhao, Jia, Shuxia, Zhang, Linghua, Zhang   +12 more
openaire   +2 more sources

Association of RBP4 gene variants with adverse lipid profile and obesity

Gene, 2015
Obesity is currently a worldwide public health problem. Retinol-binding protein4 (RBP4) is a recently discovered adipokine, which is potentially associated with insulin resistance and obesity. We aimed to investigate whether genetic variation within the RBP4 gene is correlated with the obesity and lipid profile in Iranian population.
Mansour, Shajarian, Laleh, Rafiee, Hajar, Naji-Esfahani, Shaghayegh, Haghjooy-Javanmard, Sarrafzadegan, Nizal   +4 more
openaire   +2 more sources

A novel homozygous c.67C>T variant in retinol binding protein 4 (RBP4) associated with retinitis pigmentosa and childhood acne vulgaris

Ophthalmic Genetics, 2020
Background The retinol binding protein 4 (RBP4) is essential in delivering retinol to the retinal pigment epithelium and normal functioning of the visual cycle.
J. Cehajic-Kapetanovic, K. Jasani, M. Shanks, P. Clouston, R. MacLaren   +4 more
semanticscholar   +1 more source

Increased retinol-free RBP4 contributes to insulin resistance in gestational diabetes mellitus

Archives of Gynecology and Obstetrics, 2017
Retinol-binding protein 4 (RBP4) is a circulating retinol transporter that is strongly associated with insulin resistance. The aim of this study was to evaluate the RBP4 and retinol level in rat model of gestational diabetes mellitus and the relationship between retinol-free RBP4 (apo-RBP4), retinol-bound RBP4 (holo-RBP4) and insulin resistance ...
Yanmin, Chen, Ping, Lv, Mengkai, Du, Zhaoxia, Liang, Menglin, Zhou, Danqing, Chen   +5 more
openaire   +2 more sources

Targeting Retinol-Binding Protein 4 (RBP4) in the Management of Cardiometabolic Diseases

Cardiovascular Toxicology, 2023
Cecilia Oluwamodupe, Adesola Oluwaseun Adeleye   +1 more
semanticscholar   +1 more source

RBP4 functions as an antagonistic ligand of orphan DR6

SummaryDeath receptor (DR) is a unique transmembrane receptor mediating extrinsic factor-induced programmed cell death pathways. For most DRs, the regulatory mechanism has been revealed to involve agonistic death ligand (e.g., TRAIL, TNF-α)-driven receptor clustering and activation, offering an in-depth understanding of the mechanistic basis for cell ...
Taeyun Kim, Wonhee John Lee, Thy N. C. Nguyen, Juhee Jang, Kiwook Kim, Min-Sik Kim, Daeha Seo, Young-Sam Lee, Yun-Il Lee   +8 more
openaire   +1 more source