Results 31 to 40 of about 236,804 (100)

Case Report: Complete response to pembrolizumab monotherapy in a geriatric patient with metastatic Merkel cell carcinoma and TNBC

Frontiers in Oncology
We present a case of a 98-year-old patient with metastatic Merkel cell carcinoma (MCC), a rare and aggressive neuroendocrine skin cancer, and locally advanced triple-negative breast cancer (TNBC), who achieved durable remission of both diseases with anti-
Jessica Liu, Kelly Olino, Maryam Lustberg, Maryam Lustberg, Jane Kanowitz   +4 more
doaj   +1 more source

Where does ISAC (immune-stimulating antibody conjugates) go from here?

Journal for ImmunoTherapy of Cancer
Immune-stimulating antibody conjugates (ISACs) have emerged as a promising class of therapeutics, employing design principles similar to antibody-drug conjugates (ADCs) but replacing cytotoxic payloads with immune-stimulatory agents. These agents enhance
Chen Fu
doaj   +1 more source

Constructing a pancancer ubiquitination regulatory network to determine tumor characteristics, immunotherapy response, and prognosis

Journal for ImmunoTherapy of Cancer
Background Ubiquitination—a pivotal post-translational modification that orchestrates cellular homeostasis and oncogenic pathways—remains underexplored as a pancancer regulatory hub. Although ubiquitination dysregulation is linked to tumor progression, a
Jie He, Peng Wu, Nan Sun, Zheng Zhou, Bing-zhi Wang, Xin Dong, Chaoqi Zhang, Guochao Zhang   +7 more
doaj   +1 more source

Low fT3/fT4 ratio as a proxy for muscle wasting in patients with advanced non-small cell lung cancer treated with pembrolizumab

Frontiers in Oncology
BackgroundLoss of skeletal muscle mass may serve as a valuable indicator of treatment efficacy and survival in individuals with lung cancer undergoing immunotherapy. This investigation sought to pinpoint accessible markers that could reflect the presence
Serena Eccher, Marco Sposito, Ilaria Trestini, Ilaria Mariangela Scaglione, Luca Pasqualin, Daniela Tregnago, Alice Avancini, Alice Avancini, Jessica Insolda, Linda Confortini, Alessandra Dodi, Alessio Stefani, Marco Cintoni, Isabella Sperduti, Maria Cristina Mele, Fotios Loupakis, Marcello Tiseo, Emilio Bria, Emilio Bria, Michele Milella, Sara Pilotto, Lorenzo Belluomini   +21 more
doaj   +1 more source

Microstructure and Hardness Evolution in Haynes 282 Nickel-Based Superalloy During Multi-variant Aging Heat Treatment

Journal of materials engineering and performance (Print), 2019
In this paper, the effect of applied multi-variant heat treatment on microstructure, phase composition and mechanical response of Haynes 282 nickel-based superalloy was investigated.
A. Polkowska, W. Polkowski, M. Warmuzek, Natalia Cieśla, G. Włoch, D. Zasada, R. Purgert   +6 more
semanticscholar   +1 more source

Precipitation of γ’ during cooling of nickel-base superalloy Haynes 282

Philosophical Magazine Letters, 2020
Cooling-induced precipitation of the strengthening γ’ phase is commonly investigated in Ni-base superalloys with a high γ’ volume fraction, where it is used to control the final microstructure and properties.
C. Joseph, M. Thuvander, C. Persson, Magnus Hörnqvist Colliander   +3 more
semanticscholar   +1 more source

Characteristics of cancer susceptibility genes mutations in 282 patients with gastric adenocarcinoma

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2020
Objective To reveal the distribution signature of cancer susceptibility genes in patients with gastric adenocarcinoma, offering a diagnostic and prognostic surrogate for disease risk management and therapeutic decisions.
K. Ji, Sheng Ao, Liu He, Lijiao Zhang, Li Feng, G. Lyu   +5 more
semanticscholar   +1 more source

Seronegative Paraneoplastic Opsoclonus–Myoclonus–Ataxia Syndrome Secondary to Low Volume Endocrine-Sensitive Malignancy of Likely Breast Origin

Current Oncology
A 51-year-old female presented to the emergency department with vertigo, visual disturbances, involuntary rapid repetitive eye movements, incoordination, and imbalance.
Geraint Berger, Caitlin Jackson-Tarlton, Daniel Rayson, Alexander Silver, Mark Walsh, Ashley Drohan   +5 more
doaj   +1 more source

New Trends in Thyroid Malignancy: Minimally Invasive Thermal Ablation Percutaneous Techniques for T1 Papillary Thyroid Carcinomas

Current Oncology
During the late 1990s, thyroid nodule management strongly improved with the development of high-frequency ultrasound (HFUS) and US-guided percutaneous procedures [...]
Pierre Yves Marcy
doaj   +1 more source

Comprehensive Genomic Profiling of 282 Pediatric Low‐ and High‐Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures

The Oncologist, 2017
This study highlights the value of comprehensive genomic profiling in the largest known cohort of pediatric glioma patients and explores the most common alterations across diagnosis and anatomic location.
Adrienne Johnson, E. Severson, L. Gay, J. Vergilio, J. Elvin, J. Suh, S. Daniel, Mandy Covert, G. Frampton, S. Hsu, G. Lesser, Kimberly Stogner‐Underwood, R. Mott, S. Rush, Jennifer J. Stanke, S. Dahiya, James X. Sun, P. Reddy, Z. Chalmers, R. Erlich, Yakov Chudnovsky, D. Fabrizio, A. Schrock, Siraj M. Ali, V. Miller, P. Stephens, J. Ross, J. Crawford, S. Ramkissoon   +28 more
semanticscholar   +1 more source