Results 31 to 40 of about 178,030 (50)

Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming

Frontiers in Oncology, 2022
BackgroundThymidine kinase 1 (TK1) is a cell cycle-dependent kinase that catalyzes the addition of a gamma-phosphate group to thymidine. The protumorigenic role of TK1 has been reported in various malignancies.
Sipeng Zuo, Sipeng Zuo, Huixue Wang, Huixue Wang, Lin Li, Lin Li, Hui Pan, Hui Pan, Linna Lu, Linna Lu   +9 more
doaj   +1 more source

B7H6 Serves as a Negative Prognostic Marker and an Immune Modulator in Human Pancreatic Cancer

Frontiers in Oncology, 2022
Pancreatic cancer (PC), the third leading cause of cancer-related death in the U.S., is frequently found too late to be cured by traditional chemotherapy.
Zheng Zhu, Zheng Zhu, Zheng Zhu, Zheng Zhu, Zheng Zhu, Kun-Yu Teng, Jian Zhou, Yunyun Xu, Lifeng Zhang, Hua Zhao, Xueguang Zhang, Xueguang Zhang, Xueguang Zhang, Lei Tian, Zhiyao Li, Ting Lu, Shoubao Ma, Zhenlong Li, Zhenyu Dai, Jing Wang, Xingyu Chen, Xing Wu, Yihan Pan, Weiqiang Shi, Zhiqun You, Hanyu Chen, Vincent Chung, Jianhua Yu, Songbing He, Xin Zhao, Lei Cao, Lei Cao, Lei Cao, Dechun Li   +33 more
doaj   +1 more source

Comprehensive Genomic Profiling for Therapeutic Decision and Identification of Gene Mutation in Uterine Endometrial Dedifferentiated Carcinoma

Case Reports in Oncology, 2022
Endometrial dedifferentiated carcinoma is a new concept among endometrial malignancies, is rare, and has a poor prognosis as it is discovered in advanced stages and has no established treatment.
Yusuke Taira, Yuko Shimoji, Yoshihisa Arakaki, Tomoko Nakamoto, Wataru Kudaka, Yoichi Aoki   +5 more
doaj   +1 more source

A Case Report of Post-Radiotherapy c-MYC-Positive Angiosarcoma of the Breast

Case Reports in Oncology, 2022
Angiosarcoma of the breast is an unusual malignancy and carries a poor prognosis, with a 5-year overall survival rate ranging from 27 to 48%. Radiotherapy-induced angiosarcoma (RIAS) of the breast is very uncommon, with an estimated incidence of 1 in 1 ...
Edna Retter, Carol-Ann Benn, Christopher Maske, Bernardo Leon Rapoport   +3 more
doaj   +1 more source

AXL and MET in Hepatocellular Carcinoma: A Systematic Literature Review

Liver Cancer, 2022
Background: Multikinase inhibitors (MKIs) have been shown to improve survival in patients with hepatocellular carcinoma (HCC) compared with placebo. Distinct from other MKIs, cabozantinib has inhibitory activity for both AXL and MET.
Chih-Hung Hsu, Yi-Hsiang Huang, Shi-Ming Lin, Chiun Hsu   +3 more
doaj   +1 more source

White Matter Tracts and Diffuse Lower-Grade Gliomas: The Pivotal Role of Myelin Plasticity in the Tumor Pathogenesis, Infiltration Patterns, Functional Consequences and Therapeutic Management

Frontiers in Oncology, 2022
For many decades, interactions between diffuse lower-grade glioma (LGG) and brain connectome were neglected. However, the neoplasm progression is intimately linked to its environment, especially the white matter (WM) tracts and their myelin status. First,
Hugues Duffau, Hugues Duffau
doaj   +1 more source

Myasthenia Gravis Mimicking Third Cranial Nerve Palsy: a Case Report

Journal of Cancer and Allied Specialties, 2021
Background: The most common pituitary adenoma presentation is a visual field defect and inappropriate pituitary hormone secretion. The compression of the optic chiasma causes visual impairment.
Sardar Ali Khan, Waqas Shafiq, Umal Azmat, Ahmed Imran Siddiqi, Waqas Ahmad   +4 more
doaj   +1 more source

Data analytics and artificial intelligence in predicting length of stay, readmission, and mortality: a population-based study of surgical management of colorectal cancer

Discover Oncology, 2022
Data analytics and artificial intelligence (AI) have been used to predict patient outcomes after colorectal cancer surgery. A prospectively maintained colorectal cancer database was used, covering 4336 patients who underwent colorectal cancer surgery ...
Shamsul Masum, Adrian Hopgood, Samuel Stefan, Karen Flashman, Jim Khan   +4 more
doaj   +1 more source

An exploration of immunohistochemistry-based prognostic markers in patients undergoing curative resections for colon cancer

BMC Cancer, 2022
Background The immune system recognizes and destroys cancer cells. However, cancer cells develop mechanisms to avoid detection by expressing cell surface proteins. Specific tumour cell surface proteins (e.g.
Astrid Louise Bjørn Bennedsen, Luyi Cai, Rune Petring Hasselager, Aysun Avci Özcan, Khadra Bashir Mohamed, Jens Ole Eriksen, Susanne Eiholm, Michael Bzorek, Anne-Marie Kanstrup Fiehn, Thomas Vauvert F. Hviid, Ismail Gögenur   +10 more
doaj   +1 more source

Checkpoint inhibitors in metastatic gastric and GEJ cancer: a multi-institutional retrospective analysis of real-world data in a Western cohort

BMC Cancer, 2022
Background Safety and efficacy of immune checkpoint inhibitors in advanced gastric or gastroesophageal junction (GEJ) cancer could be demonstrated in predominantly Asian cohorts, whereas data in Western patients outside of clinical trials are vastly ...
Verena Schlintl, Florian Huemer, Gabriel Rinnerthaler, Thomas Melchardt, Thomas Winder, Patrick Reimann, Jakob Riedl, Arno Amann, Wolfgang Eisterer, Franz Romeder, Gudrun Piringer, Aysegül Ilhan-Mutlu, Ewald Wöll, Richard Greil, Lukas Weiss   +14 more
doaj   +1 more source