Results 51 to 60 of about 236,804 (100)

Management and outcomes of non–small cell lung cancer patients with rapid progression under second‐or‐more‐line immune checkpoint inhibitors: ERORECI study (GFPC 2016‐04)

Cancer Medicine, 2020
Background Immune checkpoint inhibitors (ICIs) have been approved as second‐line therapy for advanced non–small cell lung cancers (NSCLCs) progressing after platinum‐based chemotherapy.
Alain Vergnenegre, Margaux Geier, Florian Guisier, Regine Lamy, Bénédicte Comet, Gwenaelle Le Garff, Pascal Do, Henri Janicot, Hugues Morel, Chantal Decroisette, Michel Andre, Lionel Falchero, Nicolas Paleiron, Isabelle Monnet, the GFPC Team   +14 more
doaj   +1 more source

Small-Molecule Drugs in Pediatric Neuro-Oncology

Current Oncology
Advances in molecular diagnostics have enabled precision medicine approaches in pediatric neuro-oncology, with small-molecule drugs emerging as promising therapeutic candidates targeting specific genetic and epigenetic alterations in central nervous ...
Stephanie Vairy, George Michaiel
doaj   +1 more source

Reduced PLCG1 expression is associated with inferior survival for myelodysplastic syndromes

Cancer Medicine, 2020
The PLCG1 gene, which encodes the phospholipase C γ1 isoform, is located within the commonly deleted region of the long arm of chromosome 20 (del(20q)) observed in myelodysplastic syndromes (MDS).
Masayuki Shiseki, Mayuko Ishii, Mari Miyazaki, Satoko Osanai, Yan‐Hua Wang, Kentaro Yoshinaga, Naoki Mori, Junji Tanaka   +7 more
doaj   +1 more source

Depression and Anxiety After Radiation-Induced Brain Injury: A Review of Current Research Progress

Current Oncology
Radiation therapy serves as a fundamental treatment for primary and metastatic brain tumors, whether used alone or combined with surgery and chemotherapy.
Feng Yang, Rundong Liu, Xiaohong Peng, Na Luo, Min Fu, Wenjun Zhu, Qianxia Li, Guangyuan Hu   +7 more
doaj   +1 more source

The -124C>T Mutation of the TERT Promoter Indicates Favorable Prognosis in Ovarian Clear Cell Carcinoma: A Single Institutional Study in China

Current Oncology
Background: Ovarian clear cell carcinoma (OCCC) is characterized by chemoresistance and poor prognosis in advanced or recurrent cases. This study aimed to find specific prognostic markers for OCCC.
Xiaonan Zhou, Yifei Liu, Jue Hu, Jing Zhang, Min Ren, Gang Ji, Xu Cai, Rui Bi   +7 more
doaj   +1 more source

Sustainable High-Speed Finishing Turning of Haynes 282 Using Carbide Tools in Dry Conditions

Metals, 2019
Nickel-based superalloys exhibit an exceptional combination of corrosion resistance, enhanced mechanical properties at high temperatures, and thermal stability.
A. Díaz-Álvarez, J. Díaz-Álvarez, J. Cantero, H. Miguélez   +3 more
semanticscholar   +1 more source

A Multimodal MRI-Based Model for Colorectal Liver Metastasis Prediction: Integrating Radiomics, Deep Learning, and Clinical Features with SHAP Interpretation

Current Oncology
Purpose: Predicting colorectal cancer liver metastasis (CRLM) is essential for prognostic assessment. This study aims to develop and validate an interpretable multimodal machine learning framework based on multiparametric MRI for predicting CRLM, and to ...
Xin Yan, Furui Duan, Lu Chen, Runhong Wang, Kexin Li, Qiao Sun, Kuang Fu   +6 more
doaj   +1 more source

Synchronous Ovarian Sertoli–Leydig Cell and Clear Cell Papillary Renal Cell Tumors: A Rare Case Without Mutations in Cancer-Associated Genes

Current Oncology
(1) Background: Sertoli–Leydig cell tumors (SLCTs) are rare ovarian neoplasms that account for less than 0.5% of all ovarian tumors. They usually affect young women and often present with androgenic symptoms.
Manuela Macera, Simone Morra, Mario Ascione, Daniela Terracciano, Monica Ianniello, Giovanni Savarese, Carlo Alviggi, Giuseppe Bifulco, Nicola Longo, Annamaria Colao, Paola Ungaro, Paolo Emidio Macchia   +11 more
doaj   +1 more source

Finishing Turning of Ni Superalloy Haynes 282

Metals, 2018
Nickel-based superalloys are widely used in the aeronautical industry, especially in components requiring excellent corrosion resistance, enhanced thermal fatigue properties, and thermal stability.
J. Díaz-Álvarez, A. Díaz-Álvarez, H. Miguélez, J. Cantero   +3 more
semanticscholar   +1 more source

Clinical Impact of CTLA-4 Single-Nucleotide Polymorphism in DLBCL Patients Treated with CAR-T Cell Therapy

Current Oncology
FMC63-CAR T cell therapy targeting CD19 protein on malignant B-cells is effective in patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL), with complete response rates of 43–54%. Common germline variants of the immune-checkpoint
Katja Seipel, Inna Shaforostova, Henning Nilius, Ulrike Bacher, Thomas Pabst   +4 more
doaj   +1 more source