Results 51 to 60 of about 160,488 (298)
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Malignant Melanoma – A Single Institutional Analysis On Real World Data
SVU - International Journal of Medical Sciences, 2023 Background: There are very limited studies on survival analyses of malignant melanoma from the rural and southern part of India and hence we present our retrospective analyses on treatment outcomes of patients diagnosed as Malignant Melanoma from our ...
Sakthi Usha Devi J +3 more
doaj +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Meteorologische Zeitschrift, 2020 Many countries need climate services in order to adapt their development plans to a changing climate. However, not all countries have the resources to provide the full range of climate services themselves.The WMO Regional Climate Centre (WMO RCC) for the
Peter Bissolli +5 more
doaj +1 more source
T and NK cell abundance defines two distinct subgroups of renal cell carcinoma
OncoImmunology, 2022 Renal cell carcinoma (RCC) is considered as an immunogenic cancer. Because not all patients respond to current immunotherapies, we aimed to investigate the immunological heterogeneity of RCC tumors.
Moon Hee Lee +10 more
doaj +1 more source
Kidney Cancer Screening and Epidemiology
Société Internationale d’Urologie Journal, 2022 The incidence of renal cell carcinoma (RCC) has risen worldwide over the past few decades, and this has been associated with a stage shift. Survival outcomes of RCC depend largely on the stage at diagnosis.
Sabrina H. Rossi +5 more
doaj +1 more source
Use of Recycled Crushed Concrete (RCC) Fines for Potential Soil Stabilization [PDF]
, 2016 This study evaluated the use of Recycled Crushed Concrete (RCC) Fines for potential soil stabilization. Soil stabilization is the enhancement of subgrade stability to improve the constructability of successive pavement layers.
Brandon, Varilek +4 more
core +1 more source
Xp11 Translocation Renal Cell Carcinoma (RCC): Extended Immunohistochemical Profile Emphasizing Novel RCC Markers [PDF]
American Journal of Surgical Pathology, 2010 Xp11 translocation renal cell carcinoma (RCC) harbor various TFE3 gene fusions, and are known to underexpress epithelial immunohistochemical (IHC) markers such as cytokeratin and EMA relative to usual adult type RCC; however, their profile in reference to other IHC markers that are differentially expressed in other subtypes of RCC has not been ...
Pedram, Argani +7 more
openaire +2 more sources
Advanced Science, EarlyView.This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang +9 more
wiley +1 more source
Individual cost accounting in the management of medical organizations
Фармакоэкономика, 2019 In the modern economic conditions, the rational planning of costs and the complex process optimization are essential requirements to all organizations.
I. A. Zheleznyakova +2 more
doaj +1 more source