Results 261 to 270 of about 53,016 (292)

Development of Smart Surfaces for Medicine and Biotechnology: Advances in Glass Functionalization through RDRP Techniques

Michał Sroka, Izabela Zaborniak, Paweł Chmielarz   +2 more
openalex   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket-Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target. [PDF]

Adv Sci (Weinh)
Ding X, Zeng D, Liu D, Bian Y, Li B, Li Z, Li Q, Liang S, Si Y, Yao Q, Ding Y, Zhu J, Li X, Zheng K, Guo H, Wang W.   +15 more
europepmc   +1 more source

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Structure-Based Drug Design of RdRp Inhibitors against SARS-CoV-2

Topics in Current Chemistry, 2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human health and life. With over 6 billion confirmed cases of the virus, the need for effective therapeutic drugs has become more urgent than ever before.
Kiran Shehzadi, Afsheen Saba, Mingjia Yu, Jianhuai Liang   +3 more
semanticscholar   +3 more sources

Pharmacophore-based virtual screening and in-silico study of natural products as potential DENV-2 RdRp inhibitors

Journal of Biomolecular Structure and Dynamics, 2023
Dengue fever is a significant public health concern throughout the world, causing an estimated 500,000 hospitalizations and 20,000 deaths each year, despite the lack of effective therapies.
Miah Roney, A. M. Huq, A. R. Issahaku, M. Soliman, Md. Sanower Hossain, Hasnat Mustafa, Md-Alimul Islam, Amit Dubey, A. Tufail, Mohd Fadhlizil Fasihi, M. Aluwi, S. Nizam   +11 more
semanticscholar   +1 more source

HCV RdRp, sofosbuvir and beyond

2021
The therapeutic targeting of the nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) of the Hepatitis C Virus (HCV) with nucleotide analogs led to a deep understanding of this enzymes structure, function and substrate specificity. Unlike previously studied DNA polymerases including the reverse transcriptase of Human Immunodeficiency ...
Joy Y, Feng, Adrian S, Ray
openaire   +2 more sources

Rational Engineering of the DNA Walker Amplification Strategy by Using a Au@Ti3C2@PEI-Ru(dcbpy)32+ Nanocomposite Biosensor for Detection of the SARS-CoV-2 RdRp Gene

ACS Applied Materials and Interfaces, 2021
The detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for preventing and controlling infectious diseases and disease treatment. In this work, a Au@Ti3C2@PEI-Ru(dcbpy)32+ nanocomposite-based electrochemiluminescence (
Bo Yao, Jing Zhang, Zhenqiang Fan, Yuedi Ding, Bin Zhou, Runlin Yang, Jianfeng Zhao, Kai Zhang   +7 more
semanticscholar   +1 more source

Cinnamic acid inhibits Zika virus by inhibiting RdRp activity

Antiviral Research, 2021
In recent years, Zika virus (ZIKV), which causes severe diseases such as congenital microcephaly and Guillain-Barré syndrome, bringing serious harm to humans, has spread throughout the world. However, there are currently no effective drugs against the virus, and the need to develop anti-ZIKV drugs is thus urgent.
Yuting Chen, Zhaoxin Li, Pan Pan, Zizhao Lao, Jiangtao Xu, Zonghui Li, Shaofeng Zhan, Xiaohong Liu, Yina Wu, Wenbiao Wang, Geng Li   +10 more
openaire   +2 more sources

Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA dependent RNA polymerase (RdRp).

Current Medicinal Chemistry, 2021
BACKGROUND SARS-CoV-2, which emerged in Wuhan, China, is a new global threat that has killed millions of people and continues to do so. This pandemic has not only threatened human life but has also triggered economic downturns across the world ...
Shabana Bibi, Mohammad Mehedi Hasan, Yuanbing Wang, Stavros P. Papadakos, Hong Yu   +4 more
semanticscholar   +1 more source

Resveratrol and Its Natural Analogues Inhibit RNA Dependant RNA Polymerase (RdRp) of Rhizopus oryzae in Mucormycosis through Computational Investigations

Polycyclic aromatic compounds (Print), 2022
Mucormycosis (or black fungus infection) is a life-threatening, but rare fungal infection with predominant occurrence in immunosuppressed patients following the SARS-CoV-2 infection. Rhizopus oryzae (R.
I. Celik, M. Rudrapal, P. Yadalam, Sampath Chinnam, Thodur Madapusi Balaji, Saranya Varadarajan, Johra Khan, S. Patil, S. Walode, Dhiraj V. Panke   +9 more
semanticscholar   +1 more source