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Origin and Evolution of RNA-Dependent RNA Polymerase [PDF]
Frontiers in Genetics, 2017 RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias +3 more
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PLoS ONE, 2022 COVID-19 outbreak associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) raised health concerns across the globe and has been considered highly transmissible between people.
Ibrahim Khater, Aaya Nassar
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RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro
Viruses, 2021 Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orthocurvulavirus within the family Orthocurvulaviridae.
Alesia A. Levanova +3 more
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Ribovirus classification by a polymerase barcode sequence [PDF]
PeerJ, 2022 RNA viruses encoding a polymerase gene (riboviruses) dominate the known eukaryotic virome. High-throughput sequencing is revealing a wealth of new riboviruses known only from sequence, precluding classification by traditional taxonomic methods.
Artem Babaian, Robert Edgar
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Inspection on the Mechanism of SARS-CoV-2 Inhibition by Penciclovir: A Molecular Dynamic Study
Molecules, 2022 In recent years, humanity has had to face a critical pandemic due to SARS-CoV-2. In the rapid search for effective drugs against this RNA-positive virus, the repurposing of already existing nucleotide/nucleoside analogs able to stop RNA replication by ...
Micaela Giannetti +3 more
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Microorganisms, 2021 A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has been targeted by numerous inhibitors, e.g., remdesivir ...
Alfredo Mari +24 more
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RNA-dependent RNA Polymerase Assay for Hepatitis E Virus
Bio-Protocol, 2017 RNA-dependent RNA polymerase (RdRp) is essential for the replication of viral RNA for RNA viruses. It synthesizes the complementary strand of viral genomic RNA, which is used subsequently as a template to generate more copies of viral genome.
Vidya Nair +3 more
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Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase
Nature Communications, 2017 Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPβ prophage ofBacillus subtilis, which shares homology to multi-
David Forrest +3 more
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Proceedings, 2020 The Crimean–Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFV as a priority pathogen with an urgent need for enhanced research ...
Egor P. Tchesnokov +3 more
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In vitro RNA-dependent RNA Polymerase Assay Using Arabidopsis RDR6
Bio-Protocol, 2018 RNA-dependent RNA polymerases (RdRPs) in eukaryotes convert single-stranded RNAs into double-stranded RNAs, thereby amplifying small interfering RNAs that play crucial roles in the regulation of development, maintenance of genome integrity and antiviral ...
Kyungmin Baeg +2 more
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