Results 1 to 10 of about 547,551 (257)

SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study

Heliyon, 2020
The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one
Jamshaid Ahmad, Saima Ikram, Fawad Ahmad, Irshad Ur Rehman, Maryam Mushtaq   +4 more
doaj   +3 more sources

Molecular evolution and diversity of the norovirus RNA-dependent RNA polymerase [PDF]

Scientific Reports
Human noroviruses (HuNoVs) are the leading cause of non-bacterial gastroenteritis worldwide, exhibiting extensive genetic diversity driven by recombination and mutation.
Annika Flint, Maryam Jawad, Neda Nasheri
doaj   +2 more sources

Structural and functional characterisation of the Crimean-Congo haemorrhagic fever virus RNA dependent RNA polymerase [PDF]

Nature Communications
Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is found across Africa, Asia, and the Middle East where it can cause Haemorrhagic outbreaks with high case fatality rates.
Adrian Deng, Rory Cunnison, Loïc Carrique, Franziska Günl, Els Pardon, Jan Steyaert, David Nguyen Duc, Jonathan M. Grimes, Nicole Robb, Jeremy R. Keown   +9 more
doaj   +3 more sources

Structures of the Crimean-Congo hemorrhagic fever virus RNA-dependent RNA polymerase [PDF]

Cell Discovery
Crimean-Congo hemorrhagic fever virus (CCHFV), designated by the WHO as a priority pathogen under its R&D Blueprint for emerging epidemics, poses a major global health threat, yet licensed vaccines or specific antiviral treatments are lacking.
Mengyun Li, Kaixiang Zhu, Yanan Liu, Kun Shang, Yuanhao Li, Xinyue Wang, Jianing Wang, Jie Jia, Xin Ai, Dongcun Ni, Sheng Cui, Hongtao Zhu, Xiaopan Gao   +12 more
doaj   +2 more sources

Structure of the RNA-dependent RNA polymerase P2 from the cystovirus φ8 [PDF]

Scientific Reports
The replication of RNA viruses relies on the activity of RNA-dependent RNA polymerases (RdRps). Despite large variations in their genomic sequences, viral RdRps share a common architecture generally known as a closed right hand.
Merlyn Latimer-Smith, Paula S. Salgado, Ismay Forsyth, Eugene Makeyev, Minna M. Poranen, Dave I. Stuart, Jonathan M. Grimes, Kamel El Omari   +7 more
doaj   +2 more sources

Amentoflavone from Selaginella tamariscina inhibits SARS-CoV-2 RNA-dependent RNA polymerase [PDF]

Heliyon
The SARS-CoV-2 pandemic caused millions of deaths due to its prominent infectivity and mortality. Although the vaccines and medicines for SARS-CoV-2 are on the market, new coronavirus variants like influenza are expected to reemerge continuously ...
Kyoung Won Youn, Siyun Lee, Jang Hoon Kim, Yea-In Park, Jaeyeon So, Chansoo Kim, Chong Woon Cho, Junsoo Park   +7 more
doaj   +2 more sources

Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition

Molecules, 2021
The COVID-19 pandemic has caused millions of fatalities since 2019. Despite the availability of vaccines for this disease, new strains are causing rapid ailment and are a continuous threat to vaccine efficacy.
Shah Faisal, Syed Lal Badshah, Bibi Kubra, Mohamed Sharaf, Abdul-Hamid Emwas, Mariusz Jaremko, Mohnad Abdalla   +6 more
doaj   +1 more source

Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)

Molecules, 2021
An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2.
Yifei Wu, David Crich, Scott D. Pegan, Lei Lou, Madelyn C. Hansen, Carson Booth, Ellison Desrochers, Lauren Nicole Mullininx, Edward B. Starling, Kuan Y. Chang, Zhong-Ru Xie   +10 more
doaj   +1 more source

Identification of 6ω-cyclohexyl-2-(phenylamino carbonylmethylthio)pyrimidin-4(3H)-ones targeting the ZIKV NS5 RNA dependent RNA polymerase

Frontiers in Chemistry, 2022
Zika virus (ZIKV), a mosquito-borne flavivirus, is a global health concern because of its association with severe neurological disorders such as neonatal microcephaly and adult Guillain-Barre syndrome.
Guang-Feng Zhou, Guang-Feng Zhou, Cong-Qiang Xie, Jian-Xia Xue, Jian-Xia Xue, Jing-Bo Wang, Yu-Zhuo Yang, Chang-Bo Zheng, Rong-Hua Luo, Ren-Hua Yang, Wen Chen, Liu-Meng Yang, Yue-Ping Wang, Hong-Bin Zhang, Yan-Ping He, Yong-Tang Zheng   +15 more
doaj   +1 more source

Oral GS-441524 derivatives: Next-generation inhibitors of SARS‐CoV‐2 RNA‐dependent RNA polymerase

Frontiers in Immunology, 2022
GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral bioavailability of GS‐441524 poses a challenge to its anti-SARS-CoV-2 efficacy ...
Zhonglei Wang, Zhonglei Wang, Liyan Yang, Xian-qing Song   +3 more
doaj   +1 more source