Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase [PDF]
Nature Communications, 2017 Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPβ prophage ofBacillus subtilis, which shares homology to multi-
David Forrest +3 more
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Molecular evolution and diversity of the norovirus RNA-dependent RNA polymerase [PDF]
Scientific ReportsHuman noroviruses (HuNoVs) are the leading cause of non-bacterial gastroenteritis worldwide, exhibiting extensive genetic diversity driven by recombination and mutation.
Annika Flint, Maryam Jawad, Neda Nasheri
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Origin and Evolution of RNA-Dependent RNA Polymerase [PDF]
Frontiers in Genetics, 2017 RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias +3 more
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Discovery of a Novel Non‐Nucleoside Inhibitor of RNA‐Dependent RNA Polymerase Against Dengue Virus [PDF]
MedCommDengue virus (DENV) is an acute infectious pathogen worldwide, for which no effective therapeutics are available. The RNA‐dependent RNA polymerase (RdRp) displays an important role during DENV replication and is therefore a promising target in the ...
Xue‐Mei He +11 more
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Structure of the RNA-dependent RNA polymerase P2 from the cystovirus φ8 [PDF]
Scientific ReportsThe replication of RNA viruses relies on the activity of RNA-dependent RNA polymerases (RdRps). Despite large variations in their genomic sequences, viral RdRps share a common architecture generally known as a closed right hand.
Merlyn Latimer-Smith +7 more
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Amentoflavone from Selaginella tamariscina inhibits SARS-CoV-2 RNA-dependent RNA polymerase [PDF]
HeliyonThe SARS-CoV-2 pandemic caused millions of deaths due to its prominent infectivity and mortality. Although the vaccines and medicines for SARS-CoV-2 are on the market, new coronavirus variants like influenza are expected to reemerge continuously ...
Kyoung Won Youn +7 more
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RNA-dependent RNA polymerase 1 in potato (Solanum tuberosum) and its relationship to other plant RNA-dependent RNA polymerases [PDF]
, 2011 Cellular RNA-dependent RNA polymerases (RDR) catalyze synthesis of double stranded RNAs that can serve to initiate or amplify RNA silencing. Arabidopsis thaliana has six RDR genes; RDRs 1, 2 and 6 have roles in anti-viral RNA silencing.
Hunter, Lydia JR +7 more
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Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition
Molecules, 2021 The COVID-19 pandemic has caused millions of fatalities since 2019. Despite the availability of vaccines for this disease, new strains are causing rapid ailment and are a continuous threat to vaccine efficacy.
Shah Faisal +6 more
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Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)
Molecules, 2021 An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2.
Yifei Wu +10 more
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Frontiers in Chemistry, 2022 Zika virus (ZIKV), a mosquito-borne flavivirus, is a global health concern because of its association with severe neurological disorders such as neonatal microcephaly and adult Guillain-Barre syndrome.
Guang-Feng Zhou +15 more
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