Results 31 to 40 of about 581,636 (310)

RNA-dependent RNA Polymerase Assay for Hepatitis E Virus

Bio-Protocol, 2017
RNA-dependent RNA polymerase (RdRp) is essential for the replication of viral RNA for RNA viruses. It synthesizes the complementary strand of viral genomic RNA, which is used subsequently as a template to generate more copies of viral genome.
Vidya Nair, Saumya Anang, Akriti Srivastava, Milan Surjit   +3 more
doaj   +1 more source

Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase

Nature Communications, 2017
Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPβ prophage ofBacillus subtilis, which shares homology to multi-
David Forrest, Katherine James, Yulia Yuzenkova, Nikolay Zenkin   +3 more
doaj   +1 more source

Independent Inhibition of the Polymerase and Deubiquitinase Activities of the Crimean–Congo Hemorrhagic Fever Virus Full-Length L-Protein

Proceedings, 2020
The Crimean–Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFV as a priority pathogen with an urgent need for enhanced research ...
Egor P. Tchesnokov, Ben A. Bailey-Elkin, Brian L. Mark, Matthias Götte   +3 more
doaj   +1 more source

Surface for catalysis by poliovirus RNA dependent RNA polymerase [PDF]

Microscopy and Microanalysis, 2012
Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.
Jing, Wang, John M, Lyle, Esther, Bullitt   +2 more
openaire   +2 more sources

Functional characterization of Ysh1p, the yeast endonuclease involved in 3" end processing and in transcription termination of RNA polymerase II transcripts [PDF]

, 2008
Eukaryotic RNA polymerase II (RNAP II) is involved in the synthesis of two major classes of transcripts: messenger RNAs (mRNAs) and small nuclear and small nucleolar RNAs.
Garas, Monika
core   +1 more source

In vitro RNA-dependent RNA Polymerase Assay Using Arabidopsis RDR6

Bio-Protocol, 2018
RNA-dependent RNA polymerases (RdRPs) in eukaryotes convert single-stranded RNAs into double-stranded RNAs, thereby amplifying small interfering RNAs that play crucial roles in the regulation of development, maintenance of genome integrity and antiviral ...
Kyungmin Baeg, Yukihide Tomari, Hiro-oki Iwakawa   +2 more
doaj   +1 more source

PAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif [PDF]

, 2011
PAPD5 is one of the seven members of the family of noncanonical poly(A) polymerases in human cells. PAPD5 was shown to polyadenylate aberrant pre-ribosomal RNAs in vivo, similar to degradation-mediating polyadenylation by the noncanonical poly(A ...
Bilen, B., Keller, W., Mihaela Zavolan, Biter Bilen, Zavolan, M., Walter Keller, Rammelt, C., Christiane Rammelt   +7 more
core   +1 more source

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation [PDF]

, 2013
Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs.
Porter, Andrew C. G., Panov, Konstantin I; id_orcid, Zomerdijk, Joost C.B.M., Russell, J., Miller, G. (Gail), Zomerdijk, Joost C B M, Porter, A.C., Porter, Andrew C G, Volkov, A., Panov, K.I., Panov, Konstantin I., Russell, J. (Jackie), Panova, T., Zomerdijk, J.C., Miller, Gail, Porter, Andrew C.G., Miller, G., Panova, Tatiana, Russell, Jackie, Ray, S., Ray, Swagat, Volkov, Arsen, Zomerdijk, Joost C. B. M.   +22 more
core   +1 more source

Identification of Potential Key Agents for Targeting RNA-Dependent RNA Polymerase of SARS-CoV-2 by Integrated Analysis and Virtual Drug Screening

Frontiers in Genetics, 2020
BackgroundRNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for the SARS-CoV-2 replication process and catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA, often recognized as good targets for antiviral ...
Shuang Ao, Dan Han, Lei Sun, Yanhong Wu, Yanhong Wu, Shuang Liu, Shuang Liu, Yaojiang Huang, Yaojiang Huang   +8 more
doaj   +1 more source

Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea. [PDF]

, 2009
Contains fulltext : 80405.pdf (Publisher’s version ) (Open Access)One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the ...
Makarova, K.S., Siebers Bettina, Koonin Eugene V, Bettina Siebers, Siebers, B.G., Kira S Makarova, Blombach Fabian, Fabian Blombach, Makarova Kira S, John Oost, Koonin, E.V., Oost, J., van der, Siebers, B., Marrero, J., Oost John, van der Oost, J., Blombach, F., Oost, J. van der, Marrero Jeannette, Jeannette Marrero, Eugene V Koonin   +20 more
core   +1 more source