Results 51 to 60 of about 4,143,061 (301)

RNA-dependent RNA polymerases of dsRNA bacteriophages

Virus Research, 2004
Genome replication and transcription of riboviruses are catalyzed by an RNA-dependent RNA polymerase (RdRP). RdRPs are normally associated with other virus- or/and host-encoded proteins that modulate RNA polymerization activity and template specificity. The polymerase complex of double-stranded dsRNA viruses is a large icosahedral particle (inner core)
Makeyev, E, Grimes, J
openaire   +3 more sources

NeoRdRp2 with improved seed data, annotations, and scoring

Frontiers in Virology
RNA-dependent RNA polymerase (RdRp) is a marker gene for RNA viruses; thus, it is widely used to identify RNA viruses from metatranscriptome data. However, because of the high diversity of RdRp domains, it remains difficult to identify RNA viruses using ...
Shoichi Sakaguchi, Takashi Nakano, So Nakagawa, So Nakagawa, So Nakagawa   +4 more
doaj   +1 more source

6S RNA-Dependent Susceptibility to RNA Polymerase Inhibitors

Antimicrobial Agents and Chemotherapy, 2022
Bacterial small RNAs (sRNAs) contribute to a variety of regulatory mechanisms that modulate a wide range of pathways, including metabolism, virulence, and antibiotic resistance. We investigated the involvement of sRNAs in rifampicin resistance in the opportunistic pathogen Staphylococcus aureus
Esberard, Marick, Hallier, Marc, Liu, Wenfeng, Morvan, Claire, Bossi, Lionello, Figueroa-Bossi, Nara, Felden, Brice, Bouloc, Philippe   +7 more
openaire   +2 more sources

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle. [PDF]

, 2011
RNA polymerase I (Pol I) produces large ribosomal RNAs (rRNAs). In this study, we show that the Rpa49 and Rpa34 Pol I subunits, which do not have counterparts in Pol II and Pol III complexes, are functionally conserved using heterospecific ...
Gadal, O., Leger-Silvestre, Isabelle, Ostermaier, M.K., Panov, Konstantin; id_orcid, Panov, Kostya I, Schultz, P., Leger-Silvestre, I. (I), Olivier Gadal, Jorge Pérez-Fernández, Albert, Benjamin, Leger-Silvestre, I., Ostermaier, Martin K, Kostya I. Panov, Perez-Fernandez, J., Normand, C. (C), Schultz, Patrick, Schultz, P. (Patrick), Panov, Kostya I., Patrick Schultz, Gadal, O. (O), Normand, Christophe, Martin K. Ostermaier, Normand, C., Zomerdijk, Joost C.B.M., Albert, B. (B), Perez-Fernandez, J. (J), Ostermaier, M. (M) K. (K), Ostermaier, Martin K., Christophe Normand, Zomerdijk, Joost C B M, Gadal, Olivier, Joost C.B.M. Zomerdijk, Zomerdijk, J.C., Perez-Fernandez, Jorge, Isabelle Léger-Silvestre, Albert, B., Panov, K. (K) I. (I), Zomerdijk, Joost C. B. M., Benjamin Albert, Zomerdijk, J. (J) C. (C)   +39 more
core   +1 more source

Targeting Emerging RNA Viruses by Engineered Human Superantibody to Hepatitis C Virus RNA-Dependent RNA Polymerase

Frontiers in Microbiology, 2022
RNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this protein.
Kittirat Glab-ampai, Kanasap Kaewchim, Kanasap Kaewchim, Techit Thavorasak, Techit Thavorasak, Thanatsaran Saenlom, Watayagorn Thepsawat, Kodchakorn Mahasongkram, Kanyarat Thueng-In, Nitat Sookrung, Nitat Sookrung, Wanpen Chaicumpa, Monrat Chulanetra   +12 more
doaj   +1 more source

Domain orientation in the RNA helicase YxiN and the role of conformational changes for RNA unwinding [PDF]

, 2010
The RNA helicase YxiN from Bacillus subtilis is a member of the family of DEAD box proteins. YxiN is able to unwind RNA double strands in an ATP-dependent manner. The ability to catalyse RNA rearrangement is in vivo presumably necessary for the bacterial
Karow, Anne R.
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers. [PDF]

, 2014
We have previously documented the inhibitory activity of RNA aptamers to the RNA-dependent RNA polymerase of foot-and-mouth disease virus (3D(pol)). Here we report their modification and use with a subgenomic replicon incorporating GFP (pGFP-PAC replicon)
Forrest, S, Lear, Z, Ryan, M., Herod, M, Forrest, S., Ryan, M, Stonehouse, N.J., Rowlands, DJ, Herod, M.R., Stonehouse, NJ, Lear, Z., Rowlands, D.J.   +11 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A Perspective on the Enhancer Dependent Bacterial RNA Polymerase

Biomolecules, 2015
Here we review recent findings and offer a perspective on how the major variant RNA polymerase of bacteria, which contains the sigma54 factor, functions for regulated gene expression.
Nan Zhang, Martin Buck
doaj   +1 more source