Results 61 to 70 of about 4,143,061 (301)

An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]

, 2007
RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid, Stuart, Kenneth, Ernst, Nancy Lewis, Fleck, Michele, Babbarwal, Vinod Kumar   +4 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A new yeast poly(A) polymerase complex involved in RNA quality control [PDF]

, 2005
Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors.
Sabine Dettwiler (27038), Arno Friedlein (27039), Keller Walter, Stepánka Vanácová, Vanacova, S., Blank Diana, Martin Georges, Gérard Keith, Keller, W., Sabine Dettwiler, Jeannette Wolf (27035), Langen, H., Keith, G., Diana Blank (27037), Vanˇácˇová Sˇteˇpánka, Vanácová Stepánka, Georges Martin, Hanno Langen, Diana Blank, Hanno Langen (27040), Gérard Keith (27041), Keith Gérard, Walter Keller (27042), Wolf, J., Jeannette Wolf, Blank, D., Arno Friedlein, Wolf Jeannette, Štěpánka Vaňáčová (27034), Walter Keller, Friedlein, A., Langen Hanno, Friedlein Arno, Dettwiler, S., Dettwiler Sabine, Georges Martin (27036), Martin, G.   +36 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Analyses of the archaeal transcription cycle reveal a mosaic of eukaryotic RNA polymerase II and III-like features [PDF]

, 2009
Novel mechanistic properties of the archaeal transcription system that reveal similarities especially to the eukaryotic RNA polymerase II and III systems were presented in thesis.
Spitalny, Patrizia
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Functional Importance of the Hydrophobic Residue 362 in Influenza A PB1 Subunit

Viruses, 2023
PB1, acting as the catalytic subunit of the influenza polymerase, has numerous sequentially and structurally conserved regions. It has been observed that the slight modification of residues in PB1 would greatly affect the polymerase activity and even ...
Johnson Jor-Shing Chan, Yun-Sang Tang, Chun-Yeung Lo, Pang-Chui Shaw   +3 more
doaj   +1 more source

Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages [PDF]

, 2015
Date of Acceptance: 02/01/2015Small RNA pathways act at the front line of defence against transposable elements across the Eukaryota. In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence.
Jones, John T., Murray E Selkirk, John T Jones, Goldstein, R, Phillip M. Schiffer (691095), Bob Goldstein, Miska, E A, Taylor, Mark J., Eric A. Miska (41828), Blaxter, Mark L., Murray E. Selkirk (202480), Miska, Eric A., Christopher Kraus (691096), John T. Jones (207247), Fast, Naomi M., Sarkies, P, Peter Sarkies (691090), Alex Ardila-Garcia, Ben Hanelt (107535), Blok, V, Schiffer, Phillip M., Georgios Koutsovoulos (556628), Hanelt, Ben, Georgios Koutsovoulos, Boothby, Thomas, Ben Hanelt, Naomi M. Fast (691094), Koutsovoulos, Georgios, Mark J Taylor, Bob Goldstein (265221), Selkirk, Murray E., Phillip M Schiffer, Ardila-Garcia, Alex, Eric A Miska, Alex Ardila-Garcia (691093), Thomas Boothby, Hanelt, B, Mark J. Taylor (118298), Thomas Boothby (691092), Mark L. Blaxter (115482), Selkirk, M E, Vivian Blok (691091), Blok, Vivian, Naomi M Fast, Taylor, Mark; id_orcid, Kraus, C, Schiffer, P M, Sarkies, Peter, Jones, J T, Goldstein, Bob, Fast, N M, Christopher Kraus, Koutsovoulos, G, Taylor, M J, Ardila-Garcia, A, Mark L Blaxter, Kraus, Christopher, Blaxter, M L, Boothby, T, Peter Sarkies, Vivian Blok   +60 more
core   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Identifying Different Mutation Sites Leading to Resistance to the Direct-Acting Antiviral (DAA) Sofosbuvir in Hepatitis C Virus Patients from Egypt

Microorganisms, 2022
The hepatitis C virus (HCV) is a major global health challenge and a leading cause of morbidity and mortality. Many direct-acting antivirals (DAAs) target essential macromolecules involved in the virus’ life cycle.
Aly Atef Shoun, Rania Abozahra, Kholoud Baraka, Mai Mehrez, Sarah M. Abdelhamid   +4 more
doaj   +1 more source