Results 41 to 50 of about 581,636 (310)

Electron Density Analysis of SARS-CoV-2 RNA-Dependent RNA Polymerase Complexes

Molecules, 2021
The work is devoted to the study of the complementarity of the electronic structures of the ligands and SARS-CoV-2 RNA-dependent RNA polymerase. The research methodology was based on determining of 3D maps of electron densities of complexes using an ...
Nadezhda Palko, Maria Grishina, Vladimir Potemkin   +2 more
doaj   +1 more source

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P   +22 more
core   +1 more source

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

Nature Communications, 2017
The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the ...
Andre S. Godoy, Gustavo M. A. Lima, Ketllyn I. Z. Oliveira, Naiara U. Torres, Fernando V. Maluf, Rafael V. C. Guido, Glaucius Oliva   +6 more
doaj   +1 more source

Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]

, 2007
A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David, Dlakic, Mensur, Dez, Christophe   +2 more
core   +1 more source

Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B

Viruses, 2010
More than 20 years after the identification of the hepatitis C virus (HCV) as a novel human pathogen, the only approved treatment remains a combination of pegylated interferon-α and ribavirin.
Megan H. Powdrill, Matthias Götte, Jean A. Bernatchez   +2 more
doaj   +1 more source

An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]

, 2013
Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354), Jack O Phillips, Anastasia J Callaghan, Vincent, H., Andrew R. Pickford (485355), Adam J Roberts, Louise E. Butt (485353), Stone, Carlanne, Charlotte E. Mardle (485352), Henderson, Charlotte, Adam J. Roberts (485350), Pickford, Andy, Carlanne M Stone, Roberts, Adam J., Butt, Louise, Charlotte A Henderson, Louise E Butt, Anastasia J. Callaghan (485356), Helen A Vincent, Charlotte E Mardle, Callaghan, Anastasia, Carlanne M. Stone (485351), Phillips, Jack, Jack O. Phillips (485348), Charlotte A. Henderson (485349), Gowers, Darren, Mardle, C., Andrew R Pickford, Helen A. Vincent (485347), Darren M Gowers   +29 more
core   +1 more source

Targeting Emerging RNA Viruses by Engineered Human Superantibody to Hepatitis C Virus RNA-Dependent RNA Polymerase

Frontiers in Microbiology, 2022
RNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this protein.
Kittirat Glab-ampai, Kanasap Kaewchim, Kanasap Kaewchim, Techit Thavorasak, Techit Thavorasak, Thanatsaran Saenlom, Watayagorn Thepsawat, Kodchakorn Mahasongkram, Kanyarat Thueng-In, Nitat Sookrung, Nitat Sookrung, Wanpen Chaicumpa, Monrat Chulanetra   +12 more
doaj   +1 more source

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle. [PDF]

, 2011
RNA polymerase I (Pol I) produces large ribosomal RNAs (rRNAs). In this study, we show that the Rpa49 and Rpa34 Pol I subunits, which do not have counterparts in Pol II and Pol III complexes, are functionally conserved using heterospecific ...
Gadal, O., Leger-Silvestre, Isabelle, Ostermaier, M.K., Panov, Konstantin; id_orcid, Panov, Kostya I, Schultz, P., Leger-Silvestre, I. (I), Olivier Gadal, Jorge Pérez-Fernández, Albert, Benjamin, Leger-Silvestre, I., Ostermaier, Martin K, Kostya I. Panov, Perez-Fernandez, J., Normand, C. (C), Schultz, Patrick, Schultz, P. (Patrick), Panov, Kostya I., Patrick Schultz, Gadal, O. (O), Normand, Christophe, Martin K. Ostermaier, Normand, C., Zomerdijk, Joost C.B.M., Albert, B. (B), Perez-Fernandez, J. (J), Ostermaier, M. (M) K. (K), Ostermaier, Martin K., Christophe Normand, Zomerdijk, Joost C B M, Gadal, Olivier, Joost C.B.M. Zomerdijk, Zomerdijk, J.C., Perez-Fernandez, Jorge, Isabelle Léger-Silvestre, Albert, B., Panov, K. (K) I. (I), Zomerdijk, Joost C. B. M., Benjamin Albert, Zomerdijk, J. (J) C. (C)   +39 more
core   +1 more source

RNA-dependent RNA polymerases of dsRNA bacteriophages

Virus Research, 2004
Genome replication and transcription of riboviruses are catalyzed by an RNA-dependent RNA polymerase (RdRP). RdRPs are normally associated with other virus- or/and host-encoded proteins that modulate RNA polymerization activity and template specificity. The polymerase complex of double-stranded dsRNA viruses is a large icosahedral particle (inner core)
Makeyev, E, Grimes, J
openaire   +3 more sources

An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]

, 2007
RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid, Stuart, Kenneth, Ernst, Nancy Lewis, Fleck, Michele, Babbarwal, Vinod Kumar   +4 more
core   +1 more source