Results 11 to 20 of about 581,636 (310)
Origin and Evolution of RNA-Dependent RNA Polymerase [PDF]
Frontiers in Genetics, 2017 RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias +3 more
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Reticulocyte RNA-Dependent RNA Polymerase [PDF]
Proceedings of the National Academy of Sciences, 1973 A cytoplasmic, microsomal bound RNA-dependent RNA polymerase has been purified 2500-fold from rabbit reticulocyte lysates. The synthesis of RNA with the purified enzyme is absolutely dependent on the addition of an RNA template. The best template is hemoglobin messenger RNA, while bacteriophage RNA and poly(A,G) are less active, and DNA is completely ...
K M, Downey +3 more
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The Rna-Dependent RNA Polymerase of the Influenza a Virus [PDF]
Future Virology, 2014 The influenza A virus causes a highly contagious respiratory disease that significantly impacts our economy and health. Its replication and transcription is catalyzed by the viral RNA polymerase. This enzyme is also crucial for the virus, because it is involved in the adaptation of zoonotic strains.
Stubbs, T, te Velthuis, A
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Inhibitors of an RNA‐dependent DNA polymerase [PDF]
FEBS Letters, 1971 Much interest of late has centered around RNAdirected DNA synthesis. Initially, with the finding of an RNA-dependent DNA polymerase in oncogenic RNA viruses [l-S] and what was described as the exclusive presence of the polymerase in acute leukemia cells as opposed to ‘normal’ cells [6] , speculation as to a molecular basis for leukemogenesis and a ...
Bosmann, H.Bruce, Kessel, David
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Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase
Microorganisms, 2021 Coronavirus Disease 2019 (COVID-19) is a deadly emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Because SARS-CoV-2 is easily transmitted through the air and has a relatively long incubation time, COVID ...
Keivan Zandi +14 more
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Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. [PDF]
PLoS ONE, 2014 Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp).
Romina Croci +10 more
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RNA-dependent RNA polymerase of tobacco plants [PDF]
Proceedings of the National Academy of Sciences, 1978 Several properties of RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) active fractions obtained from tobacco plants, be they uninfected, infected with tobacco mosaic virus, or infected with tobacco necrosis virus, were compared.
M, Ikegami, H, Fraenkel-Conrat
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PLoS ONE, 2022 COVID-19 outbreak associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) raised health concerns across the globe and has been considered highly transmissible between people.
Ibrahim Khater, Aaya Nassar
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Molecular Evolution of RNA-Dependent RNA Polymerase Region in Norovirus Genogroup I
Viruses, 2023 Norovirus is the leading viral agent of gastroenteritis in humans. RNA-dependent RNA polymerase (RdRp) is essential in the replication of norovirus RNA. Here, we present a comprehensive evolutionary analysis of the norovirus GI RdRp gene.
Nan Zhou +4 more
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Structure of the RNA-dependent RNA polymerase of poliovirus [PDF]
Structure, 1997 The central player in the replication of RNA viruses is the viral RNA-dependent RNA polymerase. The 53 kDa poliovirus polymerase, together with other viral and possibly host proteins, carries out viral RNA replication in the host cell cytoplasm. RNA-dependent RNA polymerases comprise a distinct category of polymerases that have limited sequence ...
Hansen, Jeffrey L +2 more
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