Results 11 to 20 of about 583,250 (311)
Oral GS-441524 derivatives: Next-generation inhibitors of SARS‐CoV‐2 RNA‐dependent RNA polymerase
Frontiers in Immunology, 2022 GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral bioavailability of GS‐441524 poses a challenge to its anti-SARS-CoV-2 efficacy ...
Zhonglei Wang +3 more
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Inhibitors of an RNA‐dependent DNA polymerase [PDF]
FEBS Letters, 1971 Much interest of late has centered around RNAdirected DNA synthesis. Initially, with the finding of an RNA-dependent DNA polymerase in oncogenic RNA viruses [l-S] and what was described as the exclusive presence of the polymerase in acute leukemia cells as opposed to ‘normal’ cells [6] , speculation as to a molecular basis for leukemogenesis and a ...
Bosmann, H.Bruce, Kessel, David
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Cell penetrable humanized-VH/V(H)H that inhibit RNA dependent RNA polymerase (NS5B) of HCV. [PDF]
PLoS ONE, 2012 NS5B is pivotal RNA dependent RNA polymerase (RdRp) of HCV and NS5B function interfering halts the virus infective cycle. This work aimed to produce cell penetrable humanized single domain antibodies (SdAb; VH/V(H)H) that interfere with the RdRp activity.
Kanyarat Thueng-in +7 more
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Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase
Microorganisms, 2021 Coronavirus Disease 2019 (COVID-19) is a deadly emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Because SARS-CoV-2 is easily transmitted through the air and has a relatively long incubation time, COVID ...
Keivan Zandi +14 more
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RNA-dependent RNA polymerase of tobacco plants [PDF]
Proceedings of the National Academy of Sciences, 1978 Several properties of RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) active fractions obtained from tobacco plants, be they uninfected, infected with tobacco mosaic virus, or infected with tobacco necrosis virus, were compared.
M, Ikegami, H, Fraenkel-Conrat
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Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. [PDF]
PLoS ONE, 2014 Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp).
Romina Croci +10 more
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Molecular Evolution of RNA-Dependent RNA Polymerase Region in Norovirus Genogroup I
Viruses, 2023 Norovirus is the leading viral agent of gastroenteritis in humans. RNA-dependent RNA polymerase (RdRp) is essential in the replication of norovirus RNA. Here, we present a comprehensive evolutionary analysis of the norovirus GI RdRp gene.
Nan Zhou +4 more
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Structure of the RNA-dependent RNA polymerase of poliovirus [PDF]
Structure, 1997 The central player in the replication of RNA viruses is the viral RNA-dependent RNA polymerase. The 53 kDa poliovirus polymerase, together with other viral and possibly host proteins, carries out viral RNA replication in the host cell cytoplasm. RNA-dependent RNA polymerases comprise a distinct category of polymerases that have limited sequence ...
Hansen, Jeffrey L +2 more
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PLoS ONE, 2022 COVID-19 outbreak associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) raised health concerns across the globe and has been considered highly transmissible between people.
Ibrahim Khater, Aaya Nassar
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The Functions of RNA-Dependent RNA Polymerases in Arabidopsis [PDF]
The Arabidopsis Book, 2011 One recently identified mechanism that regulates mRNA abundance is RNA silencing, and pioneering work in Arabidopsis thaliana and other genetic model organisms helped define this process. RNA silencing pathways are triggered by either self-complementary fold-back structures or the production of double-stranded RNA (dsRNA) that gives rise to small RNAs (
Matthew R, Willmann +3 more
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