Results 271 to 280 of about 53,016 (292)

Fluorometric RdRp assay with self-priming RNA

Virus Genes, 2015
There is an outmost need for the identification of specific antiviral compounds. Current antivirals lack specificity, making them susceptible to off-target effects, and highlighting importance of development of assays to discover antivirals targeting viral specific proteins.
Fatih, Kocabas, Raife D, Turan, Galip S, Aslan   +2 more
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Repositioning Therapeutics for SARS-CoV-2: Virtual Screening of Plant-based Anti-HIV Compounds as Possible Inhibitors against COVID-19 Viral RdRp.

Current pharmaceutical design, 2022
BACKGROUND Coronavirus disease 2019 (COVID-19) has caused a global pandemic with a high mortality and morbidity rate worldwide. The COVID-19 vaccines that are currently in development or already approved are expected to provide at least some protection ...
M. Murali, H. G. Gowtham, M. Ansari, M. Alomary, Saad Alghamdi, M. Almehmadi, S. Singh, N. Shilpa, M. Aiyaz, Nataraj Kalegowda, A. Ledesma, K. N. Amruthesh   +11 more
semanticscholar   +1 more source

Quinoline and Quinazoline Derivatives Inhibit Viral RNA Synthesis by SARS-CoV-2 RdRp

ACS Infectious Diseases, 2021
Coronavirus disease 2019 (COVID-19) is a fatal respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The identification of potential drugs is urgently needed to control the pandemic.
Jian-yuan Zhao, Yongxin Zhang, Minghua Wang, Qian Liu, X. Lei, Meng Wu, Saisai Guo, Dong-Rong Yi, Quanjie Li, Ling Ma, Zhenlong Liu, Fei Guo, Jianwei Wang, Xiaoyu Li, Yucheng Wang, S. Cen   +15 more
semanticscholar   +1 more source

In silico identification of novel benzophenone–coumarin derivatives as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors

Journal of Biomolecular Structure and Dynamics, 2021
In this study, we propose our novel benzophenone–coumarin derivatives (BCDs) as potent inhibitors of the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 virus, one of the key targets that are involved in the viral genome replication. We aim to evaluate
Shashank M. Patil, R. M. Martiz, R. Ramu, Prithvi S Shirahatti, A. Prakash, J. Chandra S, V. L. Ranganatha   +6 more
semanticscholar   +1 more source

Bunyaviridae RdRps: structure, motifs, and RNA synthesis machinery

Critical Reviews in Microbiology, 2017
Bunyaviridae family is the largest and most diverse family of RNA viruses. It has more than 350 members divided into five genera: Orthobunyavirus, Phlebovirus, Nairovirus, Hantavirus, and Tospovirus. They are present in the five continents, causing recurrent epidemics, epizootics, and considerable agricultural loss.
Abdennour Amroun, Stéphane Priet, Xavier de Lamballerie, Gilles Quérat   +3 more
openaire   +2 more sources

Black tea bioactives as inhibitors of multiple targets of SARS-CoV-2 (3CLpro, PLpro and RdRp): a virtual screening and molecular dynamic simulation study

Journal of Biomolecular Structure and Dynamics, 2021
The global pandemic due to the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has taken more than a million lives. Lack of definitive vaccine/drugs against this highly contagious virus has accelerated exploratory research on novel ...
M. Gogoi, Meghali Borkotoky, S. Borchetia, P. Chowdhury, Saurav Mahanta, A. Barooah   +5 more
semanticscholar   +1 more source

Revealing the Inhibition Mechanism of RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2 by Remdesivir and Nucleotide Analogues: A Molecular Dynamics Simulation Study.

Journal of Physical Chemistry B, 2020
Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious global health issue. Remdesivir is the first antiviral compound approved by the US FDA for the SARS-CoV-2 treatment for emergency use, targeting RNA-dependent RNA ...
Padmaja D. Wakchaure, Shibaji Ghosh, B. Ganguly   +2 more
semanticscholar   +1 more source

High genetic diversity in RdRp gene of Brazilian porcine sapovirus strains

Veterinary Microbiology, 2008
Sapovirus is one genus within Caliciviridae family that causes diarrhea in humans and animals. Sapovirus (SaV) has been classified into seven genogroups (GI to GVII). The GIII, GVI, and GVII, which prototype is Cowden, JJ681, and K7/JP strains, respectively, infect pigs.
Aline F, Barry, Alice F, Alfieri, Amauri A, Alfieri   +2 more
openaire   +2 more sources

Opportunities for dual RDRP agents in synthesizing novel polymeric materials

Polymer Chemistry, 2017
Dual RDRP agents provide access to new polymeric materials by combining ATRP, NMP, and RAFT polymerization without end group transformations.
Samuel Pearson, Claude St Thomas, Ramiro Guerrero-Santos, Franck D'Agosto   +3 more
openaire   +1 more source

ANALISIS GEN RDRP PADA VARIAN VIRUS SARS COV-2 [PDF]

, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) teridentifikasi pertama kali di Wuhan pada Desember 2019. Infeksi SARS CoV-2 terus mengalami perkembangan akibat terjadinya mutasi pada genom virus sehingga menyebabkan munculnya varian virus baru. Salah satu gen yang mengalami mutasi pada SARS CoV-2 adalah RNA-dependent RNA polymerase (RdRp),
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