Results 101 to 110 of about 2,217,168 (245)

Investigation on Transverse Loading of Auxetic Beams Using Finite Element Methods

Engineering Proceedings
Structures that possess negative Poisson’s ratio are termed “Auxetic” structures. They elongate laterally on longitudinal–tensile loading and compress laterally on longitudinal–compressive loading.
Navneeth Sanjeev, M. P. Hariprasad
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Re-entrant jet mechanism for periodic cavitation shedding in a cylindrical orifice

, 2014
Periodic shedding of cloud cavitation is a common form of cavitation instability. The motion of a reentrant liquid jet is central to this process but the mechanism which drives the phenomenon remains unclear, particularly for cavitation in cylindrical ...
Cameron Stanley (18044878), Tracie Barber (7114154), Gary Rosengarten (18029431)   +2 more
core  

Metallic Metamaterials with Auxetic Properties: Re-Entrant Structures

Metals
The present article is an exploration of metamaterial structures exhibiting auxetic properties. The study shows the effect of three geometric parameters of re-entrant auxetic cells, namely, the internal initial cell angle (θ0), the strut length ratio h/l,
Julian Plewa, Małgorzata Płońska, Grzegorz Junak   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

On the detection of re-entrant features from metal additively manufactured samples and their correlations with manufacturing parameters

Frontiers in Materials
Metal additive manufacturing (AM), particularly laser powder bed fusion (L-PBF), often yields complex surface topographies that include re-entrant features—undercut geometries that cannot be detected or quantified using conventional surface metrology ...
Tomasz Bartkowiak, Michał Jakubowicz, Patryk Mietliński, Michał Wieczorowski   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Investigation of mechanical properties of re-entrant structure [PDF]

, 2019
Fen Bilimleri Enstitüsü, İnşaat Mühendisliği Ana Bilim DalıKonvansiyonel girintili (re-entrant) yapı düşük rijitliğe sahip bir hücre yapısıdır. Girintili yapının rijitliğinin ve mekanik özelliklerinin artırılması kullanım alanlarının genişlemesini ...
Öztürk, Mitat
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source