Results 111 to 120 of about 1,530,649 (296)

Re-entrant jet mechanism for periodic cavitation shedding in a cylindrical orifice

, 2014
Periodic shedding of cloud cavitation is a common form of cavitation instability. The motion of a reentrant liquid jet is central to this process but the mechanism which drives the phenomenon remains unclear, particularly for cavitation in cylindrical ...
Cameron Stanley (18044878), Tracie Barber (7114154), Gary Rosengarten (18029431)   +2 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Investigation on Transverse Loading of Auxetic Beams Using Finite Element Methods

Engineering Proceedings
Structures that possess negative Poisson’s ratio are termed “Auxetic” structures. They elongate laterally on longitudinal–tensile loading and compress laterally on longitudinal–compressive loading.
Navneeth Sanjeev, M. P. Hariprasad
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Upconversion of phonon modes into microwave photons in a lithium niobate bulk acoustic wave resonator coupled to a microwave cavity

APL Photonics
The coupling between acoustic vibrations in a lithium niobate bulk acoustic wave resonator and microwave photons of a re-entrant microwave cavity was investigated at a temperature close to 4 K.
S. Parashar, W. M. Campbell, J. Bourhill, E. Ivanov, M. Goryachev, M. E. Tobar   +5 more
doaj   +1 more source

Metallic Metamaterials with Auxetic Properties: Re-Entrant Structures

Metals
The present article is an exploration of metamaterial structures exhibiting auxetic properties. The study shows the effect of three geometric parameters of re-entrant auxetic cells, namely, the internal initial cell angle (θ0), the strut length ratio h/l,
Julian Plewa, Małgorzata Płońska, Grzegorz Junak   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

On the detection of re-entrant features from metal additively manufactured samples and their correlations with manufacturing parameters

Frontiers in Materials
Metal additive manufacturing (AM), particularly laser powder bed fusion (L-PBF), often yields complex surface topographies that include re-entrant features—undercut geometries that cannot be detected or quantified using conventional surface metrology ...
Tomasz Bartkowiak, Michał Jakubowicz, Patryk Mietliński, Michał Wieczorowski   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source