Results 51 to 60 of about 2,217,168 (245)

Pathway and directional specificity of Hebbian plasticity in the cortical visual motion processing network

iScience, 2023
Summary: Cortico-cortical paired associative stimulation (ccPAS), which repeatedly pairs single-pulse transcranial magnetic stimulation (TMS) over two distant brain regions, is thought to modulate synaptic plasticity. We explored its spatial selectivity (
Michele Bevilacqua, Krystel R. Huxlin, Friedhelm C. Hummel, Estelle Raffin   +3 more
doaj   +1 more source

Mechanics of novel asymmetrical re-entrant metamaterials and metastructures [PDF]

, 2022
In this work, we evaluate the mechanical performance of an innovative asymmetrical re-entrant metamaterial configuration via finite element (FEM) models.
Li, Zhenyu, Wang, Xintao, Wang, Jinwu, Zhang, Wenjiao, Scarpa, Fabrizio   +4 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Vibration attenuation using a 3D cubic re-entrant metamaterial structure with tunable bandgaps induced by variations in the re-entrant angle

EPJ Applied Metamaterials
This study explores the vibration attenuation capabilities of three-dimensional metamaterial periodic structures, leveraging the properties of auxetic structures and phononic crystals in forming bandgaps.
Abubakar Musa, Shi Huaitao, Bai Xiaotian, Yang Tianzhi, Zhang Ke, Sun Xianming   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Re-entrant Isotropic Phase between Lamellar and Columnar Mesophases

, 2016
Tetradental cis-enaminoketone Ni (II) complexes with different molecular shape have been synthesized. Intramolecular hydrogen bonds, which stiffen the mesogenic core and restrict rotation of some molecular parts, have been introduced in these compounds ...
Adam Krówczyński (2719717), Damian Pociecha (654194), Urszula Pietrasik (2719723), Daniel Guillon (1768156), Ewa Górecka (2989554), Jadwiga Szydłowska (2719720)   +5 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Additive Manufacture of 3D Auxetic Structures by Laser Powder Bed Fusion—Design Influence on Manufacturing Accuracy and Mechanical Properties

Applied Sciences, 2020
The mechanical response of steel auxetic structures manufactured using laser-powder bed fusion was explored. The level of control exerted by the key design parameters of vertical strut length (H), re-entrant strut length (L), strut thickness (t) and re ...
Sibi Maran, Iain G. Masters, Gregory J. Gibbons   +2 more
doaj   +1 more source