Results 131 to 140 of about 7,532,149 (298)

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

SUBVERSIVE FLORI.CULTURES. Ecological manoeuvres from the re-existing South

, 2017
The article deals with the need to approach a decolonial critique of the notion of nature, both in its theoretical and methodological dimension, since it has been clearly reified by Western scientific knowledge to sustain inequalities of power or the ...
Romero Caballero, Belén
core  

Bipolar Palladium Membrane Enabling Crossover‐Free Selective Proton Transport

Advanced Science, EarlyView.
This study introduces a crossover‐free bipolar palladium membrane that transports protons selectively via reversible Pd/PdHx absorption–desorption and lattice hydrogen diffusion, overcoming the conductivity–selectivity trade‐off of polymer membranes. It enables water‐fed Li‐mediated ammonia synthesis, achieving 51% Faradaic efficiency and stable 12 h ...
Jiyeon Baek, Yeongbae Jeon, Seunga Lee, Ahee Choi, Joonmok Shim, Kyungho Lee, Ho Woun Jung, Sun Hyung Kim, Churl Hee Cho, Hyung Chul Yoon, Yun Jeong Hwang, Jae Hyung Kim   +11 more
wiley   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

FLORI.CULTURAS SUBVERSIVAS Maniobras ecológicas desde el Sur re-existente

, 2017
El texto trata sobre la necesidad de abordar una crítica descolonial a la noción de naturaleza, tanto en su dimensión teórica como metodológica, pues ha sido claramente reificada por el conocimiento científico occidental para sostener desigualdades de ...
Romero Caballero, Belén
core   +12 more sources

Promoting Electroreduction CO2 to Multi‐Carbon Products by Tailoring the *H Availability With Optimized Interfacial H2O Configuration

Advanced Science, EarlyView.
A catalysis system with adjustable interfacial H2O configuration was conducted by introducing ionomer into Cu. The increasing proportion of K+‐H2O can enhance the dissociation of H2O and improve the generation ability of *H, and the increasing proportion of 4‐HB‐H2O can accelerate the transfer speed of *H to *CO intermediates with the aid of strong ...
Dawei Zhou, Songhu Bi, Jie Zhang, Jinghui Deng, Keyi Xu, Lin Xia   +5 more
wiley   +1 more source

Re-Os isotope geochemistry of komatiite-hosted Ni-Cu-PGE deposits in Finland

, 2019
We have studied the Re-Os isotope systematics of komatiite-related Ni-Cu-PGE sulfide deposits in Finland, including the Archean Ruossakero Ni-(Cu), Vaara Ni-(Cu-PGE), Tainiovaara Ni-(Cu-PGE) deposits and Ni-PGE sulfide mineralization related to a dunitic
Yang, S.-H. (S.-H.), Hanski, E. (E.), Konnunaho, J. (J.), Moilanen, M. (M.), Li, C. (C.), Zhou, L. (L.M.), Törmänen, T. (T.)   +6 more
core  

Calibração da Creatinina Sérica com Uso de Equação de Regressão: Influência na Performance da Fórmula do Estudo MDRD

Clinical and Biomedical Research, 2010
Introdução: Diferenças nos métodos de medida da creatinina sérica podem determinar amplas variações na taxa de filtração glomerular (TFG) estimada com fórmulas.
Ariana Aguiar Soares, Tatiana Falcão Eyff, Aline Bodanese Prates, Joíza Lins Camargo, Vânia Naomi Hirakata, Sandra Pinho Silveiro   +5 more
doaj