Results 151 to 160 of about 7,766,095 (306)

Modified Star Excursion Balance Test Performance in Individuals With Chronic Ankle Instability: A Participant-Level Analysis. [PDF]

J Foot Ankle Res
Forsyth L, Simpson J, Pourkazemi F, Torp DM, Burcal C, Koldenhoven RM, Donovan L, Jaffri A, Al Adal S, Mitchell A, Childs CR.   +10 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Microsaccadic modulation in goal-directed reaching. [PDF]

J Vis
Fooken J, Moraes R, Scott AM, Flanagan JR.   +3 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Bohemian Independence. [PDF]

, 1918
Reach, Emil
core   +1 more source

Online corrections to visual targets are not a distinct class of movement. [PDF]

iScience
Mekhaiel DY, Goodale MA, Corneil BD.
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Global reach [PDF]

Nature, 2005
openaire   +2 more sources

Factors Associated with Inconveniences in Daily At-home Living among Adults with Achondroplasia. [PDF]

Prog Rehabil Med
Ajimi A, Matsushita M, Kitoh H, Mishima K, Sawamura K, Imagama S.   +5 more
europepmc   +1 more source