Results 61 to 70 of about 1,729,497 (317)

Computational Modeling of the Neurofibromin-Stimulated Guanosine Triphosphate Hydrolysis by the KRas Protein

Biophysica, 2023
We report the results of computational studies of the guanosine triphosphate (GTP) hydrolysis in the active site of the KRas-NF1 protein complex, where KRas stands for the K-isoform of the Ras (ras sarcoma) protein and NF1 (neurofbromin-1) is the ...
Igor Polyakov, Alexander Nemukhin
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Catalytic Reaction Mechanism in Native and Mutant COMT from the Adaptive String Method and Mean Reaction Force Analysis.

, 2018
Catechol-O-Methyltransferase is an enzyme which catalyzes the methylation reaction of dopamine by S-Adenosylmethionine increasing the reaction rate by almost 16 orders of magnitude compared to the reaction in aqueous solution.
Iñaki, Tuñon, Kirill, Zinovjev, Esteban, Vöhringer-Martinez, David Adrian, Saez   +3 more
core   +1 more source

Regulating the interfacial charge transfer and constructing symmetry‐breaking sites for the enhanced N2 electroreduction activity

Carbon Energy, 2023
The Haber–Bosch process for industrial NH3 production is energy‐intensive with heavy CO2 emissions. Electrochemical N2 reduction reaction (NRR) is an attractive carbon‐neutral alternative for NH3 synthesis, while the challenge associated with N2 ...
Xiaoxue Zhang, Yuehan Cao, Zhen‐Feng Huang, Shishi Zhang, Chengguang Liu, Lun Pan, Chengxiang Shi, Xiangwen Zhang, Ying Zhou, Guidong Yang, Ji‐Jun Zou   +10 more
doaj   +1 more source

Effect of Equivalence Ratio on Pollutant Formation in CH₄O/H₂/NH₃ Blend Combustion

Molecules, 2023
This paper investigates the effect of equivalence ratio on pollutant formation characteristics of CH4O/H2/NH3 ternary fuel combustion and analyzes the pollutant formation mechanisms of CO, CO2, and NOX at the molecular level.
Jingyun Sun, Qianqian Liu, Mingyan Gu, Yang Wang   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Kinetic studies on the reaction of formaldehyde with amines in the presence of sulfite [PDF]

, 1999
The reaction of formaldehyde with amines with and without sulfite has been studied using anilines (RC(_6)H(_4)NH(_2)) and benzylamines (RC(_6)H(_4)CH(_2)NH(_2)). Reaction with anilines is known to produce aminomethanesulfonates, RC(_6)H(_4)NHCH(_2)SO(_3)(
Brown, Kathryn Helen
core  

Reaction mechanism of atomic layer deposition of zirconium oxide using zirconium precursors bearing amino ligands and water

Frontiers in Chemistry, 2022
As a unique nanofabrication technology, atomic layer deposition (ALD) has been widely used for the preparation of various materials in the fields of microelectronics, energy and catalysis.
Rui Xu, Zhongchao Zhou, Jing Li, Xu Zhang, Yuanyuan Zhu, Hongping Xiao, Lina Xu, Yihong Ding, Aidong Li, Guoyong Fang   +9 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Determining the Oxidation Mechanism through Radical Intermediates in Polysorbates 80 and 20 by Electron Paramagnetic Resonance Spectroscopy

Pharmaceuticals
Polysorbates 20 and 80 (PS20 and PS80) are added to many commercial biologic and vaccine pharmaceuticals. It is commonly known that these polysorbates undergo a radical oxidation mechanism; however, the identity of these radical intermediates has not ...
Adam T. Sutton, Richard R. Rustandi
doaj   +1 more source