Results 81 to 90 of about 1,729,497 (317)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Initial Reaction Mechanism of RP-3 High Temperature Oxidation Simulated with ReaxFF MD

, 2016
The high temperature oxidative mechanism of a new four-component RP-3 surrogate fuel model was investigated using the ReaxFF MD method. The evolution of the fuel molecules, oxygen, C2H4, and center dot CH3, and the underlying reactions, were obtained by ...
Han Song, Zhong Bei-Jing, Li Xiao-Xia, Guo Li, Liu Xiao-Long, Qiao Xian-Jie   +5 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

MACiE (Mechanism, Annotation and Classification in Enzymes) : novel tools for searching catalytic mechanisms

, 2007
This work is funded by the UK EPSRC and BBSRC (grant BB/C51320X/1)MACiE (Mechanism, Annotation and Classification in Enzymes) is a database of enzyme reaction mechanisms, and is publicly available as a web-based data resource.
Gemma L. Holliday, Peter Murray-rust, Torrance, James W., O'Boyle, Noel M., Thornton, Janet M., Janet M. Thornton, Almonacid, Daniel E., John B. O. Mitchell, Bartlett, Gail J., Holliday, Gemma L., Daniel E. Almonacid, Murray-Rust, Peter, Mitchell, John Blayney Owen, Gail J. Bartlett, Noel M. O’boyle, James W. Torrance   +15 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Catalytic mechanism of alpha-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling.

, 2013
Enzymatic synthesis and hydrolysis of nucleoside phosphate compounds play a key role in various biological pathways, like signal transduction, DNA synthesis and metabolism.
Bodor, A., Vértessy, Beáta G, Kele, Z., Wilmanns, Matthias, Perczel, András, Perczel, A., Vértessy, Beáta G., Rosta, Edina, Zagyva, Imre, Grolmusz, Vince I., Barabás, Orsolya, Németh, Veronika, Vertessy, B. G., Grolmusz, Vince I, Barabas, O., Grolmusz, V. I., Vértessy G., Beáta, Kele, Zoltán, Szabadka, Zoltán, Zagyva, I., Wilmanns, M., Szabadka, Z., Rosta, E., Nemeth, V., Bodor, Andrea   +24 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

AN EMPIRICAL STUDY ON THE HYDROGEN PEROXIDE REACTION WITH IODIDE IN ACID CONDITION

Alchemy, 2015
This research aimed to find out I- reaction order in the mechanism of hydrogen peroxide reaction with iodide in acid condition, to find out the form of rate law, and to show the role of H+ in reaction.
Ayuni Dita Rosalia, Patiha Patiha, Eddy Heraldy   +2 more
doaj   +1 more source