Results 111 to 120 of about 334,128 (308)
Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
TO THE ISSUE OF THE REACTIVATION OF THE TUBERCULOSIS PROCESS
Паёми Сино, 2018 Objective: The article dedicated to debating the degree of certainty of verification of certain types of reactivation of the tuberculosis process, such as relapse, reinfection and superinfection.
O.I. BOBOKHOJAEV +3 more
doaj +1 more source
RADICAL LUNG RESECTION IN TREATMENT OF PULMONARY TUBERCULOSIS
Наука и инновации в медицине, 2017 Aim - to analyze afterhistory of TB patients who had radical lung resection. Methods of research. On the basis of the results of surgical treatment of 273 patients in 2010-2011, two groups were formed: the first group - patients who were deregistered due
PV V Rogozhkin, EA A Borodulina
doaj +1 more source
Advanced Science, EarlyView.Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li +12 more
wiley +1 more source
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
Diapause development in Aquarius paludum (Heteroptera: Gerridae)
European Journal of Entomology, 2004 Diapause fixation and development were studied in females of a Czech population of Aquarius paludum by monitoring changes in oxygen uptake, weight and reproduction potential in field adults between August and February.
Tetsuo HARADA +3 more
doaj +1 more source
Advanced Science, EarlyView.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source
Frontiers in Public HealthBackgroundTuberculosis remains a global health threat, and the World Health Organization reports a limited reduction in disease incidence rates, including both new and relapse cases.
Darja Sadovska +13 more
doaj +1 more source
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Induction of Mutations in a Bacterial Virus [PDF]
, 1953 In the course of experiments designed for other purposes a paradoxical observation was made: phage λ, inactivated by UV irradiation, when adsorbed onto sensitive bacteria was reactivated when a further dose of UV was given to the phage-bacterium ...
Weigle, J. J.
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