Results 61 to 70 of about 334,128 (308)

Molecular Aspects of Varicella-Zoster Virus Latency

open access: yesViruses, 2018
Primary varicella-zoster virus (VZV) infection causes varicella (chickenpox) and the establishment of a lifelong latent infection in ganglionic neurons. VZV reactivates in about one-third of infected individuals to cause herpes zoster, often accompanied ...
Daniel P. Depledge   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Biapenem, a Carbapenem Antibiotic, Elicits Mycobacteria Specific Immune Responses and Reduces the Recurrence of Tuberculosis

open access: yesMicrobiology Spectrum, 2023
Tuberculosis (TB) still tops the list of global health burdens even after COVID-19. However, it will sooner transcend the current pandemic due to the prevailing risk of reactivation of latent TB in immunocompromised individuals. The indiscriminate misuse
Isha Pahuja   +8 more
doaj   +1 more source

Modulation of the asymmetry of sea urchin sperm flagellar bending by calmodulin [PDF]

open access: yes, 1985
Sea urchin spermatozoa demembranated with Triton X-100 in the presence of EGTA, termed potentially asymmetric, generate asymmetric bending waves in reactivation solutions containing EGTA. After they are converted to the potentially symmetric condition by
Brokaw, C. J., Nagayama, S. M.
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Clinical and epidemiological features of infections caused by HHV-6A and HHV-6B [PDF]

open access: yesКлиническая микробиология и антимикробная химиотерапия, 2018
Objective. To determine the detection rates of HHV-6A and HHV-6B compared to other herpes viruses in children of different age groups. Materials and Methods.
Lysenkova M.Yu.   +10 more
doaj  

serologic markers of Epstein-Barr virus reactivation in the conditions of viral encephalitis in young patients

open access: yesЖурнал инфектологии, 2015
The reactivation of Epstein-Barr virus on the background of some basic disease revealed during the development of encephalitis of various etiology could act as a co-factor to trigger the process of demyelinazation of central nervous system tissues ...
O. V. Goleva   +2 more
doaj   +1 more source

Competition and forgetting during context-based episodic memory retrieval [PDF]

open access: yes, 2016
Recent memory models highlight the importance of contextual information for remembering episodic events. A consequence of binding event memories with their context is that contextually related memories can interfere with the retrieval of targeted ...
Dutcher, Anthony   +3 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Crustal fault reactivation facilitating lithospheric folding/buckling in the central Indian Ocean

open access: yes, 1996
High-quality, normal-incidence seismic reflection data confirm that tectonic deformation in the central Indian Ocean occurs at two spatial scales: whole lithosphere folding with wavelengths varying between 100 and 300 km, and compressional reactivation ...
Beekman, F.   +3 more
core   +1 more source

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