Results 61 to 70 of about 338,740 (309)

Asteroid Diameters and Albedos from NEOWISE Reactivation Mission Years 4 and 5 [PDF]

, 2020
The Near-Earth Object Wide-field Infrared Survey Explorer (NEOWISE) spacecraft has been conducting a two-band thermal infrared survey to detect and characterize asteroids and comets since its reactivation in 2013 December.
Bauer, J. M., Cutri, R. M., Grav, T., Kramer, E., Mainzer, A. K., Masiero, Joseph R., Pittichová, J., Sonnett, S., Wright, E. L.   +8 more
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Crustal fault reactivation facilitating lithospheric folding/buckling in the central Indian Ocean

, 1996
High-quality, normal-incidence seismic reflection data confirm that tectonic deformation in the central Indian Ocean occurs at two spatial scales: whole lithosphere folding with wavelengths varying between 100 and 300 km, and compressional reactivation ...
Beekman, F., Bull, Jonathan M., Cloetingh, S., Scrutton, R.A.   +3 more
core   +1 more source

Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain

Memorias do Instituto Oswaldo Cruz, 1998
In the past few years, new aspects of the immunopathology of Chagas' disease have been described in immunosuppressed patients, such as fatal central nervous system lesions related to the reactivation of the parasite. This article is the first description
Pacheco Raquel S, Ferreira Marcelo S, Machado Maria Inês, Brito Célia MM, Pires Marize Q, Da-Cruz Alda M, Coutinho Sérgio G   +6 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals. [PDF]

, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Bale, Michael J, Busch, Michael P, Cox, Bryan, Deeks, Steven G, Hoh, Rebecca, Kearney, Mary F, Kulpa, Deanna A, Lackman-Smith, Carol, Maldarelli, Frank, Ptak, Roger G, Stone, Mars, Subramanian, Krupa, Wiegand, Ann, Wonderlich, Elizabeth R   +13 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Tectonic history of the South Tannuol Fault Zone (Tuva region of the northern Central Asian Orogenic Belt, Russia) : constraints from multi-method geochronology [PDF]

, 2020
In this study, we present zircon U/Pb, plagioclase and K-feldspar Ar-40/Ar-39 and apatite fission track (AFT) data along the South Tannuol Fault Zone (STFZ).
De Grave, Johan, Mikhailova, Polina, Nachtergaele, Simon, Van Ranst, Gerben, Vetrov, Evgeny, Vetrova, Natalia, Zhimulev, Fedor   +6 more
core   +1 more source

The Management Problems of Patient with Chronic Hepatitis B Infection and Its Reactivation

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020
Hepatitis B virus infection is a major global health problem in the world  and particularly in Indonesia.    It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer.
Tri Asih Imro'ati, Ummi Maimunah
doaj   +1 more source