Results 61 to 70 of about 203,884 (312)

Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients [PDF]

, 2014
AIM: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with lymphoma. METHODS: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during ...
Su, W.P.; Wen, C.C.; Hsiung, C.A.; Su, I.J.; Cheng, A.L.; Chang, M.C.; Tsao, C.J.; Kao, W.Y.; Uen, W.C.; Hsu, C.; Hsu, C.H.; Lu, Y.S.; Tien, H.F; Chao, T.Y.; Chen L.T.; Jacqueline Whang-Peng; Chen, P.J.
core   +1 more source

Clinical and epidemiological features of infections caused by HHV-6A and HHV-6B [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2018
Objective. To determine the detection rates of HHV-6A and HHV-6B compared to other herpes viruses in children of different age groups. Materials and Methods.
Lysenkova M.Yu., Karazhas N.V., Rybalkina T.N., Veselovsky P.A., Burmistrov E.M., Boshyan R.E., Melekhina E.V., Svitich O.A., Muzyka A.D., Petukhova E.V., Gorelov A.V.   +10 more
doaj  

serologic markers of Epstein-Barr virus reactivation in the conditions of viral encephalitis in young patients

Журнал инфектологии, 2015
The reactivation of Epstein-Barr virus on the background of some basic disease revealed during the development of encephalitis of various etiology could act as a co-factor to trigger the process of demyelinazation of central nervous system tissues ...
O. V. Goleva, E. A. Murina, Z. A. Osipova   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Host Cell Reactivation and Transcriptional Activation of Carboplatin-Modified BRCA1 [PDF]

, 2014
The breast cancer susceptibility gene 1 ( BRCA1 ) has been shown to maintain genomic stability through multiple functions in the regulation of DNA damage repair and transcription.
Adisorn Ratanaphan, Bhutorn Canyuk
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection [PDF]

, 2011
As obligate intracellular parasites, viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two
McMahon, Robert
core  

A Case of Hepatitis B Reactivation with Acute Flare Three Months After Tenofovir Prophylaxis Withdrawal in a Allogenic Hematopoietic Stem Cell Transplantation Patient [PDF]

, 2018
Hepatitis B virus (HBV) infection is a major health problem worldwide. HBV reactivation is associated with high mortality rates in hematopoietic stem cell transplantation (HSCT) and, prophylactic antiviral treatment is suggested to prevent this ...
Aslan, Ferhat Gürkan, Bilal TOKA, Ferhat Gürkan ASLAN, Ahmet Tarık EMİNLER, Aydın Şeref KÖKSAL, Toka, Bilal, Altındiş, Mustafa, Eminler, Ahmet Tarık, Köksal, Aydın Şeref, Mustafa ALTINDİŞ   +9 more
core   +1 more source

Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain

Memorias do Instituto Oswaldo Cruz, 1998
In the past few years, new aspects of the immunopathology of Chagas' disease have been described in immunosuppressed patients, such as fatal central nervous system lesions related to the reactivation of the parasite. This article is the first description
Pacheco Raquel S, Ferreira Marcelo S, Machado Maria Inês, Brito Célia MM, Pires Marize Q, Da-Cruz Alda M, Coutinho Sérgio G   +6 more
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source