Results 61 to 70 of about 352,512 (360)

Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome

Viruses, 2020
Human immunodeficiency virus type-1 (HIV-1) can either undergo a lytic pathway to cause productive systemic infections or enter a latent state in which the integrated provirus remains transcriptionally silent for decades. The ability to latently infect T-
Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Mudit Tyagi   +2 more
doaj   +1 more source

Real-World Effectiveness of Antiviral Prophylaxis for Preventing Hepatitis B Virus (HBV) Reactivation in Patients Undergoing Immunosuppressive Therapy

Viruses
This study evaluated the characteristics of patients receiving prophylactic antiviral therapy against hepatitis B virus (HBV) infection due to immunosuppressive treatment and assessed the occurrence of HBV reactivation.
İnci Yılmaz Nakir, Bilge Çağlar, Esra Zerdali, Rumeysa Gülistan Karaduman, Filiz Pehlivanoğlu   +4 more
doaj   +1 more source

Hepatitis B virus reactivation in cancer patients with positive Hepatitis B surface antigen undergoing PD-1 inhibition

Journal of Immunotherapy for Cancer, 2019
BackgroundHepatitis B virus (HBV) reactivation is a serious complication in patients with cancers and HBV infection undergoing immunosuppressant treatment or chemotherapy. However, the safety of anti-programmed cell death (PD) -1 and anti-programmed cell
Xuan-Ye Zhang, Yi-Xin Zhou, Chen Chen, W. Fang, Xiuyu Cai, Xiaoshi Zhang, Ming-bo Zhao, Bei Zhang, Wenqi Jiang, Zuan Lin, Yu-Xiang Ma, Yun-Peng Yang, Yan Huang, Hong-Yun Zhao, Rui-Hua Xu, Shao-Dong Hong, Li Zhang   +16 more
semanticscholar   +1 more source

Changes in serologic markers of hepatitis B in autologous hematopoietic stem cell transplantation recipients

Journal of Applied Hematology, 2016
Introduction: Hepatitis B virus (HBV) infection is one of the most prominent health threats worldwide. Hepatitis B exacerbation is a significant cause of morbidity and mortality in patients who are the candidates of cytotoxic, immunosuppressive therapy ...
Mehmet Hilmi Dogu, Sibel Hacioglu, Ismail Sari, Ali Keskin   +3 more
doaj   +1 more source

Profiling the Blood Compartment of Hematopoietic Stem Cell Transplant Patients During Human Cytomegalovirus Reactivation

Frontiers in Cellular and Infection Microbiology, 2021
Human cytomegalovirus (HCMV) is a widespread pathogen establishing a latent infection in its host. HCMV reactivation is a major health burden in immunocompromised individuals, and is a major cause of morbidity and mortality following hematopoietic stem ...
Biana Bernshtein, Aharon Nachshon, Miri Shnayder, Lauren Stern, Selmir Avdic, Emily Blyth, Emily Blyth, Emily Blyth, Emily Blyth, David Gottlieb, David Gottlieb, David Gottlieb, Allison Abendroth, Barry Slobedman, Noam Stern-Ginossar, Michal Schwartz   +15 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Molecular Aspects of Varicella-Zoster Virus Latency

Viruses, 2018
Primary varicella-zoster virus (VZV) infection causes varicella (chickenpox) and the establishment of a lifelong latent infection in ganglionic neurons. VZV reactivates in about one-third of infected individuals to cause herpes zoster, often accompanied ...
Daniel P. Depledge, Tomohiko Sadaoka, Werner J. D. Ouwendijk   +2 more
doaj   +1 more source

Biapenem, a Carbapenem Antibiotic, Elicits Mycobacteria Specific Immune Responses and Reduces the Recurrence of Tuberculosis

Microbiology Spectrum, 2023
Tuberculosis (TB) still tops the list of global health burdens even after COVID-19. However, it will sooner transcend the current pandemic due to the prevailing risk of reactivation of latent TB in immunocompromised individuals. The indiscriminate misuse
Isha Pahuja, Akanksha Verma, Antara Ghoshal, Suparba Mukhopadhyay, Anjna Kumari, Aishwarya Shaji, Shivam Chaturvedi, Ved Prakash Dwivedi, Ashima Bhaskar   +8 more
doaj   +1 more source

Sleep spindle refractoriness segregates periods of memory reactivation

, 2018
The stability of long-term memories is enhanced by reactivation during sleep. Correlative evidence has linked memory reactivation with thalamocortical sleep spindles, although their functional role is not fully understood.
Wang, Margaret, Norman, Kenneth A., Brooks, Paula P., Paller, Ken A., Paula Pacheco, Antony, James W., Kenneth A. Norman, Piloto, Luis, Pacheco, Paula, James W. Antony, Ken A. Paller, Luis Piloto, Margaret Wang   +12 more
core   +1 more source