Results 121 to 130 of about 1,698 (291)

Heat-Induced Reactivation of HSV-1 in Latent Mice: Upregulation in the TG of CD83 and Other Immune Response Genes and Their LAT-ICP0 Locus

, 2009
PURPOSE. To determine changes in host gene expression in HSV-1 latent trigeminal ganglia (TG) after hyperthermic stress. METHODS. Scarified corneas of 6-week-old female BALB/c mice were inoculated with either HSV-1 17Syn+ (high phenotypic reactivator) or
Clement, C., Kaufman, H. E., Hill, J. M., Bhattacharjee, Partha S.   +3 more
core   +1 more source

Recent Advances in Carbon Cathode Materials toward High‐Performing Zinc‐Ion Hybrid Supercapacitors

Advanced Science, EarlyView.
Aqueous zinc‐ion hybrid supercapacitors (ZHSCs) have emerged as promising next‐generation electrochemical energy‐storage devices. Porous carbon materials have been extensively studied as cathodes, with advances in tailoring pore structures and material properties to enhance performance.
Take Hirooka, Zhaolin Liu, Ivan P. Parkin, Guanjie He   +3 more
wiley   +1 more source

Synthesis and comparison of activity of potential reactivators of acetylcholinesterase inhibited by cyclosarine

, 2009
SYNTHESIS OF POTENCIAL QUATERNARY ACETYLCHOLINESTERASE REACTIVATORS AND EVALUATION OF THEIR POTENCY TO REACTIVATE CYCLOSARIN-INHIBITED AChE Mgr. Lukáš Lipka Department of pharmaceutical chemistry and drug control, Charles University in Prague, Faculty of
Lipka, Lukáš
core  

Effectiveness of L-arginine or nitric oxide as a reactivator and an antidote against cholinesterase pesticides and other toxic substances [PDF]

, 2018
The cholinergic system is one of the most important neuromediator systems in organisms that manage physiological functions, biology, behavior, adaptation, intellect.
T. Dencheva, Elitsa, I. Ivanov, Radoy
core  

Wake‐Up and Fatigue under Electrical Cycling in HfO2‐Based Ferroelectrics: Mechanisms and Strategies toward Reliable Devices

Advanced Science, EarlyView.
HfO2‐based ferroelectrics exhibit wake‐up and fatigue behaviors during electrical cycling, significantly affecting device endurance and reliability. These phenomena are governed by defect dynamics, including oxygen vacancy redistribution and charge trapping.
Hongseok Kim, Shinhyeong Lee, Hyojun Choi, Minseung Park, Hyunah Cho, Min Hyuk Park, Yunseok Kim   +6 more
wiley   +1 more source

Illuminating the Unseen: Dynamic Butyrylcholinesterase Detection Driving Precision Medicine and Environmental Toxicology

SmartMat
Butyrylcholinesterase (BChE), an essential serine hydrolase playing critical functions in both neurobiological processes and toxicological responses, has gained recognition as a crucial biomarker for detecting hepatic impairment, Alzheimer's disease (AD),
Min Liu, Shuaige Bai, Shuai Huang, Ting Luo, Yiyang Zhou, Meihui Liu, Xueping Feng, Wenbin Zeng   +7 more
doaj   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source