Results 181 to 190 of about 26,803 (327)

Novel p53 reactivators that are synergistic with olaparib for the treatment of gynecologic cancers with mutant p53. [PDF]

Transl Oncol
Smith LE, Padilla JL, Licor A, Steinkamp MP, Lagutina IV, Guo Y, Devor EJ, Pankratz VS, Sallmyr A, Oyebamiji OM, Choe JY, Williams GL, Leslie KK.   +12 more
europepmc   +1 more source

Studies on the rare of central catecholaminergic mechanisms in the antidotal effect of the oxime HI 6 in soman poisoned mice [PDF]

, 1988
Arbogast, Helmut, Hallek, M., Reithmann, C., Szinicz, L.   +3 more
core  

Evaluation of methods to reactivate preserved ruminal inoculum, assessed through in vitro fermentation kinetics and forage digestibility

, 2019
Maria Guadalupe Domínguez-Ordóñez, Luis Aalberto Miranda-Romero, Pedro Martı́nez-Hernández, Maximino Huerta-Bravo, Ezequias Castillo‐Lopez   +4 more
openalex   +2 more sources

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator. [PDF]

Cancer Discov
Puzio-Kuter AM, Xu L, McBrayer MK, Dominique R, Li HH, Fahr BJ, Brown AM, Wiebesiek AE, Russo BM, Mulligan CL, Yang H, Battaglia J, Robell KA, Thomas DH, Huang KS, Solovyov A, Greenbaum BD, Oliner JD, Davis TW, Dumble ML, Johnson ML, Xiong S, Yang P, Lozano G, Fellous MM, Vu BT, Schram AM, Levine AJ, Poyurovsky MV.   +28 more
europepmc   +1 more source

Reactivation of the PI3K/mTOR Signaling Pathway Confers Resistance to the FGFR4 Inhibitor FGF401 [PDF]

Hung Huynh, Wai Har Ng
openalex   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

PYNNACLE phase II clinical trial protocol: rezatapopt (PC14586) monotherapy in advanced or metastatic solid tumors with a <i>TP53</i> Y220C mutation. [PDF]

Future Oncol
Schram AM, Fellous M, LeDuke K, Schmid A, Dumbrava EE.   +4 more
europepmc   +1 more source

Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy

Advanced Science, EarlyView.
A multifunctional nano immunostimulant is first proposed for efficient tumor immunotherapy. The ER targeted ability, superior ROS production, efficient GSH consumption, coupled with the HIF suppression, jointly arouses ICD/ferroptosis pathways to realize efficient tumor immunotherapy.
Guanhong Guo, Wenda Zhong, Huishuang Zhao, Yueying An, Xinyu Dong, Zhengbo Li, Shuangfeng Qin, Guangzhao Xu, Xiangguo Yue, Xudong Wang, Wen Sun, Zhe‐Sheng Chen, Weiguo Song, Liuya Wei, Fahui Li   +14 more
wiley   +1 more source

Divergence of DNA tumor mutations in cerebrospinal fluid in metastatic breast cancer patients with leptomeningeal metastases. [PDF]

Breast
Wessels PH, Cornellisen S, Monkhorst K, Sonke GS, Broeks A, Linders D, van den Broek D, Boelens MC, Brandsma D.   +8 more
europepmc   +1 more source