Results 161 to 170 of about 124,194 (317)

Self‐Assisted Charge Storage‐Release Mechanism Enabling Flexible Design of Biomimetic Triboelectric Nanogenerators

Advanced Science, EarlyView.
Inspired by the mimosa, this study develops a flexible triboelectric nanogenerator with a novel microneedle array and battery‐mimetic architecture. The device introduces a spontaneous charge self‐regulation mechanism that confines the electric field below the air breakdown threshold, and achieves an outstanding charge density of 396.50 µC m−2 ...
Hanpeng Gao, Yamin Hu, Li Li, Ana Sofia Oliveira Henriques Moita, Xi Wang, Zong Meng, Zhiwu Han, Yan Liu   +7 more
wiley   +1 more source

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators. [PDF]

Cancer Discov
Fece de la Cruz F, Varkaris A, Patel PS, Kushner EW, Morales-Giron AA, Lee SS, Singh A, Kim CT, Norden BL, Ehnstrom S, Riedl JM, Curtis JM, Barnes H, Kehlmann AM, Chevalier NJ, Okuma HS, Patel M, Wirth LJ, Connell B, Nugent F, Pappas L, Lau K, Juric D, Hopkins JL, Guiley KZ, Shokat KM, Gulhan DC, Parikh AR, Corcoran RB.   +28 more
europepmc   +1 more source

Oxime@Zirconium-Metal-Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning. [PDF]

Inorg Chem, 2023
González L, Martín-Romera JD, Sánchez-Sánchez P, Navarro JAR, Barea E, Maldonado CR, Carmona FJ.   +6 more
europepmc   +1 more source

The epithelial danger signal IL-1α is a potent activator of fibroblasts and reactivator of intestinal inflammation.

American Journal of Pathology, 2015
M. Scarpa, S. Kessler, T. Sadler, G. West, C. Homer, C. McDonald, C. A. de la Motte, C. Fiocchi, E. Stylianou   +8 more
semanticscholar   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Novel p53 reactivators that are synergistic with olaparib for the treatment of gynecologic cancers with mutant p53. [PDF]

Transl Oncol
Smith LE, Padilla JL, Licor A, Steinkamp MP, Lagutina IV, Guo Y, Devor EJ, Pankratz VS, Sallmyr A, Oyebamiji OM, Choe JY, Williams GL, Leslie KK.   +12 more
europepmc   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Progress in Antidotes (Acetylcholinesterase Reactivators) Against Organophosphorus Pesticides [PDF]

, 2011
Anna Horova, Daniel Jun, Jana Zdarova-Karasova, Kamil Kuca, Kamil Musilek, Miroslav Pohanka, Ondrej Holas   +6 more
core   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

PYNNACLE phase II clinical trial protocol: rezatapopt (PC14586) monotherapy in advanced or metastatic solid tumors with a <i>TP53</i> Y220C mutation. [PDF]

Future Oncol
Schram AM, Fellous M, LeDuke K, Schmid A, Dumbrava EE.   +4 more
europepmc   +1 more source