Results 151 to 160 of about 124,194 (317)

Cryoablation Activates the cGAS–STING‐CXCL10 Axis in Macrophages to Enhance Anti‐Tumor Immunity in NSCLC

Advanced Science, EarlyView.
Tumor dsDNA released by cryoablation is taken up by macrophages, activating the cGAS‐STING signaling pathway. This leads to an expansion of the CXCL10+ macrophage pool and increased secretion of CXCL10, which in turn recruits CXCR3+ T cells from draining lymph nodes into the tumor microenvironment to exert anti‐tumor effects.
Xinxin Zhi, Zhengcao Xing, Libo Luo, Jiale Wang, Xinyu Liu, Jia Yu, Jizhong Yin, Bin Chen, Yiwei Liu, Hui Sun, Guanghui Gao, Lei Wang, Xiaoxia Chen, Fei Li, Hu Ma, Lin Wang, Shuo Yang, Shengxiang Ren   +17 more
wiley   +1 more source

The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs.

Chemico-Biological Interactions, 2017
M. Malfatti, Heather A. Enright, Nicholas A. Be, E. Kuhn, Saphon, Hok, M. W. McNerney, Victoria Lao, Tuan H. Nguyen, F. Lightstone, T. Carpenter, B. Bennion, C. A. Valdez   +12 more
semanticscholar   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Imidazole as a Pendant Reactivation Ligand Increases Efficacy Scope for Reactivation and Resurrection of Organophosphorus-Inhibited/Aged Cholinesterases by Quinone Methide Precursors. [PDF]

ACS Chem Neurosci
Lovins AR, Miller KA, Homoelle RK, Hoover HJ, McElroy CA, Callam CS, Hadad CM.   +6 more
europepmc   +1 more source

AI‐Assisted Self‐Powered Wearable Dual‐Mode Sensor With TENG and Stretchable Optical Fiber for Neurological Disorder Diagnostics

Advanced Science, EarlyView.
This manuscript presents the WDMS platform, an AI‐assisted, self‐powered wearable dual‐mode sensor for tele‐neurology. It integrates a contact–separation TENG insole with stretchable polyurethane optical‐fiber strain sensors to synchronously track plantar pressure and lower‐limb muscle deformation.
Tianliang Li, Han Liu, Guoxu Liu, Qian'ao Wang, Haotian Zhou, Guiyi Liu, Yan Xu, Jun Wang, Zuqiang Wang, Feng Zhu, Feiling Luo, Zhong Lin Wang, Chi Zhang   +12 more
wiley   +1 more source

HIV-1 latency reversal agent boosting is not limited by opioid use

JCI Insight
Opioid use may affect the HIV-1 reservoir and its reversal from latency. We studied 47 virally suppressed people with HIV (PWH) and observed that lower concentration of HIV-1 latency reversal agents (LRAs), used with small molecules that did not reverse ...
Tyler Lilie, Jennifer Bouzy, Archana Asundi, Jessica Taylor, Samantha Roche, Alex Olson, Kendyll Coxen, Heather Corry, Hannah Jordan, Kiera Clayton, Nina Lin, Athe Tsibris   +11 more
doaj   +1 more source

Reactive syringofibroadenoma

Indian Journal of Dermatology, Venereology and Leprology, 2020
Piyush, Kumar, Anupam, Das, P C, Das
openaire   +2 more sources

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. [PDF]

Chem Res Toxicol, 2023
Váňová N, Múčková L, Kalíšková T, Lochman L, Bzonek P, Švec F.   +5 more
europepmc   +1 more source

Studies on the rare of central catecholaminergic mechanisms in the antidotal effect of the oxime HI 6 in soman poisoned mice [PDF]

, 1988
Arbogast, Helmut, Hallek, M., Reithmann, C., Szinicz, L.   +3 more
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