Results 211 to 220 of about 26,803 (327)

TP53 Mutation-Specific Dysregulation of Store-Operated Calcium Entry and Apoptotic Sensitivity in Triple-Negative Breast Cancer. [PDF]

Cancers (Basel)
Rabab KE, Buchanan PJ, Colley G, White A, Murphy A, McCormack C, Eustace AJ.   +6 more
europepmc   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides. [PDF]

J Enzyme Inhib Med Chem, 2022
Kohoutova Z, Malinak D, Andrys R, Svobodova J, Psotka M, Schmidt M, Prchal L, Musilek K.   +7 more
europepmc   +1 more source

Recent research in neurotoxicology [PDF]

, 2011
Thriel, C. van
core  

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Advanced Science, EarlyView.
A hyaluronic acid methacrylate (HAMA) hydrogel incorporating DNA tetrahedrons loaded with Asiatic acid (TDN@AA) was developed. HM‐TDN@AA promotes angiogenesis of endothelial cells (ECs), inhibits osteoclastogenesis from bone marrow–derived macrophages (BMDMs), and enhances osteogenesis of mesenchymal stem cells (MSCs) via STAT3‐mediated mitochondrial ...
Yiwen Huang, Yiming Zhang, Yisheng Feng, Qixiang Yang, Beiyuan Gao, Haiyang Xu, Cheng Huang, Kaili Lin, Yuanzhi Xu, Peiqi Zhu   +9 more
wiley   +1 more source

Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53. [PDF]

Front Pharmacol
Taritsa IC, Fossel ET.
europepmc   +1 more source

Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice. [PDF]

Molecules, 2022
Wei Z, Zhang X, Nie H, Yao L, Liu Y, Zheng Z, Ouyang Q.   +6 more
europepmc   +1 more source

Promoting vocabulary learning during sleep at home using closed‐loop targeted memory reactivation [PDF]

Federico Salfi, Aurora D’Atri, Benedetto Arnone, Domenico Corigliano, Giulia Amicucci, Lorenzo Viselli, Federica Naccarato, Fabiana Festucci, Daniela Tempesta, Michèle Ferrara   +9 more
openalex   +1 more source

Prospective long‐term study of hepatitis B virus reactivation in patients with hematologic malignancy [PDF]

, 2014
Akihiro Tamori, Masayuki Hino, Etsushi Kawamura, Hideki Fujii, Sawako Uchida‐Kobayashi, Hiroyasu Morikawa, Hirohisa Nakamae, Masaru Enomoto, Yoshiki Murakami, Norifumi Kawada   +9 more
openalex   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source