Results 221 to 230 of about 1,698 (291)

Clinical outcomes of venetoclax combined with hypomethylating agents <i>versus</i> hypomethylating agents alone in <i>TP53</i>-mutated myelodysplastic syndromes. [PDF]

Haematologica
Aldapt M, Wang YH, Shah KJ, El Kettani M, Foran J, Kharfan-Dabaja M, Murthy H, Al-Kali A, Shah MV, Alkhateeb H, Saliba AN, Hogan W, Yi CA, Sproat L, Punwani N, Khera N, Palmer J, Litzow M, Tefferi A, Gangat N, Patnaik MM, Badar T.   +21 more
europepmc   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

The Novel Viral Non‐Coding RNA LMP2A‐IT1 Promotes the Lytic Replication of EBV

Advanced Science, EarlyView.
Decades after its discovery, EBV's genome still harbours unannotated “dark matter”. LMP2A‐IT1, a novel EBV‐encoded transcript identified in this work, is strongly upregulated during lytic replication and promotes BZLF1 expression, likely through activation of inflammatory responses, thereby enhancing viral propagation in a self‐reinforcing positive ...
Zheng‐Zhou Lu, Jun‐Fei Wu, Nannan Zhu, Ming‐Hui Yang, Le‐Le Zhang, Yuan‐Tao Liu, Wei‐Jun Chen, Jin‐Kun Tang, Jia‐Wei Ge, Chao‐Bo Lei, Tao Zhang, Yu Wang, Chao‐Yun Huang, Qian Zhong, Mu‐Sheng Zeng, Yan Li   +15 more
wiley   +1 more source

Transplant options and outcomes for TP53 myeloid disease. [PDF]

Hematology Am Soc Hematol Educ Program
Fernández HF, Mishra A.
europepmc   +1 more source

NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF‐κB Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated cachexia (CAC) is a devastating multifactorial syndrome characterized by progressive skeletal muscle atrophy. Its mechanisms remain incompletely clarified, with limited effective therapeutic targets. NUB1, a negative regulator of ubiquitin‐like proteins mediating protein degradation, has not been fully elucidated in CAC ...
Yuqi Han, Yaru Xia, Weiquan Li, Jiaming Wu, Tiexi Yu, Diaoyi Tan, Daojia Miao, Wen Li, Xuejiao Dong, Jiemin Li, Yu Jiao, Guixiao Huang, Xiaoping Zhang, Hongmei Yang   +13 more
wiley   +1 more source

Dynamic Supercooled Crystal–Gels for Ultrafast, Reversible Mechanical Adaptative Materials

Advanced Science, EarlyView.
A dynamic supercooled crystal–gel mimics starfish tissue by storing non‐equilibrium energy in a metastable liquid. A gentle touch triggers templated crystallization, producing a 2596‐fold stiffness increase with negligible volume change. The lattice disintegrates reversibly under humidity or warmth.
Yuesong Lv, Hao Feng, Zhangqin Yang, Jianping Yin, Hanfei Li, Bo Zhou, Yuyang Meng, Yuntong Su, Xinxing Zhang, Xibo Pei   +9 more
wiley   +1 more source

Nanodiamond mediated delivery of pyridinium oxime antidotes to central nervous system for potential treatment of exposure to nerve agents. [PDF]

Chem Biol Interact
Bondar D, Smirnova O, Nagappa NM, Heinmaa I, Soukup O, Kobrlova T, Opravil J, Hrabinova M, Jun D, Starkov P, Spuul P, Kuča K, Mochalin VN, Karpichev Y.   +13 more
europepmc   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

Structure-guided modification of a lead cholinesterase-targeting oxime to improve peripheral site binding. [PDF]

Arh Hig Rada Toksikol
Maraković N, Probst N, Čadež T, Zandona A.   +3 more
europepmc   +1 more source

Living Electronics: Microbial Metabolism as Batteries, Resistors, and Capacitors

Advanced Electronic Materials, EarlyView.
Three microorganisms are assigned the three elementary roles of a circuit on one sheet of paper. Dormant Bacillus subtilis spores germinate to switch the power source on; a photosynthetic Synechocystis biofilm sets resistance by the color and intensity of light; and a respiring Shewanella oneidensis biofilm stores charge. Together they form a printable
Botian Wang, Ruohan Zhang, Seokheun Choi
wiley   +1 more source